Influence of the Pre-shock State on the Prognosis of Medical Patients with Sepsis: A Retrospective Cohort Study.
- Author:
Lei ZHANG
1
;
Xiao Yan GAI
2
;
Xin LI
2
;
Ying LIANG
2
;
Meng WANG
2
;
Fei Fan ZHAO
2
;
Qing Tao ZHOU
2
;
Yong Chang SUN
2
Author Information
- Publication Type:Journal Article
- Keywords: Critical care; Mortality; Pre-shock state; Sepsis; Septic shock
- MeSH: Humans; Shock, Septic; Retrospective Studies; Sepsis; Hospitalization; Universities
- From: Biomedical and Environmental Sciences 2023;36(12):1152-1161
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the effects of the pre-shock state on the mortality of patients with sepsis.
METHODS:We enrolled patients with sepsis admitted to the medical intensive care unit of a tertiary care university hospital. These patients were then classified into three groups: sepsis, pre-shock state, and septic shock. The primary outcome was the 28-day mortality rate. The secondary outcomes were the 90-day, 180-day, and 1-year mortality rates.
RESULTS:A total of 303 patients (groups: sepsis 135 [44.6%]), pre-shock state (93 [30.7%]), and septic shock (75 [24.8%]) completed the 1-year follow-up. The mortality rates at 28 days, 90 days, and 180 days and 1 year were significantly higher in the pre-shock state group than those of the sepsis group, but significantly lower than those in the septic shock group, especially among older patients. When compared with the pre-shock state group, the sepsis group had significantly lower mortality risks at 28 days, 90 days, and 180 days and 1 year, whereas the sepsis shock group had higher mortality risks at these time points.
CONCLUSION:The mortality rates of patients in the pre-shock state were notably different from those of patients with sepsis or septic shock. The introduction of a modified sepsis severity classification, which includes sepsis, pre-shock state, and septic shock, could offer valuable additional prognostic information.
