Role of mitophagy in the development and progression of liver-related diseases
- VernacularTitle:线粒体自噬在肝脏相关疾病发生发展中的作用
- Author:
Meng PAN
1
;
Xiaoyan SHI
1
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Mitophagy; Pathologic Processes
- From: Journal of Clinical Hepatology 2024;40(2):413-418
- CountryChina
- Language:Chinese
- Abstract: Mitophagy is a type of selective autophagy during which cells specifically remove damaged mitochondria in response to nutrient deficiency or external stimulation and thus maintain the integrity of mitochondrial function and cellular homeostasis. In recent years， a large number of studies have shown that dysfunction of mitophagy is closely associated with the development and progression of various liver-related diseases such as nonalcoholic fatty liver disease， drug-related liver injury， viral hepatitis， and hepatocellular carcinoma. This article summarizes the specific mechanisms of mitophagy in regulating liver-related diseases and further elaborates on the potential therapeutic targets of mitophagy in liver-related diseases， in order to provide more effective therapeutic strategies for the clinical treatment of liver diseases.
