Current research status of animal models for acute-on-chronic liver failure
- VernacularTitle:慢加急性肝衰竭动物模型研究现状
- Author:
Wei LIU
1
;
Lang BAI
1
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; Acute-On-Chronic Liver Failure; Models， Animal
- From: Journal of Clinical Hepatology 2024;40(1):187-192
- CountryChina
- Language:Chinese
- Abstract: Acute-on-chronic liver failure has complex conditions， rapid progression， and a high mortality rate， and further studies are still needed to clarify its pathogenesis and etiology. The establishment of animal models for acute-on-chronic liver failure can not only provide a good basis for exploring the pathogenesis of acute-on-chronic liver failure， but also provide an experimental basis for clinical treatment. Through a literature review， this article summarizes the methods commonly used to establish the animal models of acute-on-chronic liver failure， including carbon tetrachloride combined with LPS/GaIN， thioacetamide combined with LPS， serum albumin， and bile duct ligation. This article analyzes the characteristics of various animal models， so as to provide documentary and experimental bases for further exploration of more ideal animal models.
