Effects of extracorporeal shock wave lithotripsy on PCT, renal function and inflammatory index levels in patients with indinavir-related urinary calculi
- VernacularTitle:体外冲击波碎石对茚地那韦相关泌尿结石患者PCT、肾功能及炎性指标水平的影响
- Author:
Ya GAO
1
;
Nannan LI
1
Author Information
- Publication Type:Journal Article
- Keywords: in vitro shock wave lithotripsy; indenavir; urinary calculi; calcitonogenen; C reaction protein
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(3):437-441
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To investigate the effects of extracorporeal shock wave lithotripsy (ESWL) on procalcitonin (PCT), renal function and inflammatory index levels in patients with indinavir-induced urinary calculi so as to provide reference for clinical practice. 【Methods】 A total of 77 patients with urinary calculi admitted to the Department of Urology of our hospital from January 2017 to January 2021 were selected for retrospective analysis. They were divided into control group (38 cases, non-indinavir related urinary calculi) and observation group (39 cases, indinavir-related urinary calculi) according to the years of the disease. Before treatment and 7 days after treatment, the serum levels of PCT, CRP, Scr, UA, Kim1, VAS scores, and IgG, IgM, MDA, and SOD levels were compared between the two groups. 【Results】 The expressions of serum PCT and CRP at 7 days after treatment in the two groups were significantly lower than those before treatment, and the improvement degree of the observation group was significantly higher than that in the control group (P<0.05). The renal function indexes of urine Kim-1, Scr and BUA in the control group after treatment were significantly better than those in the observation group (P<0.05). However, there was no significant difference in VAS score between the two groups before and after treatment (P>0.05), but the intraoperative blood loss and MAP 20 min after induction of anesthesia were significantly better than those in the control group. Seven days after treatment, GSH-Px and SOD were significantly better in the observation group than in the control group and before treatment (P<0.05). 【Conclusion】 ESWL treatment for patients with indinavir-induced urinary calculi can effectively reduce the expressions of serum PCT and CRP, improve renal function indexes, reduce intraoperative blood loss, and reduce the level of inflammatory indexes; the clinical effect is good.
