Advances in Salmonella-mediated targeted tumor therapy
10.16438/j.0513-4870.2023-0700
- VernacularTitle:沙门氏菌介导的肿瘤靶向治疗研究进展
- Author:
Zhao-rui LÜ
1
;
Dong-yi LI
1
;
Yu-yang ZHU
1
;
He-qi HUANG
1
;
Hao-nan LI
1
;
Zi-chun HUA
2
Author Information
1. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China
2. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China; School of Life Sciences, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing 210023, China; Nanjing Genrecom Laboratories, Ltd., Nanjing 210032, China
- Publication Type:Research Article
- Keywords:
italic>Salmonella;
tumor;
targeted therapy;
attenuation;
oncolytic bacteria
- From:
Acta Pharmaceutica Sinica
2024;59(1):17-24
- CountryChina
- Language:Chinese
-
Abstract:
italic>Salmonella has emerged as a promising tumor-targeting strategy in recent years due to its good tumor targeting ability and certain safety. In order to further optimize its therapeutic effect, scientists have tried to modify Salmonella, including its attenuation and drug loading. This paper summarizes the mechanism and research progress of Salmonella-mediated targeted tumor therapy, and introduces the strategies and related progress of its modification and optimization. At the same time, the advantages, current challenges and future development directions of Salmonella-mediated tumor therapy are summarized.
