Natural Products Treat Atopic Dermatitis via NF-κB Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20231838
- VernacularTitle:基于NF-κB信号通路天然产物治疗特应性皮炎的研究进展
- Author:
Xiang LI
1
;
Lingling DONG
1
;
Tao GUO
2
;
Litao ZHANG
2
Author Information
1. Graduate School，Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
2. Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital，Tianjin 300120，China
- Publication Type:Journal Article
- Keywords:
natural products;
atopic dermatitis;
nuclear factor-κB （NF-κB） signaling pathway;
review
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(4):271-280
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis （AD） is a chronic， recurrent， inflammatory， and pruritus skin disease caused by multiple internal and external factors， ranking first in the global burden of skin diseases. Due to the adverse reactions and high costs of conventional treatments and biologics， the development of natural products has attracted much attention. The nuclear factor-κB （NF-κB） signaling pathway is a key pathway for inhibiting inflammation and modulating immunity. This paper summarizes the pharmacological effects and molecular mechanisms of natural products such as flavonoids， alkaloids， phenols， terpenoids， coumarins， glycosides， and anthraquinones via NF-κB signaling pathway， aiming to provide guidance for the development of natural products. Basic studies have shown that natural products have high safety and efficacy. Oral or topical administration of natural products can regulate the phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt）， mitogen-activated protein kinase （MAPK）， nuclear factor erythroid 2-related factor 2 （Nrf2）， high mobility group box 1 protein （HMGB1）/receptor for advanced glycation endproducts （RAGE）， and nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） signaling pathways to exert anti-inflammatory， anti-allergy， antioxidant activities， thus reversing the pathological changes of AD. However， it is worth noting that the clinical application of natural products is still insufficient， and more rigorous clinical trials are still needed to verify their effects. The basic experiments and clinical evidence prove that natural products may play a role in alleviating AD， which provide a basis for evaluating the functioning mechanism of natural active substances and enrich the candidates for the development of potential drugs.
