Strategies for ABO-incompatible liver transplantation
10.3969/j.issn.1674-7445.2023187
- VernacularTitle:ABO血型不相容肝移植策略
- Author:
Xiaofeng ZHANG
1
;
Zhenyu ZHU
1
Author Information
1. Department of Hepatology Surgery, the Fifth Medical Center of the PLA General Hospital, Beijing 100039, China.
- Publication Type:ExpertForum
- Keywords:
ABO-incompatible liver transplantation;
Infection;
Antibody-mediated rejection;
Biliary complication;
Plasma exchange;
Immunosuppression;
Intravenous immunoglobulin;
Rituximab
- From:
Organ Transplantation
2024;15(1):33-39
- CountryChina
- Language:Chinese
-
Abstract:
With rapid development of organ transplantation, the issue of global organ shortage has become increasingly prominent. At present, liver transplantation is the most effective treatment for end-stage liver disease. Nevertheless, the shortage of donors has been a key problem restricting the development of liver transplantation. China is a country with a larger number of hepatitis B, and the shortage of donor liver is particularly significant. Many critically ill patients often lose the best opportunity or even die because they cannot obtain a matched donor liver in time. As a strategy to expand the donor pool, ABO-incompatible (ABOi) liver transplantation offers new options for patients who are waiting for matched donors. However, ABOi liver transplantation is highly controversial due to higher risk of complications, such as severe infection, antibody-mediated rejection (AMR), biliary complications, thrombotic microangiopathy, and acute kidney injury, etc. In this article, research progress in preoperative, intraoperative and postoperative strategies of ABOi liver transplantation was reviewed, aiming to provide reference for clinical application and research of ABOi liver transplantation.
