Current Status and Prospects of Screening for Newborn Hereditary Metaboolic Disease
10.12376/j.issn.2097-0501.2022.01.003
- VernacularTitle:中国新生儿遗传代谢病筛查现状及展望
- Author:
Xuefan GU
1
;
Lianshu HAN
1
;
Yongguo YU
1
Author Information
1. Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute for Pediatric Research, Shanghai 200092, China.
- Publication Type:Journal Article
- Keywords:
newborn screening;
hereditary metabolic disease;
dried blood spot;
tandem mass spectrometry;
genomic screening for newborns
- From:
JOURNAL OF RARE DISEASES
2022;1(1):13-19
- CountryChina
- Language:Chinese
-
Abstract:
Newborn screening is an effective measure for early detection and early treatment of rare genetic diseases. Among the three-level preventive measures to reduce birth defects, newborn screening has a significant preventive effect, and continues to develop with the advancement of new therapies and new technologies. Newborn screening is also relatively more reliable to obtain data on the prevalence of rare diseases. This article introduces the history and current status of neonatal screening for newborn hereditary metabolic disease in China, presents the disease spectrum and prevalence of 7 819 662 cases of neonatal screening by tandem mass spectrometry, and proposes 12 rare diseases as the primary targeting diseases for newborn screening by tandem mass spectrometry in China. At last, the article raises and discusses the issues of requirement for technology development and ethics of newborn screening.
