Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency
10.12376/j.issn.2097-0501.2023.03.016
- VernacularTitle:成人肾上腺皮质功能不全的激素替代治疗进展
- Author:
Xiaoxue CHEN
1
;
Ran LI
1
;
Huijuan ZHU
1
;
Lin LU
1
Author Information
1. Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
- Publication Type:Review
- Keywords:
adrenal insufficiency;
adult;
glucocorticoid;
modified-release hydrocortisone;
subcutaneous infusion pump
- From:
JOURNAL OF RARE DISEASES
2023;2(3):436-441
- CountryChina
- Language:Chinese
-
Abstract:
Adrenal insufficiency is a disease characterized by insufficient secretion of adrenocortical hormones, usually treated with glucocorticoid replacement therapy. The routine drugs have two forms-short-acting and long-acting. The shorter one should be taken 2-3 times a day resulting hormone level of patients fluctuating greatly within a day. Although long-acting drugs reduce the frequency of administration, it is easy to lead to excessive replacement, resulting in adverse effects on metabolism. New alternative treatments for adult patients have emerged, including modified-release hydrocortisone and hydrocortisone subcutaneous infusion pumps. In this review, we briefly introduce these new therapies, emphasizing the pharmacodynamics and pharmacokinetics of the replacement, the effects on metabolism and drug safety, aiming at contributing to the future clinical practice.
