Screening of hepatitis D virus in blood donors in Dalian
10.13303/j.cjbt.issn.1004-549x.2023.01.015
- VernacularTitle:大连地区献血者丁型肝炎病毒抗体的筛查
- Author:
Dan LIU
1
;
Dan WANG
1
;
Xiaochun LIU
1
;
Chunxiang LI
1
;
Liang ZANG
1
;
Xuelian DENG
1
Author Information
1. Dalian Blood Center, Dalian 116001, China
- Publication Type:Journal Article
- Keywords:
blood donor;
hepatitis D virus;
screening of HDV antibody
- From:
Chinese Journal of Blood Transfusion
2023;36(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the prevalence of hepatitis D virus in Dalian blood donors. 【Methods】 The samples reactive to HBV in blood screening were selected with the following confirmed results: 1)HBsAg+ &HBV DNA+ ; 2)HBsAg+ & HBV DNA-; 3)HBsAg-&HBV DNA+ ; 4)NAT-yield uncertain. Qualified samples in routine blood screening were additionally tested with anti-HBc+ and anti-HBs+. All samples selected were tested HDV IgG further. Initial reactive samples would be tested by another HDV IgG assay and HDV IgM assay. HDV IgG positive was confirmed when samples were reactive to two HDV IgG assays. 【Results】 None HDV antibodies were detected among 1 344 unqualified samples (507 HBsAg+ &HBV DNA+, 33 HBsAg+ &HBV DNA-, 477 HBsAg-&HBV DNA+ and 327 NAT-yield uncertain samples) or 766 qualified samples (397 anti-HBc+ and 369 anti-HBs samples) in blood screening. 【Conclusion】 The prevalence of HDV infections among Dalian blood donors eligible in pre-donation screening seemed extremely low. However, for areas with high HBV prevalence, the risk of blood safety caused by OBI co-infection with HDV should not be ignored.
