Research progress on cardiovascular toxicity associated with anti-tumor drugs and its prevention and treatment
10.16438/j.0513-4870.2023-0324
- VernacularTitle:抗肿瘤药物的心血管毒性及其防治的研究进展
- Author:
Ya-lin YANG
1
;
Yang HU
2
;
Jian-dong JIANG
1
;
Yu-hong WANG
1
;
Zhen-yu LIU
3
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
3. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
- Publication Type:Research Article
- Keywords:
anti-tumor drug;
cardiac toxicity;
vascular toxicity;
pathological mechanism;
prevention and treatment
- From:
Acta Pharmaceutica Sinica
2023;58(12):3539-3548
- CountryChina
- Language:Chinese
-
Abstract:
Cancer and cardiovascular diseases are the two major causes of death worldwide. The application of anti-tumor drugs has significantly improved the prognosis of patients, the cardiovascular toxicity caused by the application of them has become an important factor affecting the survival and prognosis of cancer patients. Therefore, the prevention and treatment of cardiovascular toxicity related to cancer treatment is increasingly important. The cardiovascular toxicity associated with anti-tumor drugs exhibits different clinical manifestations and involves multiple pathological mechanisms. This article reviews the current research progress from the perspective of the characteristics, molecular mechanisms and prevention and treatment strategies of cardiovascular toxicity caused by cancer drugs.
