Advances in applicaiton of platelets with cold storage at 4℃ and its storage lesion
10.13303/j.cjbt.issn.1004-549x.2021.08.034
- VernacularTitle:4℃冷藏保存血小板的储存损伤与应用研究进展
- Author:
Wenjuan LI
1
;
Rui HE
2
;
Yonghua YIN
2
;
Zhong LIU
3
Author Information
1. School of Public Health, Anhui Medical University, Hefei 230032, China
2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College
3. School of Public Health, Anhui Medical University, Hefei 230032, China; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College
- Publication Type:Journal Article
- Keywords:
cold storage;
platelet;
platelet storage lesion;
cryoprotectant;
platelet additive solution
- From:
Chinese Journal of Blood Transfusion
2021;34(8):926-930
- CountryChina
- Language:Chinese
-
Abstract:
Platelet transfusion is one of the important therapeutic methods for clinical prevention of bleeding and hemostasis. At present, agitated storage at (22±2)℃used for platelets leads to risk of bacterial growth, which limits platelet shelf life and safety in transfusion. Cold storage at 4 ℃ can significantly promote the abovementioned drawbacks and present a better hemostatic effect. Platelets storage lesion(PSL) due to the cold storage, however, may lead to platelet activation following transfusion, thus reducing the effective survival rate in vivo. This paper reviews the research advances in PSL and the application of platelets stored at 4 ℃.
