Extracellular vesicles in the blood components and their roles in transfusion-related immunomodulation
10.13303/j.cjbt.issn.1004-549x.2022.08.025
- VernacularTitle:成分血中的细胞外囊泡在输血相关免疫调节中作用的研究进展
- Author:
Yujie KONG
1
;
Xue TIAN
2
;
Li TIAN
2
;
Zhong LIU
2
Author Information
1. Laboratory Department of the First Affiliated Hospital of Chengdu Medical College, Chengdu 610599, China; Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences
2. Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College; Key Laboratory of Transfusion Adverse Reactions, Chinese Academy of Medical Sciences
- Publication Type:Journal Article
- Keywords:
extracellular vesicle;
blood component;
transfusion;
immunomodulation;
exosome;
microvesicle
- From:
Chinese Journal of Blood Transfusion
2022;35(8):877-881
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles (EVs) with a variety of bioactive molecules can be continuously secreted during the storage of blood components, which can promote cell-cell interaction and mediate cell-to-cell signal transmission. EVs are widely involved in inflammation, metabolism and immunization. In recent years, studies have reported that EVs in the blood components can not only cause transfusion-related lung injury through activating neutrophils, but also act on monocytes to stimulate inflammatory response. EVs can play different regulatory effects on the immune system of patients. In this review, the role and mechanism in transfusion-related immunomodulation (TRIM) of EVs in different blood components have been summarized.
