Research progress and future of red blood cell substitutes
10.13303/j.cjbt.issn.1004-549x.2022.08.002
- VernacularTitle:红细胞代用品研究进展与现状
- Author:
Jiaxin LIU
1
;
Chengmin YANG
1
Author Information
1. Institute of Blood Transfusion, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Chengdu 610052, China
- Publication Type:Journal Article
- Keywords:
red blood cell substitutes;
hemoglobin-based oxygen-carrying agents;
functional localization;
indications;
partial pressure of oxygen at half saturation(P50);
oxidative stress;
vasoactivity
- From:
Chinese Journal of Blood Transfusion
2022;35(8):785-790
- CountryChina
- Language:Chinese
-
Abstract:
This paper briefly reviewed blood substitutes, focusing on the background, history of research and development(R&D), types, functions, characteristics, the indications that will be mainly targeted in clinical, and their special status and role in the future, especially in the rescue of war/trauma patients using hemoglobin-based oxygen carriers(HBOCs). Additionally, the authors put forward unique insights and suggestions on some key concepts and R&D bottlenecks in the development of HBOCs through combining the authors′ own R&D experience for decades with efforts and lessons given by many scholars in this field at home and abroad, hoping to provide some new inspirations and ideas for colleagues to innovate and develop blood substitutes to benefit the clinical as soon as possible.
