Intervention of Chinese Herbal Medicine Formulas on Oxidative Stress of Chronic Obstructive Pulmonary Disease： A Review
10.13422/j.cnki.syfjx.20240392
- VernacularTitle:中药复方干预慢性阻塞性肺疾病氧化应激的研究进展
- Author:
Binbin HAO
1
;
Deting BA
1
;
Juan LI
2
;
Jintian LI
3
Author Information
1. Gansu Engineering Laboratory for New Products of Traditional Chinese Medicine （TCM）， Gansu Key Laboratory of TCM Excavation and Innovative and Transformation， Gansu University of Chinese Medicine，Lanzhou 730000，China
2. School of Basic Medicine of Gansu University of Chinese Medicine，Lanzhou 730101，China
3. Clinical College of TCM of Gansu University of Chinese Medicine，Lanzhou 730101，China
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicine formulas;
chronic obstructive pulmonary disease;
oxidative stress;
basic research;
clinical research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(3):218-225
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease （COPD） is a common disease in clinical practice. It is associated with obvious exposure to toxic particles or gases and has become the leading cause of death and disability worldwide. The pathogenesis of COPD is complex， and the oxidative stress involved in COPD plays a crucial role in the pathological process of the disease. Patients with COPD usually have high levels of oxidative stress in the lungs， which will affect the whole body for a long time， causing a variety of complications and accelerating the development of the disease. On the one hand， oxidative stress can directly damage the airway and lung tissue. On the other hand， it also drives other pathological mechanisms to jointly promote the development of disease， such as participating in inflammatory reactions and protease/anti-protease imbalance， promoting mucus secretion， accelerating cellular senescence， causing autoimmunity， and involving in genetic regulatory pathways. At present， western medicine treatment is mostly based on conventional drug treatment， and antioxidant-targeted oxidative stress is adopted， but there are still some challenges in efficacy and safety. Traditional Chinese medicine has a long history of preventing and treating COPD. In particular， Chinese herbal medicine formulas have great potential to interfere with the oxidative stress of COPD. Whether it is the modified classical traditional Chinese medicine or the new formulation developed by modern doctors， the research results reflect the multi-target and multi-channel advantages of traditional Chinese medicine treatment， and their efficacy and safety are gradually verified. This paper reviewed the literature in recent years， starting with the basic and clinical research on the intervention of traditional Chinese herbal medicine formulas on oxidative stress of COPD， so as to provide further ideas for related research on the prevention and treatment of oxidative stress of COPD by traditional Chinese medicine.
