Advances in mass-encoded probes for multiplex mass spectrometric detection
10.11665/j.issn.1000-5048.2023062902
- VernacularTitle:基于质量编码探针的质谱多联检测研究进展
- Author:
Hao YIN
1
;
Wei WANG
;
Qianhao MIN
Author Information
1. 南京大学生命分析化学国家重点实验室
- Publication Type:Journal Article
- Keywords:
mass-encoded probes;
mass spectrometric analysis;
multiplex detection
- From:
Journal of China Pharmaceutical University
2023;54(6):706-717
- CountryChina
- Language:Chinese
-
Abstract:
Mass-encoded probe is a probing tool that specifically identifies target molecules and thus outputs their characteristic ion signals with mass tags.It plays an important role in multiplex assay of disease markers, drug target screening and other biomedical applications.Based on various mass spectrometric methods, researchers have developed an array of mass tag-encoded probes with different structures and functions, providing powerful technical tools for multiplex detection of biomolecules in physiological environments and for mass spectrometry imaging of tissue samples.This review introduces the latest research progress of mass tag-encoded probes in multiplex mass spectrometric detection from three aspects, i.e. structural composition of the probes, mass spectrometric methods and their application in biochemical analysis, with a prospect of the future development of mass tag-encoded probes.
