Efficacy of different enteral nutrition drugs for severe acute pancreatitis and their gastrointestinal tolerance
- VernacularTitle:不同肠内营养制剂用于重症急性胰腺炎的疗效及胃肠道耐受性研究
- Author:
Xu CHEN
1
;
Yi DENG
1
;
Qiang LI
2
;
Di WU
3
Author Information
1. Dept. of Pharmacy，the Affiliated Women’s and Children’s Hospital，School of Medicine，University of Electronic Science and Technology of China/Chengdu Women’s and Children’s Central Hospital，Chengdu 611731，China
2. Pancreatic Center，Jiangsu Provincial People’s Hospital，Nanjing 210029，China
3. Dept. of Pharmacy，Jiangsu Provincial People’s Hospital，Nanjing 210029，China
- Publication Type:Journal Article
- Keywords:
enteral nutrition;
severe acute pancreatitis;
therapeutic efficacy;
tolerance;
adverse reaction
- From:
China Pharmacy
2023;34(24):3046-3050
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To compare the efficacy of different enteral nutrition （EN） drugs for severe acute pancreatitis （SAP） and their gastrointestinal tolerance. METHODS A total of 118 SAP patients admitted to the Pancreatic Center of Jiangsu Provincial People’s Hospital from January 1， 2022 to June 30， 2023 were collected and divided into short-peptide EN drugs （SP） group （41 cases）， dietary fiber-free intact protein EN drugs （TP-MCT） group （40 cases） and dietary fiber-containing intact protein EN drugs （TPF-DM） group （37 cases） according to the types of EN. All three groups of patients were given continuous pumps of EN drugs via nasal feeding for 24 hours， with a target energy dose of 25-30 kcal/kg. The blood nutritional indexes [albumin （ALB）， total protein （TP）， hemoglobin （Hb）， globulin （GLB）]， inflammation indexes [white blood cells （WBC）， percentage of neutrophils （N%）， procalcitonin （PCT）， C-reactive protein （CRP）， interleukin-6 （IL-6）]， clinical outcomes indexes [time of stay in the intensive care unit （ICU）， length of hospital stay， duration of resuming oral diet， the rate of cases without improvement， mortality rate] and the occurrence of gastrointestinal tolerance were collected from 3 groups before medication and 7 d after medication. RESULTS After treatment， ALB and TP in 3 groups were significantly higher than before treatment （P＜0.05）； CRP and N% of 3 groups， PCT of TP-MCT group and IL-6 of SP group were significantly lower than corresponding group before medication （P＜ 0.05）； PCT of TP-MCT group and IL-6 of SP group were significantly lower than those of other two groups at corresponding period （P＜0.05）. There were no statistical significances in ALB， TP， CRP or N% among the three groups after medication， and in Hb， GLB or WBC among the three groups before and after treatment （P＞0.05）. There was no significant difference in clinical outcome indexes among 3 groups （P＞0.05）. The incidence of gastrointestinal adverse reactions in the TP-MCT group was the lowest （32.50%）， and significantly lower than those in the SP group （46.34%） and TPF-DM group （48.65%） （P＜0.05）. CONCLUSIONS Different EN preparations can improve the nutritional status and reduce the inflammatory response in SAP patients to different extents， among which SP and TP-MCT are more effective， and TP-MCT shows the better gastrointestinal tolerance.
