BONE MINERAL DENSITY IN PATIENTS WITH HYPERTHYROIDISM
- VernacularTitle: ГИПЕРТИРЕОЗТОЙ ЭМЭГТЭЙЧҮҮДЭД ЯСНЫ НЯГТ ТОДОРХОЙЛСОН Н
- Collective Name:MNUMS;Department of Internal Medicine -I,Department of Pathology, Department of Internal Medicine -III
- Publication Type:Journal Article
- Keywords: Hyperthyroidism; hypothyroidism; T score; osteopenia; osteoporosis
- From:Innovation 2016;10(3):14-19
- CountryMongolia
- Language:Mongolian
- Abstract: Hyperthyroidism is associated with accelerated bone remodeling, reduced bone density, osteoporosis and an increase in fracture rate. In the statistical report of Center for Health Development, in 2015, there were 4960 female patients with thyrotoxicosis (E05) registered which more than 589 female patients with hypothyroidism (E00-E02). Therefore, we studied bone mineral density changes due to thyroid dysfunction in female patients. In the study 48 reproductive age female patients were participated. 24 of them were evaluated as relatively healthy patients and 24 of them were diagnosed by laboratory test with hyperthyroidism. The risk factors of osteoporosis were evaluated by questionnaires and bone mineral density was evaluated by bone sonometer. We determined serum level of TSH, fT3 and fT4 (TSH, fT3, fT4 TOSOH Corporation, Tokyo, Japan) and calcitonin (Calcitonin ELISA Kit, Eucardio laboratory, CA, USA). Results were calculated by SPSS-17 program. Total 48 patients ranging 18-45 years old (average age was 33.3±4.2 in control group and 32.2±6.7 in hyperthyroid group) were participated. As evaluating the osteoporosis diagnostic criteria of WHO, result for the control group was 92% (n=22) patients were healthy, 8% (n=2) patients had osteopenia and; 54% (n=13) was healthy, 25% (n=6) had osteopenia and 21%-д (n=5) had osteoporosis in hyperthyroid group. In the control group, T score mean was 1.3±1.3 (-1.9-(+2.5)) healthy to osteopenia and; -0.9±2.1 (-5.3-(+2.0)) healthy to osteoporosis in hyperthyroid group. Comparison of T score between control and hyperthyroid group, there were statistically relevant (p<0.05). The average of Speed of sound (SOS) were 4188.8±145.3 m/sec (3975-4467 m/sec) in control group and 4073.8±238.0 m/sec (3579-4530 m/sec) in hyperthyroid group. Comparison of SOS between control and hyperthyroid group, there were statistically relevant (p<0.05). TSH, fT3 and fT4 have correlation with bone mineral density between control and hyperthyroid group (p<0.05) but, calcitonin do not have correlation between as 2 groups p>0.05. Depending on serum level of TSH, fT3 and fT4, bone mineral density was decreased more in patients with hyperthyroidism.