The Expression of Programmed Death-Ligand 1 on Immune Cells Is Related to a Better Prognosis in Biliary Tract Cancer
- Author:
Sung Chan KWON
1
;
Seungmin BANG
;
Young Nyun PARK
;
Ji Hoon PARK
;
So Jeong KIM
;
Jung Hyun JO
;
Moon Jae CHUNG
;
Jeong Youp PARK
;
Seung Woo PARK
;
Si Young SONG
;
Eunhyang PARK
;
Hee Seung LEE
Author Information
- Publication Type:Original Article
- From:Gut and Liver 2023;17(6):933-941
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:Programmed death-ligand 1 (PD-L1) expression in tumor cells is associated with a poor biliary tract cancer (BTC) prognosis; tumor-infiltrating immune cells in the tumor microenvironment are associated with a better prognosis. The effect of PD-L1 expression on immune cells on survival is unclear. We investigated the relationship between PD-L1 expression in immune cells and BTC prognosis.
Methods:PD-L1 expression was evaluated using an anti-PD-L1 22C3 mouse monoclonal primary antibody, and its relationships with clinical characteristics and prognosis were analyzed using the Cox proportional hazard model to investigate the prognostic performance of PD-L1 in BTC.
Results:Among 144 analyzed cases, patients with positive PD-L1 expression in tumor cells and negative PD-L1 expression in immune cells showed poorer overall survival rates than those exhibiting other expressions (tumor cells: hazard ratio [HR]=1.023, p<0.001; immune cells: HR=0.983, p=0.021). PD-L1 expression in tumor cells was an independent predictor of poor overall survival (HR=1.024, p<0.001). In contrast, PD-L1 expression in immune cells was a predictive marker of good prognosis (HR=0.983, p=0.018).
Conclusions:PD-L1 expression in immune cells may be used as an independent factor to evaluate the prognosis of patients with BTC.
