1.Insulin-like Growth Factors and Nutrition.
Journal of the Korean Pediatric Society 2001;44(3):235-241
No abstract available.
Somatomedins*
2.The Role of Insulin-Like Growth Factors in Central Nervous System.
Journal of Korean Society of Pediatric Endocrinology 2000;5(1):28-34
No abstract available.
Central Nervous System*
;
Somatomedins*
3.Insulin-like Growth Factors and Dermatosis.
Hong Yan TANG ; Bin XIAO ; Li Ping WANG ; Gui Lan YANG
Acta Academiae Medicinae Sinicae 2019;41(3):415-418
Insulin-like growth factors(IGFs)are polypeptides structurally homologous to insulin.By binding to membrane tyrosine receptors,they regulate the proliferation,differentiation,apoptosis,growth,and development of body cells and are involved in the pathogenesis of tumors and other diseases.In recent years,more research on IGFs of dermatosis increased.This article reviews recent research advances in IGFs and its relationship with dermatosis.
Humans
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Peptides
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Skin Diseases
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Somatomedins
4.Plasma somatomedin C levels in normal children.
Jung Tak KIM ; Ho Seong KIM ; Duk Hi KIM
Journal of the Korean Pediatric Society 1992;35(11):1493-1500
No abstract available.
Child*
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Humans
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Insulin-Like Growth Factor I*
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Plasma*
;
Somatomedins*
5.Research progress on the influence mechanism of insulin like growth factors system on growth restriction.
Acta Academiae Medicinae Sinicae 2011;33(1):18-21
Insulin-like growth factors (IGF) system plays an important role in regulating growth and development of children. The change of this system is closely related to growth restriction caused by various diseases. This article reviews the research progress on how IGF system affects growth.
Developmental Disabilities
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metabolism
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physiopathology
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Humans
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Somatomedins
;
metabolism
;
physiology
6.Research on expression of somatomedin b domain of proteoglycan 4 and recombinant protein aggregation.
Lifang WANG ; Zhibo HAN ; Wenhu CHEN ; Peng DU ; Aihua SUN ; Ping YANG ; Hongguang ZHAO
Journal of Biomedical Engineering 2014;31(6):1319-1324
Recombinant protein SMB(PRG4) containing two Somatomedin B domains and a small amount of glycosylation of repetitive sequences of proteoglycan 4 was cloned according to PGR4 gene polymorphism. Mature purification process was established and recombinant protein SMB(PRG4), with high-level expression was purified. By using size-exclusion chromatogaraphy and dynamic light scattering, we found that the recombinant protein self-aggregate to dimeric form. Structure prediction and non-reducing electrophoresis revealed that SMB(PRG4), was a non-covalently bonded dimer.
Glycosylation
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Protein Multimerization
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Proteoglycans
;
chemistry
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Recombinant Proteins
;
chemistry
;
Somatomedins
;
chemistry
8.Plasma Somatomedin in Children with Perthes' Disease
The Journal of the Korean Orthopaedic Association 1985;20(2):213-218
No abstract available in English.
Child
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Humans
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Legg-Calve-Perthes Disease
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Plasma
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Somatomedins
9.Growth hormone, somatomedin C levels in umbilical cord blood in premature, term, postterm neonates.
Kyung Ho LIM ; Myung Chul SHIN ; Yong Won PARK ; In Kyu KIM ; Chan Ho SONG
Korean Journal of Obstetrics and Gynecology 1993;36(7):1769-1774
No abstract available.
Fetal Blood*
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Growth Hormone*
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Humans
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Infant, Newborn*
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Insulin-Like Growth Factor I*
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Somatomedins*
;
Umbilical Cord*
10.Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms.
Chinese Journal of Contemporary Pediatrics 2011;13(9):767-771
Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
Bone Development
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Cytokines
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physiology
;
Enteritis
;
complications
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Growth Disorders
;
etiology
;
Human Growth Hormone
;
physiology
;
Humans
;
Somatomedins
;
physiology