1.Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report
Rahul KUMAR ; John Chen HSIANG ; Jessica TAN ; Prem Harichander THURAIRAJAH
Clinical and Molecular Hepatology 2019;25(3):326-330
No abstract available.
Drug-Induced Liver Injury
;
Ribavirin
2.Can Non-invasive Fibrosis Assessment Predict Sustained Virological Response to Telaprevir with Pegylated Interferon and Ribavirin in Chronic Hepatitis C Patients?.
Mi Na KIM ; Jun Hyung KIM ; Seung Up KIM
The Korean Journal of Gastroenterology 2014;64(4):250-252
No abstract available.
Fibrosis*
;
Hepatitis C, Chronic*
;
Humans
;
Interferons*
;
Ribavirin*
3.High dose-short duration ribavirin aerosol therapy compared with standard ribavirin therapy in children with suspected respiratory syncytial virus infection.
Young Min AHN ; Janet A ENGLUND ; Pedro A PREDRA ; Brian E GILBERT ; Peter HIATT
Pediatric Allergy and Respiratory Disease 1993;3(2):103-118
No abstract available.
Child*
;
Humans
;
Respiratory Syncytial Viruses*
;
Ribavirin*
4.Short-term outcomes of the use of intraventricular ribavirin in Filipino patients with subacute sclerosing panencephalitis.
Marissa B. LUKBAN ; Aida M. SALONGA ; Judy R. PIPO-DEVEZA ; Benilda C. SANCHEZ-GAN ; Catherine Lynne T. SILAO ; Annabell E. CHUA
Acta Medica Philippina 2022;56(9):76-83
Background. Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease caused by prolonged persistent infection of the central nervous system with a measles virus mutant. Though various treatment modalities have been tried, there is no effective treatment to completely cure SSPE and new therapeutic strategies are needed.
Objective. This is a prospective uncontrolled observational open label trial to describe the short-term outcomes and safety of intraventricular ribavirin in combination with oral isoprinosine in Filipino SSPE patients.
Methods. Sixteen (16) unrelated SSPE patients between ages 3-26 years and in various clinical stages were included in this study. Demographic data were described. Intraventricular instillation of ribavirin (1-3 mg/kg/dose) through an Ommaya reservoir was given for a duration of 3-6 months in 13 patients. The duration of follow-up was 48 weeks. The clinical outcome was assessed before, during, and after treatment using the Neurological Disability Index (NDI), Brief Assessment Examination (BAE), and clinical staging using the Jabbour Classification. Adverse side effects from intraventricular ribavirin were enumerated.
Results. Six of 13 (46.15%) patients mostly in Stage III illness had clinical improvement showing decreasing NDI and BAE scores during treatment and the clinical improvement was maintained or improved further during the 48-week follow-up period. Clinical improvement manifested as improved mental alertness, decrease in spasticity and reduction of seizures. The clinical staging of those who improved remained stable during and after treatment was discontinued. Five (38.46%) patients in Stage II disease worsened and progressed to Stage III despite ribavirin therapy including 1 (7.6%) patient who died after the treatment phase due to pneumonia and brainstem failure. The clinical course of two (15.38%) patients remained unchanged. Minor adverse side effects of ribavirin included transient fever, rash, oral sores, seizure episodes, drowsiness, bladder retention and mild increase in transaminases. Ommaya reservoir infection was a serious adverse event in 5 (31.25%) patients.
Conclusion. There is still no definitive cure for SSPE. Although ribavirin may help alleviate some of the symptoms of SSPE and prolong life, it may not reverse or halt the progression of the disease. Long term follow-up of these patients and continuous use of intraventricular ribavirin will better clarify its role in modifying the fatal course of SSPE. The role of ribavirin in Stage I patients and a controlled clinical trial in Stage II SSPE needs further studies.
Subacute Sclerosing Panencephalitis ; Ribavirin ; Measles virus
5.Sarcoidal Reaction on Old Scars during Pegylated Interferon-α and Ribavirin Therapy in a Patient with Chronic Hepatitis C.
Soo Hyun KIM ; Kyu Suk LEE ; Byung Ho OH ; Sung Ae KIM
Korean Journal of Dermatology 2017;55(2):149-151
No abstract available.
Cicatrix*
;
Hepatitis C, Chronic*
;
Hepatitis, Chronic*
;
Humans
;
Interferons
;
Ribavirin*
6.Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp..
Yan Lai JIA ; Fei Fei GUAN ; Jie MA ; Chang Yun WANG ; Chang Lun SHAO
Natural Product Sciences 2015;21(4):227-230
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3 and 4), along with 5'-O-acetyl uridine (5) first isolated as a natural product. The structure of the new compound (1) was established by comprehensive spectroscopic analysis and chemical methods. Compounds 1 - 4 possessed varying degrees of antiviral activities, which was reported for the first time. Compared to the positive control ribavirin (IC50 = 418.0 microM), pestalotiolide A (1) exhibited significant anti-EV71 activity in vitro, with an IC50 value of 27.7 microM. Furthermore, the preliminary structure-activity relationship of antiviral activities was also discussed.
Fermentation
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Fungi*
;
Inhibitory Concentration 50
;
Ribavirin
;
Structure-Activity Relationship
;
Uridine
7.Acute Pancreatitis Associated with Pegylated Interferon alpha-2b and Ribavirin Treatment of Chronic Hepatitis C.
Seong AHN ; Yo Han KU ; Sang Yoon HA ; Rim LEE ; Cheol KOO
Soonchunhyang Medical Science 2014;20(2):99-102
Acute pancreatitis is an uncommon side effect of pegylated interferon (PEG-IFN) alpha-2b and ribavirin (RBV) combination therapy. In South Korea, There is a no report of acute pancreatitis associated PEG-IFN alpha-2b plus RBV combination therapy. Here, acute pancreatitis associated with PEG-IFN alpha-2b plus RBV treatment is described in two patients with chronic hepatitis C. We started on weekly subcutaneous injection of PEG-IFN alpha-2b plus daily RBV. During this therapy, acute pancreatitis occurred in these patients without other causes of acute pancreatitis. We thought that the cause of acute pancreatitis in these patients was PEG-IFN alpha-2b and RBV. We stopped the treatment of PEG-IFN alpha-2b and RBV, and patients were improved.
Hepatitis C, Chronic*
;
Humans
;
Injections, Subcutaneous
;
Interferons*
;
Korea
;
Pancreatitis*
;
Ribavirin*
8.Antiviral Therapy in Patients after Treatment for Hepatitis C-Related Hepatocellular Carcinoma.
Su Rin SHIN ; Seung Woon PAIK ; Geum Youn GWAK ; Moon Seok CHOI ; Joon Hyoek LEE ; Kwang Cheol KOH ; Byung Chul YOO
Gut and Liver 2011;5(1):77-81
BACKGROUND/AIMS: Despite great progress, antiviral treatment for chronic hepatitis C in patients with prior hepatocellular carcinoma (HCC) has been rarely investigated. We evaluated the efficacy and safety of antiviral therapy following treatment for hepatitis C-related HCC. METHODS: Thirteen patients (age 34 to 60 years) who were treated with peginterferon plus ribavirin after treatment for HCC were reviewed. RESULTS: There were 6 patients with genotype 1 and 7 patients with genotype 2. All patients showed advanced fibrosis (> or =F3) but belonged to the Child-Pugh class A. Treatment was stopped in 2 patients because of recurrent HCC and in 1 patient due to a lack of early virologic response. Seven patients achieved sustained virologic response and three patients relapsed. The sustained virologic response rate was 54% overall, 17% in genotype 1, and 86% in genotype 2. No significant adverse events were reported. CONCLUSIONS: Antiviral therapy should not be excluded in patients who were previously treated with HCC with genotype 2 chronic hepatitis C, in which an efficacious antiviral treatment for chronic hepatitis C was feasible. Additional study is needed to prove the validity of antiviral therapy in patients with genotype 1 hepatitis C-related HCC.
Carcinoma, Hepatocellular
;
Fibrosis
;
Genotype
;
Hepatitis
;
Hepatitis C, Chronic
;
Humans
;
Ribavirin
9.Does the old-fashioned sofosbuvir plus ribavirin treatment in genotype 2 chronic hepatitis C patients still works for Koreans?.
Clinical and Molecular Hepatology 2018;24(3):294-296
No abstract available.
Genotype*
;
Hepatitis C, Chronic*
;
Hepatitis, Chronic*
;
Ribavirin*
;
Sofosbuvir*
10.Simeprevir-Based Triple Therapy with Reduced Doses of Pegylated Interferon α-2a Plus Ribavirin for Interferon Ineligible Patients with Genotype 1b Hepatitis C Virus.
Hideyuki TAMAI ; Yoshiyuki IDA ; Akira KAWASHIMA ; Naoki SHINGAKI ; Ryo SHIMIZU ; Kosaku MORIBATA ; Tetsushi NASU ; Takao MAEKITA ; Mikitaka IGUCHI ; Jun KATO ; Taisei NAKAO ; Masayuki KITANO
Gut and Liver 2017;11(4):551-558
BACKGROUND/AIMS: The present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic patients, and to elucidate the factors contributing to a sustained virologic response (SVR). METHODS: One hundred IFN ineligible patients infected with genotype 1b hepatitis C virus (HCV) were treated. Simeprevir (100 mg) was given orally together with reduced doses of PEG-IFN-α 2a (90 μg), and ribavirin (200 mg less than the recommended dose). RESULTS: The patients’ median age was 70 years, and 70 patients were cirrhotic. Three patients (3%) discontinued treatment due to adverse events. The SVR rate was 64%. Factors that significantly contributed to the SVR included the γ-glutamyl transferase and α-fetoprotein levels, interleukin-28B (IL28B) polymorphism status, and the level and reduction of HCV RNA at weeks 2 and 4. The multivariate analysis showed that the IL28B polymorphism status was the only independent factor that predicted the SVR, with a positive predictive value of 77%. CONCLUSIONS: Simeprevir-based triple therapy with reduced doses of PEG-IFN and ribavirin was safe and effective for IFN ineligible patients infected with genotype 1b HCV. IL28B polymorphism status was a useful predictor of the SVR.
Aged
;
Genotype*
;
Hepacivirus*
;
Hepatitis C*
;
Hepatitis*
;
Humans
;
Interferons*
;
Multivariate Analysis
;
Ribavirin*
;
RNA
;
Simeprevir
;
Transferases