No abstract available.
Photochemotherapy* ; Porokeratosis*

The effects of photodynamic therapy (PDT) on the 180-sarcom tumors in some days after treatment were studied at the photo microscope and electro-microscope levels in BALB/c mice bearing 180 sarcom tumors. Animals received intravenous injection of 10 mg/kg of Photofrin and 24h later tumors were treated with 200-350 J/cm2 gold vapor laser light (630 nm). Animals were sacrificed and their tumors removed at time 24, 48, 72h and 7, 14, 21 days after PDT. The results indicated the effects of destruction of the 180-sarcom cells
Neoplasms ; Photochemotherapy

No abstract available.
Photochemotherapy ; Porokeratosis

Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.
Humans ; Light ; Photochemotherapy ; Triazenes

No abstract available.
Carcinoma, Basal Cell* ; Photochemotherapy*

ABSTRACT Lactobacillus acidophilus (L. acidophilus) is one of the etiological agents for dental caries and dominant in the deep carious lesion. L. acidophilus has also been identified in persistent root canal infection and also related to the failure of endodontic treatment. Photodynamic therapy is a therapeutic process involving the combination of a nontoxic photosensitizer and a light source. The excited photosensitizer reacts with reactive oxygen species (ROS), which induce injury and death of the microorganism. This study aimed to prove the effect of irradiation time of photodynamic therapy to the number of L. acidophilus. Forty-two Eppendorf tubes were treated with 0.5 ml L. acidophilus distributed into seven groups. Group 1 as the control group received no treatment. Groups 2, 3, 4, 5, 6 and 7 were treated with a combination of 0.5 ml toluidine blue O (TBO) as a photosensitizer and 630 nm photoactivated (Fotosan®) exposure time for 10, 20, 30, 40, 50 and 60 sec. Then, all were stored in an incubator of 37ºC for 48 h. Later, the colony-forming unit (CFU) was counted for each group. There were significant differences in the number of L. acidophilus in CFU of the various irradiation times. The longer the photodynamic therapy irradiation was, the lesser the number of live L. acidophilus became. At 50 sec and 60 sec irradiation, none of the L. acidophilus was found alive.
Photochemotherapy ; Lactobacillus acidophilus

No abstract available.
Carcinoma, Squamous Cell ; Chlorine ; Photochemotherapy

No abstract available.
Paget Disease, Extramammary* ; Photochemotherapy* ; Radiotherapy*

Objectives: The aim of this review was to examine the effects of PDT in the treatment of neovascular ARMD.
PHOTOCHEMOTHERAPY ; RETINAL NEOVASCULARIZATION ; MACULAR DEGENERATION

OBJECTIVES: The purpose of this study was to provide photodynamic bactericidal effect against Enterococcus faecalis by erythrosine concentrations and LED irradiation times. METHODS: Erythrosine was used as a photosensitizer and green LED (3 Watt, 520-530 nm) was used as light source. E. faecalis ATCC 1943 and E. faecalis ATCC 29212 were used in this study. Approximately 10(5) CFU of bacteria were added in wells of a 96-well microtitration plate. For examining the effects of concentrations of erythrosine, 0, 0.625, 1.25, 2.5, 5, and 10 microM of erythrosine were added in wells containing bacteria. The irradiation time with LED was 30 sec. In another set of experiment, the effect of irradiation time for killing of bacteria was investigated by increasing irradiation time from 0 to 30 s with 10 microM of erythrosine final concentration. After irradiation, each sample was serially diluted with PBS and 50 microl of diluents was spread on duplicate blood agar plates. The plates were incubated for 72 h at 37degrees C under aerobic conditions and the number of CFU was determined. The experiments were repeated four times. The results were analyzed using one-way ANOVA, and Tukey's multiple comparison at a significance level of 0.05. RESULTS: When the erythrosine concentrations were more than 2.5 microM, E. faecalis ATCC 29212 was significantly decreased (P<0.05). The more erythrosine concentrations increased, the more E. faecalis ATCC 1943 decreased statistically significantly (P<0.05). In another set of experiment, when LED irradiation time was more than 20 s, E. faecalis ATCC 1943 decreased significantly (P<0.05), and if the irradiation times was more than 5 s, E. faecalis ATCC 29212 decreased significantly (P<0.05). CONCLUSIONS: PDT using erythrosine and green LED was found to be an effective method in killing E. faecalis.
Agar ; Bacteria ; Enterococcus faecalis* ; Erythrosine* ; Homicide ; Photochemotherapy