Physiological and biochemical studies were conducted to ascertain the nature and mechanism of Reserpine relaxing action on uterine muscle. Various animal and human myometrial specimens were utilized involving in vitro, in vivo and manometric setupsWhile Reserpine and the catechol amines, Epinephrine and Norepinephrine, similarly inhibit uterine contractions, the effects of the Rauwolfia alkaloid cannot be due to release and mediation of the latter autonomic agents. Experimental proofs offered include: (a) Reserpine effects are not prevented nor significantly diminished by adrenergic blocking agents such as Phentolamine and Guanethidine; (b) In pregnant cats, the catechol amines exhibit a stimulant action on the uterus. Reserpine administration elicits the usual inhibitory effect under such conditionReserpine inhibitory effects on the myometrial tissues are elicited directly on the effector contractile mechanisms. Specific pharmacological antagonism of smooth muscle agonists such as Ergonovine, Posterior Pituitary Injection, Oxytocin, Barium, etc. are consistently observed indicating a musculotrophic actionReserpine inhibits significantly and uniformly the oxygen consumption of uterine tissues as borne out by direct Warburg manometry. There appears to be a qualitative correlation between myometrial inhibition and this biochemical phenomenon. (Summary and Conclusions)
Myometrium, Reserpine

No abstract available.
Animals ; Female ; Mice ; Myometrium* ; Rats*

Gartner duct cysts are relatively common congenital cysts in the anterolateral wall of the vagina. Most are small (less than 2 cm) and asymptomatic, but larger cysts may cause problems. We report a rare case of a giant Gartner duct cyst (7 cm) originating from the right lateral portion of the uterine cervix and adjacent myometrium. It appeared as an exophytic multiseptated cystic mass containing different density fluids on CT.
Animals ; Cervix Uteri ; Female ; Mice ; Myometrium ; Vagina

Uterine leiomyomas are benign tumors arising from the myometrium and largely prevalent in the woman's reproductive years. The majority of women with leiomyomas either remain asymptomatic or develop symptoms gradually over time. When patients are symptomatic, the nature of their complaints is often attributable to the number, size, and/or location of their fibroids. Depending on a patient's symptomatology and reproductive plans, treatment options include expectant management, medical management (hormonal and non-hormonal), or surgical management (myomectomy or hysterectomy).
Animals ; Female ; Humans ; Leiomyoma* ; Mice ; Myometrium

Background: The Lead Vessel and Infitrating Vessels are findings in endometrial cancer that are well visualized by three-dimensional power Doppler angiography. Vessel diameter and length may be utilized as markers for deep myometrial and or cervical involvement. Objective: To determine the accuracy of Lead vessel and Infiltrating vessel dimensions in assessing the depth of myometrial invasion in endometrial cancer and its cervical involvement. Participants and Methods All women histopathologically diagnosed with endometrial cancer, undergoing surgical staging, with informed consent were included. Sonography using GE Voluson S8 system for describing the uterus and endometrial thickness were followed by a 3D power Doppler Angiography to analyze the depth of myometrial invasion and presence or absence of cervical involvement. Vessel diameter and length in transverse and sagittal plane were measured by calipers. Predictive values and operating characteristics (sensitivity, specificity, positive and negative predictive values) were computed.
Myometrium ; Endometrial Neoplasms ; Angiography ; Ultrasonography, Doppler

Endometrial stromal sarcomas (ESS) of the myometrium compose just 0.2% of uterine malignant tumors. In terms of their cellular mitotic activities, they are named as low grade or high grade ESS. As low grade ESS are very rare, we would like to report our 3 cases with immunohistochemical stain method, treatment option as the disease progression and the brief review of literature.
Animals ; Disease Progression ; Female ; Mice ; Myometrium ; Sarcoma, Endometrial Stromal*

OBJECTIVE: To evaluate the association of level of CA-125 and severity of dysmenorrhea with lesion depth in adenomyosis. METHODS: Sixty-eight women who had undergone hysterectomy and were found to have pure adenomyosis on histopathologic examination were reviewed retrospectively. Specimens were stratified according to the degree of adenomyosis penetration into 4 groups: group A consisted of specimens with adenomyosis penetration into myometrium of up to 25%; group B, 26-50%; group C, 51-75%, and group D, >75%. All women were submitted to serum determination of CA-125. Severity of dysmenorrhea was assessed by means of a modification of 10-point verbal rating scale. RESULTS: Each group was not correlated with severity of dysmenorrhea (p=0.7394 Fisher's exact test). The means of serum CA-125 levels was increased corresponding to depth of adenomyosis (p=0.0441 ANOVA test). CONCLUSION: In this study, serum CA-125 level is associated with the depth lesion and severity of dysmenorrhea is not. Therefore, the level of serum CA-125 might be useful indicator in management of adenomyosis before surgery.
Adenomyosis* ; Animals ; Dysmenorrhea* ; Female ; Humans ; Hysterectomy ; Mice ; Myometrium ; Retrospective Studies

Postpartum endomyometritis is an important cause of maternal morbidity, especially after cesarean delivery. The management of postpartum endomyometritis is primarily medical with surgical intervention only occasionally required. But the gas forming abscess rarely happens, making the medical treatment difficult and needing emergency hysterectomy. We present a case of post-cesarean delivery endomyometritis complicated by intrauterine gas formation penetrating myometrium, which could not be managed by medical treatment, so finally needed emergency hysterectomy.
Abscess ; Animals ; Emergencies ; Endometritis* ; Female ; Hysterectomy ; Mice ; Myometrium ; Postpartum Period

The clinical and pathological features of an apparently unique case of an adenomyoitc cyst of the uterus are reported. The cyst was located within the myometrium of a 30-year-old woman suffering from vaginal bleeding for 6 months. Saline infusion sonohysterography revealed uterine cyst. After excision of the cyst, patient's symptoms improved. On histological examination, the cyst most closely resembled an adenomyotic cyst.
Adenomyoma* ; Adult ; Animals ; Female ; Humans ; Mice ; Myometrium ; Uterine Hemorrhage ; Uterus

To elucidate the endocrine mechanism of human parturition, the expression of c-Jun and c-Fos mRNA were examined in relation to estrogen receptor (ER) and progesterone receptor (PR) in human myometrium. c-Jun mRNA was detected in all myometrial tissues (n=5) during labor but not before labor (n=5) and in oxytocin-resistant postterm pregnancy (n=3). c-Fos mRNA was detected in only one myometrial tissue from a woman in labor. The distribution and intensity of immunostaining for ER and PR were semiquantitatively scored. During the late pregnancies, no significant difference was seen in the receptor scores for myometrial ER and PR between the patients who experienced labor and those who did not. Receptor scores for ER and PR were significantly lower in postterm pregnancy than in late pregnancy, regardless of the labor status. These data suggest that there are no changes in ER and PR in human myometrium during parturition. On the other hand, postterm pregnancy is associated with low ER and PR. c-Jun, induced during labor without changes in ER and PR, may play a role as a signaling mechanism in human myometrium.
Adult ; Blotting, Northern ; Female ; Genes, jun/genetics* ; Human ; Immunohistochemistry ; Labor/metabolism* ; Myometrium/metabolism* ; Myometrium/cytology ; Pregnancy ; RNA, Messenger/analysis ; Receptors, Estrogen/metabolism* ; Receptors, Progesterone/metabolism* ; Reference Values