No abstract available.
Catatonia* ; Lorazepam* ; Seizures*

No abstract available.
Antiemetics* ; Cisplatin* ; Dexamethasone* ; Humans ; Lorazepam* ; Metoclopramide* ; Ondansetron*

In a double blind study, 32 patients were randomly divided into three treatment groups, namely, placebo, 1 tablet b.i.d., lorazepam 0.5 mg. b.i.d., and lorazepam 1.0 mg. b.i.dCoefficient of regression analysis during the first three weeks of treatment showed significantly faster improvement in both lorazepam groups compared with placebo. With the fourth week included, statistically significant difference was attained only with lorazepam 1.0 mg. b.i.d. compared with placebo. Side effects were seen in 10 patients, including 3 placebo patients; these either promptly responded to reduction in dosage or were transitory without change in dosageLaboratory data before treatment were not significantly different from post-treatment values. Laboratory data before and after treatment showed no evidence of drug toxicityThe efficacy of lorazepam even at low doses of 0.5 mg. b.i.d. and 1.0 mg. b.i.d. attests to its potency as an anti-anxiety agent. (Summary)
Patients, Lorazepam, Placebos, Tranquilizing Agents, Minor

The study tested the anti-anxiety activity of lorazepam through the conflict test and the "fighting mice" test. Different compounds were given test animals at differnt dose levels. Results from conflict test revealed that lorazepam is more potent than diazepam. "Fighting mice" test showed that of the four benzodiazepines tested, lorazepam caused a reduction to zero fight at a dose of 2 mg/kg. Both measures proved that lorezepam posesses anti-anxiety properties. The anti-anxiety properties of loraxepam has since been confirmed in humans through extensive clinical trials
Animals, Drug Therapy, Lorazepam, Diazepam, Benzodiazepines

Drugs of the benzodiazepine family pharmacologically have superior anti-anxiety, sedative, anti-convulsant, and muscle relaxant effect resulting in its popular use not only in psychiatry but in other field of medicine. However, the long term use of benzodiazepines may cause to question the efficacy and may amount to dependence, tolerance, and withdrawal symptoms thus leading to sociologic problems. The treatment strategies of benzodiazepine dependence consist of gradual dosage reduction, the substitution to a long half-life benzodiazepine, and providing psychological support. We present two treatment experiences of high dose lorazepam dependence along with the review of corresponding literature.
Benzodiazepines ; Half-Life ; Humans ; Lorazepam* ; Substance Withdrawal Syndrome

Status epilepticus is a neurological emergency requiring immediate effective care to avoid permanent brain damage or death. There is no single ideal pharmacological agent that can be used for status epilepticus. The author has studied the effect of intravenous lorazepam in the tratment of status epilepticus occurring in eighteen patients. Lorazepam controlled status epilepticus in sixteen (88%) of the eighteen patents, showed no side effect such as depressant action on respiratory and cardiovascular system. Also it seemed that lorazepam acted rapidly and its effect lasted at least for over eight hours. Except a few cases who had had prolonged hangover, the injection seemed to be handy and safe treatment without requiring EKG monitoring and repeated electrolyte check etc. as in dilantinization.
Brain ; Cardiovascular System ; Electrocardiography ; Emergencies ; Humans ; Lorazepam* ; Phenytoin ; Status Epilepticus*

Status epilepticus is a neurological emergency requiring immediate effective care to avoid permanent brain damage or death. There is no single ideal pharmacological agent that can be used for status epilepticus. The author has studied the effect of intravenous lorazepam in the tratment of status epilepticus occurring in eighteen patients. Lorazepam controlled status epilepticus in sixteen (88%) of the eighteen patents, showed no side effect such as depressant action on respiratory and cardiovascular system. Also it seemed that lorazepam acted rapidly and its effect lasted at least for over eight hours. Except a few cases who had had prolonged hangover, the injection seemed to be handy and safe treatment without requiring EKG monitoring and repeated electrolyte check etc. as in dilantinization.
Brain ; Cardiovascular System ; Electrocardiography ; Emergencies ; Humans ; Lorazepam* ; Phenytoin ; Status Epilepticus*

Drug-assisted interviews are useful for psychiatric diagnosis and treatment. However, amobarbital, a typical medication used for this purpose, is associated with elevated risk of respiratory depression. Benzodiazepines are good substitutes for amobarbital, with similar therapeutic effects and fewer complications. Although drug-assisted interviews are not widely used, they may be beneficial for selected patients who do not respond to conventional treatments such as supportive psychotherapy or psychopharmacotherapy. We report two cases of dissociative amnesia that were treated using lorazepam-assisted interviews. The use of lorazepam in drug-assisted interviews is effective and safe for resolving dissociative amnesia.
Amnesia ; Amobarbital ; Benzodiazepines ; Humans ; Lorazepam ; Mental Disorders ; Psychotherapy ; Respiratory Insufficiency

The effects of lorazepam on cerebral function, metabolism, and hemodynamics were studied in eight dogs receiving a general anesthesia with isoflurane(0.5 vo1%)-50% nitrous oxide-oxy-gen. The effects of benzodiazepine antaronist, flumazenil, were also examined. Lorazepam(0.5 mg/kg) administration did decrease mean arterial pressure(MAP) and herat rate(HR). It did significantly decrease cerebral blood flow(CBF)(measured by posterior sagittal sinus outflow method) by 25% of control value(68+/-l3 vs. 51+/-12ml/100gm/min, meanSD) and cereberal metabolic rate for oxygen(CMRO ) by 17% (3.96+/-1.04 vs. 3.30+/-0.92ml/l00gm/min, mean+/-SD). Electroencephalogram(EEG) converted to high amplitude, predominantly theta and delta activity. Intracranial pressure(ICP) increased markedly. Following flumazenil(0.06 mg/kg) administration, HR recovered completely to control level but MAP increased only at 5 min. compared to pre-flumazenil value and returned to pre-flumazenil level. CBF recovered to control level for 15 min. and deereased after 30 min. compared to control level but higher than pre-flumazenil level about 9-15%. CMRO recovered completely to control leveL EEG changed to an awake pattern after fluamzenil administration. It is concluded that lorarepam decreased cerebral function and metabolism and depressed hemodynamic fuction. Benzodiazepine antag- onist, flumazenil, was effective in reversing cerebral and hemodynamic effects, may be in dose related manner.
Anesthesia, General ; Animals ; Benzodiazepines ; Dogs* ; Electroencephalography ; Flumazenil* ; Hemodynamics ; Lorazepam* ; Metabolism

OBJECTIVES: The purpose of present study was to investigate the effect, safety and tolerability of risperdal sachet(oral solution) with lorazepam tablet versus intramuscular haloperidol and lorazepam injection for management of acute psychotic symptom in the elderly with organic mental disorder. METHODS: Total 37 patients who have dementia, medical or physical diseases, associated with acute psychotic symptom were randomly assigned to oral treatment with 1mg of risperdal sachet(oral solution) plus 1mg of lorazepam(N=17) or to intramuscular treatment with 2.5mg of haloperidol plus 2mg of lorazepam(N=20). The change of CGI scores was used for the evaluation of efficacy. RESULTS: Mean score improvements at 15, 30, 60, and 120 minutes after treatment were statistically significant at each time point in both groups(p<0.001) and were similar in both groups(p=0.189). CONCLUSION: A single oral dose of risperdal sachet(oral solution) plus lorazepam was as effective and tolerable as parenterally administered haloperidol plus lorazepam for the rapid control of acute psychotic symptom in the elderly with organic mental disorder.
Aged* ; Delirium ; Neurocognitive Disorders* ; Dementia ; Haloperidol* ; Humans ; Lorazepam*