In the Endoscopy Department of ENT National Institute from July 1999 to April 2003, 76 cases of fungal laryngititis were treated. Two isolated types of fungi were Aspergillus (73.63%) and Candida (22.36%) and the mixe of both two type (2.63). In 59 cases of Aspergillus infection, the treatment with itraconazole gave good results in 100%. Patients’ voice had totally recovered and fugal test showed negative results first before stopping treatment. The average duration of treatment lasts 6.27 weeks with no relapse after 6 months.
Therapeutics ; Laryngitis ; Aspergillus ; Itraconazole ; drugs

Acupuncture Therapy ; Adult ; Female ; Humans ; Laryngitis ; therapy

Child ; Humans ; Laryngitis ; therapy ; Nebulizers and Vaporizers

BACKGROUND AND OBJECTIVES: Although globus pharyngeus is a common disorder, the treatment is by and large unsatisfactory because of unreliable diagnosis. When we examine the larynx in patients with this disease, it is easy to observe variations in the structure of larynx, including the posterior laryngitis. Physicians regard these findings as normal variations, however, the hyperkinetic movement of supraglottis will show symptoms of globus pharyngeus. This study examined the outcomes of a voice therapy which induced laryngeal relaxation of the signs and symptoms of globus haryngeus. MATERIALS AND METHODS: While the control group was treated with antireflux therapy, the experimental group was treated with antireflux therapy as well as with voice therapy for laryngeal relaxation. The outcome showed resolution of the symptoms. RESULTS: The symptoms responded more greatly to the combined treatment than to the control group. Granularity in the vocal process and the hyperkinetic movement of supraglottis responded to the combined treatment. CONCLUSION: This study showed that voice therapy is one of the effective treatments for globus pharyngeus.
Diagnosis ; Humans ; Hyperkinesis ; Laryngitis ; Larynx ; Relaxation ; Voice*

Objectives: The purpose of this study was to determine the efficacy of proton pump inhibitor (PPI) therapy in treating the symptoms and laryngeal findings of laryngopharyngeal reflux (LPR). Methods: Placebo-controlled, randomized clinical trials published after June 2001 to January 2021 which used PPI as the sole intervention and the RSI or RFS as outcome measures were eligible for inclusion. Studies that were published prior to June 2001, those which only made use of questionnaires other than the RSI or RFS, those which used PPI in combination with other treatments, or those with unavailable full-text manuscripts were excluded. These studies were identified from MEDLINE, Scopus, Cochrane Library, Embase, and HERDIN Plus databases which were searched from May 21 to 26, 2020. The primary outcome was the mean difference between baseline/pre-treatment and post-treatment RSI scores for both PPI and placebo groups. The secondary outcome was the mean difference between pre-treatment and post-treatment RFS scores for PPI and placebo groups. Aggregate results of these outcomes were analyzed using forest plots. Heterogeneity was determined through prediction intervals. Risk of bias of individual studies was assessed using the Cochrane Collaboration’s Tool in Assessing Risk of Bias. Results: Nine randomized control trials were included with a total of 737 patients randomized and 595 patients analyzed – 294 from the PPI group and 301 from the placebo group. There were notable variations among the studies in terms of choice of PPI, dosage and frequency. Out of nine studies, four used both RSI and RFS in their analysis. Two studies used RSI alone and three used the RFS in combination with symptom questionnaires other than the RSI. There was a significant decrease in the RSI of the PPI group versus the placebo group with a mean difference of -2.83 (95% CI, -5.13 to -0.53, p = .02). However, there was no significant decrease in the RFS between PPI and placebo groups with a mean difference of -0.84 (95% CI, -2.66 to 0.98, p = .37). For two clinical trials which only reported post-treatment RFS, there was also no significant difference between the two treatment groups with a mean difference of 1.27 (95% CI, -0.22 to 2.76, p = .10). Conclusion This meta-analysis found that, although a statistically significant benefit in RSI was noted with PPI therapy, this difference may not translate to a clinically significant change in symptoms; therefore, there is insufficient evidence to recommend for or against the treatment of LPR with PPIs.
Laryngopharyngeal Reflux ; Proton Pump Inhibitors ; Laryngitis ; Hoarseness

BACKGROUND: Although influenza has been a leading cause of global morbidity and mortality, we have few data regarding the epidemiological and clinical characteristics of influenza activity in Korea. Since an outbreak of influenza was recognized during winter of 1996-1997, we analyzed the epidemiological and clinical features of influenza activity in the hospital setting. METHODS: All clinical specimens requested for isolation of influenza virus at Samsung Medical Center from October 1996 to April 1997 were included. Mardin- Darby canine kidney (MDCK) cell line was used for virus culture. Isolated viruses were confirmed with immunostain followed by subtyping. The demographic and clinical characteristics of the patients were reviewed retrospectively. RESULTS: Ninety-eight influenza viruses were isolated from 461 patients (21.3%). Influenza A and B virus was isolated from 58 (54 children and 4 adults) and 40 pediatric patients, respectively. One of 31 influenza A viruses were confirmed as A/Wuhan/359/95-like strain and 5 of 12 influenza B viruses were confirmed as B/Guangdong/8/97-like strains. Two distinctive peaks of influenza activity were recognized and the most common age of patients was less than 1 year for influenza A, and 3 to 5 years for influenza B. Common lower respiratory infections were pneumonia followed by croup, bronchiolitis and laryngitis. CONCLUSION: We analyzed the epidemiological and clinical features of influenza activity during winter of 1996-1997. Although this study was performed not in the community but in the hospital setting, the morbidity caused by influenza may not be low in Korea. Therefore, nationwide surveillance for influenza activity is warranted.
Bronchiolitis ; Cell Line ; Child ; Croup ; Epidemiology ; Herpesvirus 1, Cercopithecine ; Humans ; Influenza A virus ; Influenza B virus ; Influenza, Human* ; Kidney ; Korea ; Laryngitis ; Mortality ; Orthomyxoviridae ; Pneumonia ; Respiratory Tract Infections ; Retrospective Studies

Adult ; Female ; Fungi ; Humans ; Laryngitis ; microbiology ; Mycoses ; Vocal Cords ; microbiology

OBJECTIVETo observe clinical therapeutic effect of acupuncture kinetotherapy for acute simple laryngitis of wind-heat type and to probe the mechanism.

METHODSEighty cases were randomly divided into a test group and a control group, 40 cases in each group. The test group were treated with acupuncture kinetotherapy (Acupuncture was given at Kaiyin point No. 1 combined with deep respiratory movement of the glottis), once daily. The control group were treated with ultrasonic aerosol inhalation of 0.9% sodium chloride injection, gentamicin sulfate injection 80 000 U and Dexamethasone injection 5mg, twice a day. The treatment was given for 5 days for the 2 groups.

RESULTSThe cured and markedly effective rate was 90.0% in the test group and 82.5% in the control group with no significant difference between the two groups (P>0.05); in the test group there was a very significant difference before and after treatment in the cumulative score of symptoms and the acoustic parameters (P<0.01).

CONCLUSIONAcupuncture kinetotherapy has obvious therapeutic effect on acute simple laryngitis of wind heat type, with no toxic and adverse effects.

BACKGROUND AND OBJECTIVES: Laryngopharyngeal reflux (LPR), a most common cause of non-infectious laryngitis, occupies 20~30% of ENT outpatients, and over a half of patients who complains of voice disorder and laryngeal symptoms are associated with LPR. So we evaluate the usefulness of the esophagography as an initial screening test for patients suspected of LPR. SUBJECTIVES AND METHOD: From 2000 to 2002, we performed esophagography with water-siphon (WS) test for 540 patients with typical symptoms and telescopic findings. The results of esophagography were compared with those of 113 patients confirmed with gastroesohageal reflux (GER) and 174 patients without LPR or GER. The results of WS test were classified into normal, mild, moderate and severe according to the degree of reflux. RESULTS: In the WS test of LPR group, 48 patients were normal (8.9%), 166 mild (30.7%), 143 moderate (26.5%) and 183 severe degree of reflux (33.9%). We evaluated moderate and severe degree of reflux as having positive findings of the WS test because mild degree of reflux can be seen in physiologic conditions. In the LPR group, the positive ratio of WS test was 60.4%. In GER group, 12 patients were normal (10.6%), 30 mild (26.5%), 31 moderate (27.7%), 40 severe degree of reflux (35.4%) and 62.8% of positive WS test. In 174 patients without LPR or GER, 73 patients were normal (42.0%), 40 mild (23.0%), 17 moderate (9.8%) and 44 presented severe degree of reflux (25.2%). Fourty-two patients of the 540 LPR group (7.8%) showed esophageal lesions in esophagography. CONCLUSION: In literature, the sensitivity of esophagography is reported as 33%, but reflux provocation using the WS test increases the sensitivity over 60%. Also, esophagography can demonstrate esophageal abnormalities that might otherwise be missed. So we confirmed the effectiveness of esophagography as a strong initial screening test for LPR.
Humans ; Laryngitis ; Laryngopharyngeal Reflux ; Mass Screening* ; Outpatients ; Voice Disorders

BACKGROUND AND OBJECTIVES: The airway interruption method was developed as a combination of the measurement of expiratory pressure, mean air flow, intensity, and frequency. We evaluated the clinical usefulness of the airway interruption method in measuring vocal frequency, vocal intensity, mean air flow rate and expiratory air pressure. MATERIALS AND METHODS: We performed phonatory function tests in the patients with vocal nodule (n=380), vocal polyp (n=41), vocal sulcus (n=20), laryngitis (n=72), vocal paralysis (n=10) and glottic cancer, T 1 (n=5). And these results were compared with normal values which were reported previously. In 91 patients with vocal nodule and 5 patients with polyp, phonatory function test was followed up after laryngomicrosurgery and compared with preoperative test. RESULTS: In patients with vocal nodule and polyp, mean air flow rate was significantly increased (p<0.05). In polyp, these differences were greater than nodule group. In vocal paralysis, mean air flow rate was significantly increased than other groups. In glottic cancer (T1), expiratory air pressure was significantly increased than other groups. In laryngitis and sulcus vocalis, mean air flow rate was increased in some phonation methods. But their differences were less significant than other groups. After laryngomicrosurgery, mean air flow rate and expiratory air pressure were decreased in both groups. CONCLUSION: The aerodynamic test using the airway interruption method is a noninvasive, easy to perform and reliable for evaluation of aerodynamic conditions at the glottis. This research finds that the interruption method is effective both in evaluation of the treatment and in postoperative assessments of the laryngeal disorder patients.
Air Pressure ; Glottis ; Humans ; Laryngitis ; Paralysis ; Phonation ; Polyps ; Reference Values