1.Tocilizumab for refractory adult-onset still’s disease: Report of three cases
Francis Martin T. Cuenco ; Sandra V. Navarra
Philippine Journal of Internal Medicine 2020;58(4):158-160
OBJECTIVES:
To present three cases of adult-onset still’s disease (AOSD) who was initially refractory to corticosteroid therapy but were successfully treated with an interleukin-6 (IL-6) inhibitor, tocilizumab (TCZ).
BACKGROUND:
Adult-onset Still’s Disease (AOSD) is a systemic inflammatory disorder of unknown etiology characterized by quotidian fever, evanescent rash, and arthritis/arthralgia. The pro-inflammatory cytokine interleukin (IL) – 6 has been implicated in its pathogenesis.
CASE PRESENTATION:
Three patients (40F, 37F, and 27M) presented with quotidian fever, evanescent maculopapular rash, arthritis, anemia, leukocytosis, elevated acute phase reactants and hyperferritinemia of 3 to 4 months duration. All were diagnosed AOSD by Yamaguchi criteria after extensive work up to exclude other diagnostic possibilities. Each patient received high dose corticosteroids and 2 patients also received methotrexate (MTX) with initial improvement of symptoms. However, there was recurrence and exacerbation of clinical symptoms on tapering of steroid doses. Each patient was then given TCZ at 8 mg/kg. Within a month of the initial dose of TCZ, there was dramatic clinical and laboratory improvement, enabling rapid steroid dose tapering.
CONCLUSION
This series substantiates the role of IL-6 in the pathomechanisms of AOSD and demonstrates use of TCZ in the management of AOSD refractory to corticosteroids.
Interleukin-6
2.Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis.
Journal of the Korean Pediatric Society 1995;38(5):625-632
No abstract available.
Interleukin-6*
;
Meningitis, Aseptic*
3.A case of left atrial myxoma with increased interleukin-6.
Chan Soo MOON ; Jae Kyung CHOI ; Wook Sung CHUNG ; Kwang Mu YOON ; Ho Jung YOON ; Joon Chul PARK ; Jai Hyung KIM ; Koy Bo CHOI ; Soon Jo HONG ; Hyung Sik KANG ; In Pyo CHOI ; Kwang Ho PYUN
Korean Journal of Medicine 1993;45(4):533-537
No abstract available.
Interleukin-6*
;
Myxoma*
4.The Expression of Interleukin-6 in Chronic CCl4-induced Hepatotoxicity in Ethanol-fed Rabbits.
Sung Sook KIM ; Yeong Ju WOO ; Eun Hee HA ; Hee Jung SOHN ; Inpyoi CHOI
Korean Journal of Occupational and Environmental Medicine 1997;9(3):508-516
No abstract available.
Interleukin-6*
;
Rabbits*
5.The roles of interleukin-6 in fibrosis.
Hyung Sik KANG ; Inpyo CHOI ; Jeong Sang LEE ; Kwang Ho PYUN
Korean Journal of Immunology 1992;14(2):193-202
No abstract available.
Fibrosis*
;
Interleukin-6*
6.Interleukin-6 signaling in podocyte hypertrophy.
Kidney Research and Clinical Practice 2016;35(4):195-196
No abstract available.
Hypertrophy*
;
Interleukin-6*
;
Podocytes*
7.Modulation of graft-versus-host reaction, IL-6 production and lymphocyte proliforation by bestatin.
Tai You HA ; Jee Kyu KIM ; Young Min PARK ; Me Yae LEE ; Byong Suk PARK
Journal of the Korean Society for Microbiology 1991;26(1):87-104
No abstract available.
Interleukin-6*
;
Lymphocytes*
8.Effect of ethanol feeding on production of IL-2 and IL-6, and otherparameters of immunocompatency in rats.
Tai You HA ; Byung Sook PARK ; Hee Sung HWANG
Korean Journal of Immunology 1991;13(1):17-31
No abstract available.
Animals
;
Ethanol*
;
Interleukin-2*
;
Interleukin-6*
;
Rats*
9.Interleukin-6 and interleukin-10 in experimentally induced rat pulpal inflammation.
Seok Woo CHANG ; Seung Ho BAEK ; Chul Ho KIM ; Sung Sam LIM
Journal of Korean Academy of Conservative Dentistry 2002;27(3):232-238
No abstract available.
Animals
;
Inflammation
;
Interleukin-10
;
Interleukin-6
;
Rats
10.Skin Sclerosis with Elevation of Serum Interleukin-6 That Is Possibly Associated with Immunoglobulin 4-Related Disease.
Sei Ichiro MOTEGI ; Akihiko UCHIYAMA ; Kazuya YAMADA ; Akihito UEHARA ; Sayaka TOKI ; Osamu ISHIKAWA
Annals of Dermatology 2014;26(6):766-767
No abstract available.
Immunoglobulins*
;
Interleukin-6*
;
Sclerosis*
;
Skin*