No abstract available.
Immunosuppression*

No abstract available.
Humans ; Immunosuppression ; Mycobacterium chelonae*

No abstract available.
Immunosuppression* ; Prognosis* ; Transplantation*

No abstract available.
Immunosuppression* ; Liver Transplantation* ; Liver*

Multiple dermatofibromas are rare and their etiology is unknown. An association with immunosuppression or altered immunity including autoimmune disorders has been reported. The mechanism for the development of multiple eruptive dermatofibromas in the setting of immune disturbance remains unclear. We herein report four cases of multiple dermatofibromas, one of them is associated with immunosuppression.
Histiocytoma, Benign Fibrous* ; Immunosuppression

Infection-induced panniculitis develops either through direct inoculation or as a manifestation of sepsis. However, it has rarely been considered as a disease entity within broader context of panniculitis. Moreover, panniculitis associated with a cardiac abscess without the evidence of sepsis has not been reported. We describe a case of infection-induced panniculitis associated with a cardiac abscess. We suggest that infection should be considered as a potentially important etiology of panniculitis, especially in the case of immunosuppression, and in such a case, meticulous efforts should be done to find the focus of infection.
Abscess* ; Immunosuppression ; Panniculitis* ; Sepsis

Renal cell carcinoma in a renal allograft is a known but very rare occurrence. A 38 year old woman underwent renal transplantation with a kidney from a living related donor in 1985 and has had good renal graft function for the past 15 years. On routine follow-up, renal graft ultrasonography revealed a solid mass in the interior pole of the graft kidney. This finding was confirmed by computerized tomography (CT). Percutaneous needle biopsy of the renal mass revealed a renal cell carcinoma for which she underwent enucleation of the renal allograft tumor. This case represents the first reported occurrence of renal cell carcinoma in a renal allograft in the Philippines. (Author)
Kidney Transplantation, Immunosuppression

376 specimens consisting of 339 tumors and 37 alien tissues in the human host were studied with regards to the density of immunocellular infiltration (DI) at the tumor-stroma junction. The DI was read as 0,1,2,3,4, with 0 representing absence of the infiltrating immunocytes according to the authors proposed classificationThere was total disparity between the results of the control and that of the tumor group. Whereas the control group showed a 70.2% incidence, at DI 3 and 4 combined, the whole tumor group had only 18.1% and, therefore, a low immunocellular index (ICI) of 25.7% of the control (Group X). On the other hand, at DI 0 and 1, the tumor group had an incidence of 66.9%, while the control had only a 2.7% incidence at DI 1 and none at 0. It is striking that the high group incidences at DI 0 and 1 combined were sent in the invasive and metastic-embolic groups (73.7%) and 84.1%, respectively)The quantitative differences between the benign-preinvasive groups (A and B) and the invasive-metastatic groups (C and D) which have similar descending trends clearly point to their clearout behaviors, namely: the "host-dependent" and the "autonomous", respectively. The results of this study proved beyond doubt the immunosuppressive property of cancer. The experimental and clinical correlations with the above results were discussed. Mention was made also of the significance of the trophoblastic nature of cancer in relation to the authors findings. Fiscally, a hypothesis of "Cancer Rejection" was presented. and its various facets discussed. Preliminary clinical experimentation seems to support the hypothesis. These experiences may be the beginning of a relatively new challenge in oncotherapy. It can be said in closing that the various aspects of cancer immunology deserve an aggressive reappraisal, for this author is confident that in the not-too-distant future a much more simple, safe, and physiological method in the conquest of malignancy can become a living reality.(Summary)
Immunosuppression, Immunosuppressive Agents

Collapsing Glomerulopathy (CG) is a rare entity presenting as nephrotic syndrome and rapidly progressive renal deterioration. It has been first identified among African-American patients and subsequently dubbed HIV-associated nephropathy after a number of patients with HIV were found to have CG. It has re-emerged recently among patients with COVID-19. To our knowledge, this is the first case of primary collapsing glomerulopathy in the country to be published. The case is a 36-year-old Filipino female admitted due to bipedal edema which started 2 weeks post-partum. She has no comorbidities and social history was negative for illicit drug use. Initial work up showed hypoalbuminemia and diffuse hepatic disease on ultrasound. She was referred to a gastroenterologist where albumin infusion and paracentesis was done but with no improvement. She developed anasarca and was admitted. Paracentesis obtained minimal ascitic fluid. Serum ascites albumin gradient was low and baseline laboratories showed high creatinine, hypoalbuminemia, and albuminuria. 24-hour urine protein was 11 grams, ANA and anti-DsDNA were negative and c3 and c4 levels were normal. Hepatitis profile was negative for infection. Abdominal CT scan revealed multiple hypoenhancing lesions. Tumor markers CA-125, CA 19-9 and CA 15-3 were high. Breast ultrasound showed simple breast cyst. Gynecology consult was called where pap smear was negative for atypical cells. Surgery service recommended monitoring for the pancreatic and breast lesions. Kidney biopsy was delayed due to new onset bacterial pneumonia. COVID-19 RT-PCR test was negative. Patient was discharged improved with no edema. On follow up, the kidney biopsy result came out to be collapsing glomerulopathy. HIV test was then done and was negative. Bipedal edema and albuminuria recurred. She was started on tacrolimus. She has been on regular follow up and currently has no edema, no proteinuria and normal creatinine level. This is an interesting case as the primary glomerular disease has been masked by the earlier laboratory findings which led us to think of liver disease then a paraneoplastic nephrotic syndrome. Ultimately, the renal biopsy revealed the diagnosis. This serves as an index case for primary collapsing glomerulopathy in a Filipino patient on remission after being treated with tacrolimus.
Nephrotic Syndrome ; Immunosuppression Therapy

There were 39 aplastic anemia patients with immunopathology, who was treated by immunosuppresion such as: Spleenectomy, thymus transplantation using cyclosporine A. The results show that: immunosuppression has successful rate of 50-60% in aplastic anemia after internal treatment was not effectiveness.
Bone Marrow Diseases ; Immunosuppression ; Therapeutics