1.What is the best selection methods of medical freshmen and how to care the students after admission?.
Korean Journal of Medical Education 2013;25(3):185-187
No abstract available.
Humans
2.An Anatomical Study of the Human Caudate Lobe.
Baik Hwan CHO ; Hee Chul YU ; Zhe Wu JIN ; Eun Jeong JO
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2004;8(1):1-12
No abstract available.
Humans*
3.What Should Be Done to Increase Survival in Patients With Colorectal Cancer?.
Annals of Coloproctology 2013;29(4):135-135
No abstract available.
Humans
4.Polymerase Chain Reaction Analysis of Human Papillomavirus in Esophageal Squamous Cell Carcinoma with its Correlation to p53 mutation.
Wan Seop KIM ; Eun Kyung HONG ; In Kyu KIM ; Moon Hyang PARK ; Jung Dal LEE
Korean Journal of Pathology 1996;30(11):1018-1026
HPV infection has been implicated strongly in the pathogenesis of human squamous cell carcinoma(SCC). We analysed a series of 28 surgically removed, invasive squamous cell carcinoma of the esophagus by polymerase chain reaction to detect HPV DNA using consensus primers and 8 type-specific primers of HPV (6, 11, 16, 18, 31, 33, 35, 51). HPV 6, 31, 35 or 51 DNA were detected in 20 out of 28 cases (71.4%) of the esophageal SCCs. HPV 51 was the most frequently detected type, occuring in 13 out of 28 cases (46.4%). p53 immunohistochemical staining was also performed to demonstrate any relationship to HPV DNA positivity. It showed positivity in 16 out of 28(57.1%) esophageal SCCs, and HPV DNA and p53 positivity were concurrently detected in 11 out of 28 cases of SCCs. There was no significant inverse relation between HPV DNA positivity and p53 expression(p>0.05). Our results supported HPV involvement in esophageal squamous cell carcinoma, and suggested there may be another pathway not related to the p53-binding pathway in the carcinogenesis of esophageal SCCs by HPV.
Humans
5.The Effects of Nicotine and NNK on gingival fibroblast.
Chi Hoon HWANG ; Mi Young PARK ; Kwang Kyun PARK ; Seong Ho CHOI ; Kyoo Sung CHO ; Chong Kwan KIM ; Jung Kiu CHAI
The Journal of the Korean Academy of Periodontology 1998;28(4):703-719
In order to observe the effects of Nicotine and NNK on cultured human gingival fibroblast, several factors were examined including mutagenicity, the number of cells attached culture plate surface through MTT test, the abundance of collagen & collagenase in mRNA level and collagenolytic activity in extracellular matrix. The results were as follows; 1. Regardless of the co-existence of S9, Nicotine did not show the mutagenicity by itself and NNK by itself showd the same result; However, dose related mutagenicity was shown in NNK with S9. 2. The number of fibroblasts attached cultured plate surface was measured by MTT procedure. The number of cells in Non-smokers increased at all time periods as compared to those of smoker. 3. Non-smoker's fibroblast treated by NNK or Nicotine was dose-dependently decreased in the number of cells when compared to untreated control. In higher dose, Nicotine showed the cellular toxicity , but NNK did not. 4. No change in the abundance of mRNA for proalpha1 and proalpha2 was shown in Nicotine treated group but in gingival fibroblasts following treatment with NNK, the abundance of mRNA for proalpha1, but not proalpha2 collagen was decreased. 5. The abundance of mRNA for collagenase was decreased when NNK was treated but no change occurred in Nicotine treated group. 6. The effect of NNK and Nicotine in collagenolytic activity showed that ,collagenase activity exclusively react to type I collagen, was increased in both group, but gelatinase exclusively react to type IV collagen was not influenced at all. Collagenase activity of smoker's fibroblast was also increased as much as Nicotine and NNK group. The findings suggest that both of Nicotine and NNK lead gingival fibroblast to decrease in the abundance of collagen. And it seems to be that Nicotine and NNK have independent pathway toward the gingival fibroblast.
Humans
6.Atypical Fibroxanthoma in a 115-Year-Old Patient.
Fethiye Berna GOKTAS ; Hande AKDENIZ ; Kadri OZER ; Hatice UNVERDI ; Ugur KOCER
Archives of Plastic Surgery 2015;42(6):803-805
No abstract available.
Humans
7.Overexpression of Mutant p53 in Human Anaplastic Astrocytoma and Glioblastoma Multiforme.
Sang Sook LEE ; Kam Rae CHO ; Cheoul Hee YUN ; Sang Pyo KIM ; Kwan Kyu PARK ; Eun Sook CHANG ; Eun Ik SOHN
Korean Journal of Pathology 1994;28(4):376-380
A total of 30 cases of cerebral gliomas, including 6 cases of low grade astrocytomas, 6 anaplasticastrocytoomas and l8 glioblastomas multiforme, was examined immunohistochemically to demonstrate the overexpression of mutant forms of p53 protein and to evaluate their relationships with histological subtypes. A p53 monoclonal antibody was applied to the routine formalin fixed, paraffin-embedded tissues for this study using microwave-assisted avidin-biotin method. Overexpression of p53 protein was identified in 4 out of 6 anaplastic astrocytomas (66.7%) and in l3 out of l8 glioblastomas multiforme (72.2%). No immunohistochemical positivity of p53 was found in adjacent normal brain tissue, gliosis and 6 cases of astrocytoma. These results suggest that overexpression of mutant p53 may be an important step in the development and progression of malignant astrocytoma, especially of the aggressive subtypes of glioma, including glioblastoma multiforme.
Humans
8.Changes in Ocular Excyclotorsion According to Graded Inferior Oblique Recession.
Donghun LEE ; Won Jae KIM ; Myung Mi KIM
Journal of the Korean Ophthalmological Society 2016;57(8):1268-1273
PURPOSE: To investigate changes in ocular excyclotorsion in patients with inferior oblique overaction (IOOA) according to amount of correction by graded inferior oblique recession and to compare the amount of excyclotorsion between primary IOOA and secondary IOOA. METHODS: This study included 54 eyes of 54 patients who were diagnosed with unilateral IOOA and underwent graded inferior oblique recession. Fundus photographs were taken pre- and postoperatively. The sum of angles of torsion of both eyes was used to analyze changes in excyclotorsion. The angle of excyclotorsion was analyzed using the ImageJ program. RESULTS: Eighteen eyes were grade 2, 24 eyes were grade 3 and 12 eyes were grade 4. Preoperative angle of excyclotorsion was 16.23 ± 5.96° for the patients with grade 2 eyes, 18.83 ± 5.76° for the patients with grade 3 eyes and 29.00 ± 10.23° for the patients with grade 4 eyes. Therefore, as the degree of IOOA increased, the amount of excyclotorsion became larger. There was no statistical significance between grade 2 and grade 3 (p = 0.467), however, there was a statistically significant difference between grade 3 and grade 4 (p < 0.001). Postoperative angle of excyclotorsion was significantly decreased in each group (grade 2: p = 0.020, grade 3: p < 0.001, grade 4: p = 0.041). The amount of surgical recession of inferior oblique muscle showed a positive correlation with a decrease in the angle of excyclotorsion, but was not statistically significant. The amount of excyclotorsion and the decrease of excyclotorsion after surgery were larger in secondary IOOA than in primary IOOA, but were not statistically significant (p = 0.260). CONCLUSIONS: As the preoperative degree of IOOA increased, the amount of correction of excyclotorsion became larger but there is no statistical significance. Correction of IOOA and excylclotorsion is expected after graded inferior oblique recession.
Humans
9.An Approach to Febrile Patients.
June Myung KIM ; Young Goo SONG
Journal of the Korean Medical Association 1998;41(1):49-55
No abstract available.
Humans
10.English Journal: the Destination of Korean Journal of Family Medicine?.
Korean Journal of Family Medicine 2009;30(5):378-378
No abstract available.
Humans