No abstract available.
Curcumin*

No abstract available.
Curcumin

No abstract available.
Curcumin ; Pain Management

Study results showed that Rhizomes of Curcuma longga containted flavonoid, curcumine, anthraglycoside, alkaloide... Curcumine were extracted and isolated from the rhizome (dry material) of Curcuma longa with ethanol (0.80%) and with methanol (1,02%). Curcumine and extract of Rhizoma Curcumae longae treated on 10 strains of bacteria and Candida albicans invitro. The results showed that they have strong antibacterial and antifungal activity
Chemistry ; Curcumin ; Divorce

To use HPLC for claborating method of quantifying curcumine in tablet and ointment containing gingiber rhizoma product. Curcumine in domeric tablet and curcumin ointment were quantified by HPLC. In the study schema: establising titration cure, extracting curcumine from samples; evaluating value of the method, accuracy and precision in the analysis on curcumine tablet, the method had got: the precition get to 0,893% accuracy 96,98%, lineal interval 0,1mg/l – 100mg/l; in ointment, precision 1,28%, accuracy 92,42%
Curcumin ; Pharmaceutical Preparations ; Tablets ; Crocus

Studied subjects: dried extract of Asiatic Pennywort Herb - Tumeric, 1kg dried extracts is equivalent 42.5kg fresh materia medica (25kg Centella asiatica and 17.5kg Curcuma longa); The compared compositions contained: content of curcumin 95%, content of asiaticosid 90%. The study provided quality specifications as follows: appearance, loss on drying, the solubility in water and in alcohol, the water-insoluble teside, heavy metals limit, pH, ash, fungus, mould, and microbial limit; phosphorus pesticide residues, qualitative and quantitative determination of triterpene ester glycosides and curcuminoids
Pharmaceutical Preparations ; Curcumin ; Materia Medica

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.
Absorption* ; Biological Availability* ; Curcuma ; Curcumin* ; Metabolism* ; Spices*

No abstract available.
Animals ; Curcumin* ; Hyperalgesia* ; Ligation* ; Rats* ; Spinal Nerves*

Curcumin is exclusively isolated from Zingiberaceae plants with a broad spectrum of bioactivities. In the present study, we used the diketide-CoA synthase (DCS) and curcumin synthase (CURS) genes to construct a non-natural fusion gene encoding diketide-CoA synthase::curcumin synthase (DCS::CURS). This fusion protein, together with the acetyl coenzyme A carboxylase (ACC) and the 4-coumarate coenzyme A ligase (4CL), were introduced into Escherichia coli for the production of curcumin from ferulic acid. The process is divided into two stages, the growth stage using LB medium and the fermentation stage using the modified M9 medium. The yield of curcumin reached 386.8 mg/L by optimizing the induction of protein expression in the growth stage, and optimizing the inoculum volume, medium composition and fermentation time in the fermentation stage, as well as the addition of macroporous resin AB-8 into the second medium to attenuate the toxicity of the end product. The exploitation of the non-natural fusion protein DCS::CURS for the production of curcumin provides a new alternative to further promoting the production of curcumin and the related analogues.
Curcumin/pharmacology* ; Escherichia coli/genetics* ; Fermentation

Aims: Infectious bronchitis virus (IBV) is a highly contagious, acute viral respiratory disease that mostly affects chickens. The poultry sector has suffered enormous losses as a result of IBV. Currently, live attenuated vaccines are routinely used to prevent and control IBV. However, due to the enormous genetic variety, vaccinations are becoming ineffective, with low cross-protection effects among vaccine serotypes. The present study aimed at investigating the possible antiviral effects of curcumin, epigallocatechin gallate (EGCG) and their mixtures against IBV in vivo. Methodology and results: Curcumin, EGCG and their combinations were administered to infected and uninfected chicken groups and viral load titers were determined by real-time PCR. The clinical symptoms of both the negative and positive control groups were also compared. Finally, the trachea tissues of each group were examined histopathologically. According to our findings, the viral titer and the clinical signs dropped significantly during the pretreatment infection procedure. Curcumin, EGCG and their combinations also show significant antiviral activities. Conclusion, significance and impact of study This study clearly shown that natural compounds and their combinations, such as curcumin or/and ECGC can reduce viral pathogenicity in vivo, suggesting that they might have therapeutic implications in the poultry sector.
Infectious bronchitis virus--physiology ; Curcumin ; Catechin