No abstract available.
Contraception, Postcoital* ; Emergencies*

No abstract available.
Contraception, Postcoital* ; Emergencies*

No abstract available.
Contraception*

No abstract available.
Contraception*

No abstract available.
Contraception*

Intrauterine device (IUD) is a safe and efficient method of contraception in comparison with the efficacy of tubal sterilization, yet remains underutilized due to biased or outdated information about IUD. It is currently believed that the mechanism of action for IUDs is the production of an intrauterine environment that is spermicidal. IUD does not increase a woman's risk for pelvic infection, ectopic pregnancy, or subsequent infertility. IUD insertion in nulliparous or unmarried women is not contra-indicated. IUD is also a useful contraceptive method for those women without increasing the risk of ascending pelvic infection. The other benefit of IUD beyond contraception includes lowering the risk of endometrial cancer. The levonorgestrel-releasing intrauterine system reduces massive menstrual bleeding and dysmenorrhea. The copper IUD is the most effective method for emergency contraception. The careful patient selection and pre-insertion counseling are crucial to the success of IUD.
Bias (Epidemiology) ; Contraception ; Contraception, Postcoital ; Copper ; Counseling ; Dysmenorrhea ; Endometrial Neoplasms ; Female ; Hemorrhage ; Humans ; Infertility ; Intrauterine Devices ; Levonorgestrel ; Patient Selection ; Pelvic Infection ; Pregnancy ; Pregnancy, Ectopic ; Single Person ; Sterilization, Tubal

OBJECTIVE: To assess the effectiveness of emergency single-dose levonorgestrel contraception in preventing unintended pregnancies among woman who visited the emergency department (ED) due to sexual assault (SA). METHODS: We conducted a retrospective chart review in a university hospital in South Korea. Cases from November 10, 2006 to November 9, 2009 were enrolled. Information from the initial visit to the ED and subsequent follow-up visits to the gynecology outpatient clinic was collected. RESULTS: In total, 1,179 women visited the ED due to SA. Among them, 416 patients had a gynecological examination and 302 patients who received emergency contraception (EC) (1.5 mg single-dose levonorgestrel) at the ED due to SA were enrolled. Ten patients did not return for follow-up examinations. In follow-up visits at the outpatient clinic, two pregnancies were confirmed, which showed the failure rate of the EC to be 0.68%. CONCLUSION: Single-dose levonorgestrel EC is extremely effective at preventing pregnancy among victims of SA.
Ambulatory Care Facilities ; Contraception ; Contraception, Postcoital ; Emergencies ; Female ; Follow-Up Studies ; Gynecological Examination ; Gynecology ; Humans ; Levonorgestrel ; Pregnancy ; Republic of Korea ; Retrospective Studies

Sperm protein 17 (Sp17) is a testis-specific protein involved in acrosome reaction in spermatozoa. However, the Sp17 gene has been recently detected in normal non-testis tissues and malignant neoplasias. Therefore Sp17 may be a potential target for immunocontraception and a suitable target for tumor immunotherapy. This paper reviews the advances in the protein characterization, expression and distribution, and biological function of Sp17 and its clinical research.
Animals ; Antigens, Surface ; Carrier Proteins ; analysis ; physiology ; Contraception, Immunologic ; Humans ; Immunotherapy ; Male

The ideal goal of male immunocontraception is to develop a safe, effective, convenient, acceptable and reversible contraceptive vaccine. Current studies mainly focus on screening the most suitable target antigens from reproductive hormones and sperm functional proteins for the development of immuno contraceptive vaccines. The vaccine targeting reproductive hormones has not been widely used due to its different degrees of side effects and complicated operation. Recent studies show the practicability and applicability of the immuno contraceptive vaccine targeting sperm specific antigens, but its development is confronted with many challenges, such as how to select appropriate target antigens, how to enhance the immunogenicity of the vaccine, how to choose appropriate drug-delivery ways, how to reduce its side effects, and how to decrease its cost.
Antigens ; immunology ; Contraception, Immunologic ; methods ; Contraceptive Agents, Male ; immunology ; Humans ; Male ; Vaccines ; immunology

The epididymal protease inhibitor (Eppin) has recently been cloned in human and mice, which is specifically expressed in the epididymis and testis. Eppin is a cystine-rich secretory protein which contains signal peptide, WAP and BPTI motifs. Eppin is involved in sperm maturation and fertilization, and in the innate immune system of human epididymis. Immunocontraception with Eppin is effective and reliable, but its safety is to be further proved. This paper summarizes the effects of Eppin of fertilization and immunity, as well as its utilization in immunocontraception.
Animals ; Contraception, Immunologic ; Epididymis ; immunology ; Fertility ; physiology ; Haplorhini ; Male ; Mice ; Proteins ; immunology ; physiology ; Spermatozoa ; physiology