A cobalt nanoparticles modified ITO electrode (NpCo/ITO) was prepared by casting cobalt nanoparticles onto ITO electrode and the cobalt nanoparticles were synthesized by NaHB4 reduction. The electrochemical behaviors of adriamycin (ADM) on NpCo/ITO were studied. The modified ITO electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In a 0.01 mol L(-1) PBS (pH 8.0) buffer solution, a sensitive reduction peak of ADM was obtained. A linear relationship is held between the peak current and ADM concentration in the range of 1.0 x 10(-8) - 2.0 x 10(-6) mol L(-1) with detection of 5.0 x 10(-9) mol L(-1)- by cyclic voltammetry (CV) response. The reduction process was irreversible with adsorption at the NpCo/ITO electrode. The modified electrode showed an excellent electrocatalytic activity for the ADM electrochemical reduction.
Antineoplastic Agents ; chemistry ; pharmacology ; Clinical Laboratory Techniques ; Cobalt ; chemistry ; Doxorubicin ; chemistry ; pharmacology ; Electrochemistry ; Electrodes ; trends ; Nanoparticles ; chemistry

Crystallization ; methods ; Crystallography, X-Ray ; methods ; Drug Design ; Drug Evaluation, Preclinical ; methods ; Pharmaceutical Preparations ; chemistry ; Salts ; chemistry

No abstract available.
Chemistry, Clinical*

Gardeniae Fructus contains volatile ingredients, however, the species and proportions in different processed products of Gardeniae Fructus are different. In this experiment, volatile ingredients were separated by steam distillation with content of 1.2, 1.0, 0.9, 0.7 µL · g(-1) in Gardeniae Fructus, fried Gardeniae Fructus, stir-baked Gardeniae Fructus, Gardeniae Fructus fried into carbon respectively. One hundred and twenty-four kinds of volatile components were identified by GC-MS. Fifty-three kinds of volatile ingredients consisted in Gardeniae Fructus accounting for 93.85%, 54 kinds in fried Cardeniae Fructus accounting for 92.01%, 32 kinds in stir-baked Cardeniae Fructus accounting for 91.59% and 43 kinds in Gardeniae Fructus fried into carbon accounting for 90.81%. In this paper, analysis of Gardeniae Fructus by GC-MS provides a scientific basis for elucidating the mechanism of different processed products.
Chemistry, Pharmaceutical ; Drugs, Chinese Herbal ; chemistry ; Gardenia ; chemistry ; Gas Chromatography-Mass Spectrometry ; Molecular Structure ; Volatile Organic Compounds ; chemistry

Is it necessary to open the course "general chemistry" to help freshperson to complete courses of organic chemistry and physical chemistry in the preliminary course of College of Medicine, Hallym University? As a basic step to answer this question, the records of the organic chemistry and physical chemistry were compared according to "chemistry" selection at the College Scholastic Ability Test in the freshperson of College of Medicine, Hallym University in the year 2000. There was a significant difference of the records of organic chemistry between chemistry selecting group and chemistry non-selecting group that selected physics, biology and earth science. There was a no significant difference between chemistry selecting female and non-selecting female, although there was a significant difference between chemistry selecting male and non-selecting female. As for physical chemistry, the records of selecting chemistry group were higher than those of the non-selecting group. There was a significant difference between non-chemistry selecting male and chemistry selecting male and female while a no significant difference between non-chemistry selecting male and non-chemistry selecting female. However, records of non-chemistry selecting female showed no significant difference with chemistry selecting male and female. This result means that difference of records is not dependent on the chemistry selecting but dependent on the sexual difference. Therefore, the opening of "general chemistry" as preliminary course for organic chemistry and physical chemistry cannot be essential. The attitude on the learning and incentive might be more important factors for the completion of the courses of organic chemistry and physical chemistry.
Biology ; Chemistry* ; Chemistry, Organic* ; Chemistry, Physical* ; Curriculum ; Earth Sciences ; Female ; Humans ; Learning ; Male ; Motivation

Two phenolic compounds were isolated from the aerial part of Excoecaria cochinchinensis Lour. for the first time, and were determined by means of nuclear magnetic resonance and gas chromatography-mass spectrometry as 3,4,5-trihydroxy-benzoic acid (gallic acid) and its ethyl benzoat derivative: 3,4,5-trihydroxy-ethyl benzoat
chemistry ; Biochemistry ; Chemistry, Physical ; Hydroxybenzoic Acids

Optically active form of alpha-cyano-3-phenoxybenzyl (CPB) alcohol, building block of pyrethroid insecticides, was synthesized as its acetate by the combination of anion-exchange resin (D301)-catalyzed transcyanation between m-phenoxybenzaldehyde (m-PBA) and acetone cyanohydrin (AC), and lipase (from Alcaligenes sp.)-catalyzed enantioselective transesterification of the resulting cyanohydrin with vinyl acetate. Through optimizing technological conditions, the catalyzing efficiency was improved considerably compared to methods previously reported. Concentrations of CPB acetate were determined by gas chromatograph. The enantio excess (e.e.) values of CPB acetate were measured by NMR (nuclear magnetic resonance) method. Effects of solvents and temperatures on this reaction were studied. Cyclohexane was shown to be the best solvent among the three tested solvents. 55 degrees C was the optimal temperature for higher degree of conversion. External diffusion limitation was excluded by raising the rotational speed to 220 r/min. However, internal diffusion could not be ignored, since the catalyst (lipase) was an immobilized enzyme and its particle dimension was not made small enough. The reaction rate was substantially accelerated when the reactant (m-PBA) concentration was as high as 249 mmol/L, but decreased when the initial concentration of m-PBA reached to 277 mmol/L. It was also found that the catalyzing capability of recovered lipase was high enough to use several batches. Study of the mole ratio of AC to m-PBA showed that 2:1 was the best choice. The strategy of adding base catalyst D301 was found to be an important factor in improving the degree of conversion of the reaction from 20% to 80%. The highest degree of conversion of the reaction has reached up to 80%.
Alcaligenes ; enzymology ; Benzaldehydes ; chemistry ; Combinatorial Chemistry Techniques ; methods ; Lipase ; chemistry ; Nitriles ; chemistry ; Organic Chemicals ; chemistry ; Phenyl Ethers ; chemical synthesis ; Technology, Pharmaceutical ; methods

No abstract available.
Chemistry, Clinical ; Clinical Chemistry Tests ; Methods

The effective analysis of the stupefacient must be a sensitivity, specificity, and reliability, correct, prompt and easy to make. There are 2 kinds of stupefacient including natural and synthetic agents. The metabolism of the stupefacient and the collection of samples influenced on the results of analysis. The tests of the stupefacient are a test with the high sensitivity in the ligal aspect
Clinical Chemistry Tests

AIMTo investigate the lattice mechanisms involved in the increased dissolution effect of polyethylene glycol (PEG 6,000) dispersion system on poorly soluble drug silymarin (SILY).

METHODSFusion method was used to prepare the solid dispersions of SILY with PEG 6,000. Evaluation of the improvement of dissolution was performed with dissolution studies in vitro. X-ray powder diffraction combined with diffraction peak pattern-fitting procedure were applied to quantitatively analyze the changes of lattice parameters. The interaction of SILY and PEG 6,000 was also determined with Fourier transform-infrared (FT-IR) spectroscopy.

RESULTSThe dissolution rate of SILY was considerably increased when formulated in solid dispersion of PEG 6,000 as compared to pure SILY. The datum from the X-ray diffraction showed the changes in the lattic spacings and particular diffraction peaks (position and the intensity) of PEG 6,000 and SILY. These could explain the increased rate of SILY released from solid dispersion system. The information of FT-IR spectroscopy showed the absence of well-defined drug-polymer interaction.

CONCLUSIONThe dissolution improvement of poorly soluble SILY from solid dispersion of PEG 6,000 can be illuminated by the changes of the lattice parameters of PEG 6,000 and the drug.

Chemistry, Pharmaceutical ; Crystallization ; Crystallography, X-Ray ; Drug Carriers ; Polyethylene Glycols ; chemistry ; Silymarin ; administration & dosage ; chemistry ; Solubility