A study of 60 cases of obstructive jaundice revealed the following: (1) Abdominal pain is a very frequent symptom(2) The incidence of pruritus was rather low(3) The most common cause of obstructive jaundice is common bileduct stone(4) Bilirubin I was elevated in the majority of cases. Bilirubin II and icterus index were elevated in all(5) There was no change in the color of the stool in most at the cases. (Summary)
Bilirubin

1. Seven cases with massive gastric hemorrhage resulting in profuse hematemesis form the basis of this report. Four of these were admitted in the Medical Wards of the Philippine General Hospital, two were patients admitted in the Pay Section of the same Hospital, and the sixth was an American internee admitted in a special ward for internees of the same hospital2. Four of these patients died, and a complete pathologic report for each was available. Two were operated on and accurate operative findings were also available for these patients. One had no operative or autopsy verification of the clinical impression. But this appears well supported by clinical laboratory and X-ray findings3. Four of these patients were found suffering from peptic ulcer and the other three from portal chirrhosis. The patients with peptic ulcer showed practically no bilirubin in the blood (Whether B-I or B-II) while those with portal cirrhosis showed significant amounts of B-I4. When clinical, laboratory , or x-ray findings are not sufficiently distinct for the differentiation of these two conditions in cases of massive gastric hemorrhage, the bilirubin (B-I) content of the blood may help in the differentiation. Peptic ulcer is not accompanied by B-I in the blood, while portal cirrhosis is always accompanied by functional disturbances of the liver. This is shown by the constant presence of B-I in the blood. (Conclusion)
Blood, Bilirubin

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.
Bilirubin ; Biliverdine ; Carbon Monoxide ; Ferritins ; Heme ; Heme Oxygenase (Decyclizing) ; Heme Oxygenase-1 ; Inflammation ; Iron

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.
Bilirubin ; Biliverdine ; Carbon Monoxide ; Ferritins ; Heme ; Heme Oxygenase (Decyclizing) ; Heme Oxygenase-1 ; Inflammation ; Iron

No abstract available.
Bilirubin* ; Humans ; Infant, Newborn*

No abstract available.
Bilirubin* ; Humans ; Infant, Newborn*

No abstract available.
Bilirubin* ; Humans ; Infant, Newborn*

No abstract available.
Bilirubin ; Carotid Artery Diseases

No abstract available.
Bilirubin ; Carotid Artery Diseases

Serum creatinine has been widely used clinically as an important index for kidney function. Kinetic Jaffe assay is used for serum creatinine analysis at about 80% of clinical laboratories in Korea. There are two major interferences when creatinine level is measured by kinetic Jaffe method. One is Jaffelike chromogen, which causes positive interference, and the other is bilirubin that creates negative interference. Positive interference created by Jaffelike chromogen can be easily corrected by subtracting 0.3 mg/dL (arithmetic compensation), which is average interference by Jaffelike chromogen in normal serum, from the measured creatinine value by kinetic Jaffe method. The interference created by bilirubin can be eliminated by rate blanking which corrects the rate of change in absorbance by bilirubin from the absorbance change by Jaffe reaction. Compensated rate-blanked Jaffe kinetic assay employs above two major corrections. In clinical laboratories currently using kinetic Jaffe Method, simple application of "compensated rate-blanked Jaffe kinetic assay" can determine serum creatinine values that minimizing major interferences without change of reagent.
Bilirubin ; Creatinine ; Kidney ; Korea