2.The effect of ritodrine, aminophylline and their combination upon the spontaneous contractitility of nonpregnant human uterus.
Jong Kun LEE ; Ki Sung RYU ; Jang Heub KIM ; Ku Taek HAN ; Jin Hong KIM ; Jong Gu RHA ; Soo Pyung KIM ; Hun Young LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):1828-1834
No abstract available.
Aminophylline*
;
Humans*
;
Ritodrine*
;
Uterus*
3.The effects of aminophylline on the superoxide anion generation of neutrophils from established human sepsis caused by acute pneumonia.
Yong Hoon KIM ; Jun Young PARK ; Mi Kyong CHA ; Sang Moo LEE ; Hyeon Tae KIM ; Soo Taek UH ; Yeon Tae CHUNG ; Choon Sik PARK
Tuberculosis and Respiratory Diseases 1993;40(1):16-22
No abstract available.
Aminophylline*
;
Humans*
;
Neutrophils*
;
Pneumonia*
;
Sepsis*
;
Superoxides*
4.Comparative potency of some official gastro-intestinal antispasmodics as studied in experimental animals.
VALDEZ EV ; PORTES JC JR ; DE LEON GV ; ROMAN LR ; ESTRADA HR
Acta Medica Philippina 0000;():0-
1. The antispasmodic effect of some official drugs were studied in dogs using balloons appropriately placed on the intact enteric tract. Intestinal contractions were kymographically recorded2. Comparable doses (threshold relaxing doses) of the pharmacologic agents were determined and tested under uniform experimental conditions3. Tested against spontaneous, Barium-stimulated and Pilocarpine-stimulated intestinal contractions, Methantheline and Atropine were shown to be the most potent agents. Aminophylline, Papaverine and Glyceryl trinitrate follow in the order named. This comparison is on the basis of the average duration of their respective inhibiting effect on the intestine4. The experimental findings in this method of study appear to be in close agreement with clinical observations5. It is postulated that in certain gastro-intestinal conditions characterized by hyperperistalsis, spasm and pain, these antispasmodics will prove clinically effective, if wisely administered. (Summary and Conclusions)
Parasympatholytics, Atropine, Methantheline, Aminophylline, Glyceryl Trinitrate, Barium, Pilocarpine, Antispasmodics
5.Study on evaluation index of acupoint transdermal administration--drug delivery coefficient.
Jian-ping LIU ; Jia-bi ZHU ; Sheng-jun CHEN ; Xin ZHAO
Chinese Acupuncture & Moxibustion 2006;26(7):507-509
OBJECTIVETo investigate the correlation of skin electric resistance changes with the blood drug content in acupoint transdermal administration, and to establish an new evaluation index for drug delivery efficiency through acupoints.
METHODSTwenty-four rabbits were randomly divided into an observation group and a control group. In the observation group, aminophylline was administrated through "Feishu" (BL 13), "Geshu" (BL 17) and "Danzhong" (CV 17) which are commonly used for treatment of bronchial asthma, and the control group through sham-points on the back. The skin resistance and plasma aminophylline content were determined after application of aminophylline to the points, and their changes with time were observed. The ratio of Css/Rss at stability was defined as delivery coefficient (DC) which reflects the efficiency of delivering drug at acupoints and sham acupoints.
RESULTSBoth the plasma aminophylline and the skin resistance value tended to steady about 6-8 h after application of aminophyiophylline. The DC in the acupoints was higher than that in the sham-acupoints (P < 0.01). And there was significant difference as DC of the "Feishu"was significant difference (BL 13) and "Danzhongas DC of the "Feish" (BLCV 17) compared with that of "Geshu" (BL 17) (P < 0.01).
CONCLUSIONThe bigger the DC is, the higher the efficiency of drug delivery is; the efficiency of drug delivery through acupoints is higher than that through sham-acupoints.
Acupuncture Points ; Administration, Cutaneous ; Aminophylline ; administration & dosage ; pharmacokinetics ; Animals ; Electric Impedance ; Female ; Male ; Rabbits
6.Investigation of pharmacokinetics and pharmacodynamics of different doses of aminophylline in very low birth weight infants.
Xiao-Yan YANG ; Jing ZHAO ; Jing SHI ; Jin-Lin WU ; Da-Peng CHEN ; Jun TANG ; Ying XIONG ; De-Zhi MU
Chinese Journal of Contemporary Pediatrics 2015;17(11):1171-1175
OBJECTIVETo study the pharmacokinetic and pharmacodynamic features of different doses of aminophylline in very low birth weight (VLBW) infants with different postmenstrual ages, weights, and ages (in days).
METHODSA total of 40 VLBW infants with apnea were enrolled. After an intravenous loading dose of 5 mg/kg aminophylline, they were randomized into two groups with different maintenance doses of aminophylline (1 mg/kg and 2 mg/kg, once every 8 hours). Blood concentrations of aminophylline and liver and renal functions were monitored at 8 hours, 3 days, and 7 days after the loading dose. Attacks of apnea were documented. Pharmacokinetic data of aminophylline were compared between the two groups.
RESULTSThe steady-state plasma concentration of aminophylline and plasma clearance in the 2 mg/kg group were significantly higher than those in the 1 mg/kg group (P<0.05). However, the elimination half life was shorter in the 2 mg/kg group (P<0.05). Days of apnea attacks within 7 days after birth in the 2 mg/kg group were significantly fewer than in the 1 mg/kg group (P<0.05). Aminophylline plasma clearance was positively correlated with age (in days) after birth and postmenstrual age in both groups.
CONCLUSIONSIn VLBW infants, pharmacokinetics and pharmacodynamics are different when different maintenance doses of aminophylline are given. The maintenance dose of 2 mg/kg is associated with a better effect in the treatment of apnea. Postmenstrual age and age (in days) should be considered during the adjustment of dose, and routine blood concentration monitoring should be performed.
Aminophylline ; pharmacokinetics ; pharmacology ; Apnea ; drug therapy ; Female ; Humans ; Infant, Newborn ; Infant, Very Low Birth Weight ; Male
7.A Case Report of Asthmatic Attack after Supraclavicular Block.
Sang Bong LEE ; Hye Won LEE ; Hae Ja LIM ; Byoung Kuk CHAE ; Jung Soon SHIN ; Seong Ho CHANG
Korean Journal of Anesthesiology 1993;26(2):347-349
In recent years, it has been common to use bupivacaine for prolonged operation because of its long duration of action but, besides of this benefits, we always are cautious of using bupivacaine for its possible systemic, toxicity, such as convulsion, myocardial depression. We experienced a case of asthmatic attack right after injection of 0.5% bupivacaine 125 mg for BPB(brachial plexus block) in a 26 year old male patient with chronic renal failure for the revision of a-v fistula. With the administration of aminophylline and oxygen by mask the patient was anounced about delaying operation and the symptoms were gone. Next day with local infiltration of 2% lidocaine operation was done uneventfully.
Adult
;
Aminophylline
;
Bupivacaine
;
Depression
;
Fistula
;
Humans
;
Kidney Failure, Chronic
;
Lidocaine
;
Male
;
Masks
;
Oxygen
;
Seizures
8.A Case of Localized Urticaria Induced by Mesotherapy.
Eun Jung KIM ; Sang Hyun CHO ; Jeong Deuk LEE
Korean Journal of Dermatology 2008;46(2):259-263
Mesotherapy is a widely used technique of intradermal or subcutaneous microinjection of a drug or cocktail of drugs, at sites of the body with medical or aesthetic problems. Rare cutaneous side effects have been previously reported, including allergic reactions to the administered drugs or skin infections. We herein report a case of an immediate adverse reaction following mesotherapy. A 40-year-old woman was referred to our department with pruritic erythematous urticarial plaques at the sites of application of mesotherapy. She had been treated for abdominal liposis with one session of multiple subcutaneous injections of a drug mixture including aminophylline at a local clinic. After clinical recovery, a skin test using the same drugs was performed. A positive intradermal test was found with aminophylline and ethylenediamine that is an ingredient of aminophylline. These results support that the ethylenediamine component of aminophylline is identified as the etiologic agent.
Adult
;
Aminophylline
;
Ethylenediamines
;
Female
;
Humans
;
Hypersensitivity
;
Injections, Subcutaneous
;
Intradermal Tests
;
Mesotherapy
;
Microinjections
;
Skin
;
Skin Tests
;
Urticaria
9.A case of acid pulmonary aspiration syndrome ( Mendelsons syndrome) during induction of anesthesia .
Korean Journal of Anesthesiology 1970;3(1):75-78
A case of Mendelson's syndrome during induction of anesthesia has been reported. The patient was treated with hydrocortisone IV, oxygen c IPPB, aminophylline and antibiotics. The patient recovered completely 3 days after aspiration. We must take the preventive measure for aspiration into the lung during anesthesia, especially obstetric patient.
Aminophylline
;
Anesthesia*
;
Anti-Bacterial Agents
;
Humans
;
Hydrocortisone
;
Intermittent Positive-Pressure Breathing
;
Lung
;
Oxygen
;
Pneumonia, Aspiration
10.The effectiveness of hyaluronidase for calcium gluconate-inducing extravasation necrosis : a dose and time response.
Hong Gi LEE ; Seung Han KIM ; Moo Hyun PAIK ; Seung Hong KIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(5):776-783
Extravasation necrosis due to intravenously administered fluids and drugs is an increasing problem in hospital practice. The incidence of extravasation is variable but skin necrosis is a potentially devastating complication of intravenous therapy. Local injection of hyaluronidase has been recommended for several types of infusion extravasations. The previous studies found hyaluronidase to be effective in the prevention of necrosis following intradermal nafcillin, 12% dextrose, sodium bicarbonate, aminophylline or vince alkaloids.The objectives of the study are to determine the dosage of hyaluronidase which is effective in reducing extravasation necrosis caused by 10% calcium-gluconate and to establish how soon after this extravasation it must be given to retain its effectiveness.Study I evaluated control versus only normal saline group and normal saline with hyaluronidase groups (dose:75,150,300,450 units; all in volume 2 ml, treatment delay:immediate, 15-minutes delay, half hour delay, one hour delay, three hour delay). Size and rate of eschar were compared between groups. Study II was undertaken to examine the evolution of calcium-gluconate induced soft tissue injury in the rabbit. The histologic findings of extravasation sites were compared between groups. A statistically significant protective effect was found in the treated group versus the nontreated group within 15 minutes to 30 minutes. The most effective protection was achieved by the immediate injection of 300 units dosage of hyaluronidase.In conclusion, in the 10% calcium gluconate-induced extravasation, the given data suggest that one can expect the most protective effect with a 300 units dosage of hyaluronidase and within half-hour delay in the treatment group.
Aminophylline
;
Calcium*
;
Glucose
;
Hyaluronoglucosaminidase*
;
Incidence
;
Nafcillin
;
Necrosis*
;
Skin
;
Sodium Bicarbonate
;
Soft Tissue Injuries