No Abstract Available.
Amblyopia*

PURPOSE: To evaluate the results of amblyopia on multifocal electroretinogram (mfERG). METHODS: The mfERG procedure was performed on nineteen monocular amblyopic patients (age ranged from 7 to 42 years) using the VERIS(TM) (EDI, San Mateo, CA) system. The central 30 degrees of ocular fundus were stimulated by an array of 103 hexagonal elements for four minutes. The responses of six concentric rings (rings 1 to 6) radiating from the foveal center were averaged, and the latencies and amplitudes of N1, P1 and N2 were compared with the findings of the normal contralateral eyes. The mfERG procedure was recorded again after improvement of vision in one patient (No. 4) who underwent occlusion treatment for one month. RESULTS: There were no significant differences of N1, P1 and N2 latencies between normal contralateral and amblyopic eyes (P>0.05). However, P1 amplitudes of the amblyopic eyes were reduced significantly compared with those of the normal contralateral eyes on rings 1 and 2 (P<0.05). N1 and N2 amplitudes of the amblyopic eyes were also reduced, but not significantly. After the successful occlusion treatment of patient No. 4, the responses of the amblyopic eye were improved but not the level of the contralateral normal eye. CONCLUSIONS: These results suggest that amblyopia may cause some changes in mfERG responses, especially in terms of amplitudes of the central retina. Further investigation is needed to determine whether these results are due to the physiologic change(s) of the amblyopia itself or to fixation instability during the test.
Amblyopia ; Humans ; Retina

Early discover and treatment is important for the prevention of amblyopia. When we discover ambloypia early, it is good for below 3 years old to do full occlusion theraphy. Thru the attempt of instruction for families, it is very good to find out obstacle etiology for normal developmental process of vision from childfood. It is need to do visual test before the the entrance to primary school.
Amblyopia* ; Child, Preschool ; Humans

Background: Optical coherence tomography (OCT) can accurately assess the optic nerve and retinal fiber layer (RNFL) to closely look at the anatomical ocular pathology of amblyopia. Objectives: This study aimed to determine and compare optic nerve parameters and RNFL in amblyopic and normal Filipino children using OCT. Methodology: Forty-two eyes of 21 normal participants and 40 eyes of 20 amblyopic participants underwent complete eye examinations and OCT scanning of optic nerve and RNFL. The following data were collected: age, refraction, intraocular pressure, optic nerve parameters (including rim area-vertical cross-section, average nerve width, disc diameter, cup diameter, rim length, vertical integrated rim area, horizontal integrated rim width, disc area, rim area, cup area, cup to disk area ratio, cup-to-disk horizontal ratio, cup to disc vertical ratio), and peripapillary RNFL. Results: There was a statistically significant difference between normal and amblyopic groups with regard to the following parameters: cup area, rim area, cup-disc area ratio, cup-disc horizontal ratio, cup-disc vertical ratio, superior RNFL, and inferior RNFL. The rim area was significantly smaller in amblyopic eyes compared to normal whereas the cup-disc area ratio, cup area, cup-disc vertical and horizontal ratios were significantly larger in amblyopic eyes. The RNFL inferiorly and superiorly were also thinner in amblyopic eyes. Conclusion As measured by OCT, some optic nerve parameters and RNFL thickness in Filipino children were significantly different in amblyopic eyes compared to normal.
Optic Nerve ; Amblyopia

Objective: To describe the clinical profile of patients with amblyopia seen at a Philippine tertiary hospital. Methodology: This was a cross-sectional study utilizing a chart review of children ages 6 months to 18 years old diagnosed with amblyopia at a Philippine tertiary hospital. Records with complete entry of history and ocular examinations were included. Verbal children with best-corrected visual acuity in both eyes of less than 6/15 or a 2 line difference between eyes were considered amblyopic. Response to alternate occlusion or refixation patterns was used as a basis for diagnosing amblyopia in pre-verbal children. Patients with visual deprivation amblyopia such as from cataract who had undergone lens extraction and optical correction were included. Results: There were 334 patients included in the study. The mean age was 5±3 years with 52% being male. Deprivation type of amblyopia was present in 192 (58%) patients, strabismic type in 81 (24%), and refractive type in 61 (18%). No sex predilection was observed. Majority of the patients were 3-6 years old on initial consult. Cataract was the most common cause of deprivation amblyopia affecting 127 (66%) patients. Strabismic amblyopia was present in 58 patients with 74% being esotropic. Anisometropic refractive amblyopia was more common at 37 (58%) than isometropic refractive amblyopia. Conclusion Visual deprivation amblyopia was the most common cause of amblyopia in a Philippine tertiary hospital.
Amblyopia ; Cataract ; Anisometropia ; Strabismus

PURPOSE: We schemed to help the therapeutic plan in amblyopic children of old age group by analyzing the clinical outcomes of occlusion therapy in amblyopic children more than 8 years old. METHODS: In 104 unilateral amblyopic children whose occlusion therapy had been finished, the retrospective study was performed. The average age at the beginning of treatment was 5.9 years (1.2~15.2 years). We divide the patients into three groups on the basis of age at the beginning of treatment: below 4 years (group 1, N=41), 5~7 years (group 2, N=44), more than 8 years (group 3, N=19). The success rate of occlusion therapy in group 3 was compared with the success rate of other groups, and the clinical features of group 3 were analyzed. RESULTS: The success rate of occlusion therapy in group 3 (68.4%) was significantly low compared with other groups (p<0.05). In group 3, the success rate of anisometropic amblyopia (90.0%) was significnatly higher compared with the success rate of strabismic amblyopia (44.4%)(P<0.05), and it was similar to the success rate of anisometropic amblyopia of other groups. CONCLUSIONS: The success rate of occlusion therapy in amblyopic children more than 8 years old was significantly lower compared with other groups. But the clinical outcomes were fair, especially in anisometropic amblyopia. We suggest to enforce occlusion therapy in amblyopic children more than 8 years old.
Amblyopia* ; Child* ; Humans ; Retrospective Studies

PURPOSE: To evaluate the clinical usefulness of the 10-prism-diopter (PD) fixation test in the diagnosis of amblyopia. METHODS: The study comprised 132 children (42 normal, 90 amblyopes) who underwent the 10-PD fixation test and stereoacuity test. The sensitivity, specificity, false-positive and false-negative rates of the 10-PD fixation test were analyzed according to the clinical diagnosis. RESULTS: The 10-PD fixation test sensitivity was 86%, the specificity was 61%, the false-positive rate was 17% and the false-negative rate was 24%. Data showed agreement between the 10-PD fixation test and the stereoacuity test (gamma=0.737, p=0.000). The results in the 10-PD base-down test and base-out test also showed agreement (gamma=0.779, p=0.000). CONCLUSIONS: The 10-PD fixation test is a simple and useful method in detecting amblyopia.
Amblyopia ; Child ; Humans ; Sensitivity and Specificity

PURPOSE: To study the effect of occlusion therapy in amblyopia according to the beginning time of occlusion therapy, type and depth of amblyopia. METHODS: The total 92 children, who had been treated with occlusion therapy were included in this study. Patients were divided into two groups according to the age when occlusion therapy was started: those with less than 7 years vs 7 years or older. Patients were also divided into three groups according to the type of amblyopia and depth of amblyopia: mild amblyopia with visual acuity 0.6 or more , moderate amblyopia with between 0.2 and 0.5 , and severe amblyopia with 0.1 or less. RESULTS: The children under 7 years old were 58 patients and 7 years or over was 34 patients. In patients less than 7 years, 70.7% achieved a successful treatment and in patients 7 years or more, 67.6% was in success. There was no significant difference between two groups. Among the moderate and severe amblyopic patients, 72.1% of patients under 7 year-old and of 44.4% of over 7 year-old achieved a successful treatment. According to the type of amblyopia, there was no significant difference between the groups. According to the depth of amblyopia, success rate of occlusion in mild, moderate and severe amblyopia was 80.6%, 67.9%, and 37.5% respectively. CONCLUSIONS: The success rate was higher in younger group than older group in moderate and severe amblyopia. The depth of amblyopia affected the final visual outcome, and occlusion therapy was more effective in less severe amblyopia.
Amblyopia* ; Child ; Humans ; Visual Acuity

VEP(Visual Evoked Potential) is being widely used as a diagnostic method in amblyopia. In order to assess the visual improvement during occlusion therapy and VEP change between pre and post-occlusion therapy in amblyopia, 32 amblyopic chi1dren ranging from 3 to 13 years old were investigated. The results were as follows: 1. Among 21 cases of visual improvement above 2 lines with Han's visual acuity chart, occlusion therapy was effective in 73.7% of strabismic amblyopia, and 87.5% of anisometropic amblyopia. The mean period of visual improvement above 2 lines was 2.2 months. 2. As compared to non-amblyopic eye, VEP amplitude of amblyopic eye was significantly reduced. 3. There was no statistic significance of P3 latency between amblyopic and non-amblyopic eyes. 4. As compared to control group, the side difference of amblyopic group was significantly increased. 5. With visual improvement above 2 lines, increase of amplitude was revealed 87.5% and decrease of side difference was revealed 87.5% in 10 cases of investigating VEP change. 6. In 7 eyes of visual improvement above 2 lines, change of P2 latency between pre-occlusion and post-occlusion therapy revealed no significance statistically.
Adolescent ; Amblyopia* ; Humans ; Visual Acuity

Objective: To determine the visual outcome of amblyopia treatment and describe the relationship between age of onset and consult, compliance as measured by a patch diary, amblyopia subtype, and severity with the final visual outcome. Methods: Thirty-two consecutive, newly-diagnosed cases of amblyopia, aged 3-8 years on initial consult, with no history of prior amblyopia treatment, were included. Patching was done based on current AAO recommendations and patients were followed up monthly for 6 months. Treatment success was defined as best corrected visual acuity (BCVA) better than 20/30 (0.17LogMAR), or a 3-line improvement from baseline, or stable isoacuity for at least 3 months. Treatment failure was defined as no improvement of BCVA after 3 months of occlusion therapy or a regression of 2 lines. Descriptive and correlation statistics were performed comparing age of onset and consult, amblyopia subtype, severity, and compliance with the main outcome measure of BCVA at 6 months. Results: Sixteen (50%) attained treatment success. Patients seen earlier (age 2-5 years) had higher rates of success (75%) than those seen later (age 6-8 years) (35%). A moderately strong negative correlation (r=-0.48, p=0.01) existed between severity of amblyopia and final BCVA at 6 months. overall compliance to patching was 88±18%, with good compliance in the success group (92%) compared to fair compliance in the failure group (84%) and a moderate correlation between compliance and BCVA (r=0.37, p=0.05). Conclusion Treatment success was related to severity, compliance, and younger age of treatment. In the presence of good compliance, severity was a strong prognostic variable.
Amblyopia ; Compliance ; Sensory Deprivation ; Anisometropia