1.Quality Characteristics and Optimization of Rice Muffin Containing Chinese Artichoke (Stachys sieboldii MIQ) Powder Using Response Surface Methodology.
Young Il PARK ; Sun Mee LEE ; Nami JOO
Journal of the Korean Dietetic Association 2014;20(3):212-226
The purpose of this study was to determine the optimal composite recipe of rice muffin using three different amounts of Chinese artichoke (Stachys sieboldii MIQ) powder, brown sugar, and egg. Response surface methodology (RSM) was used to obtain 16 experimental points (including three replicates of Chinese artichoke powder, brown sugar, and egg), and the Chinese artichoke rice muffin formulation was optimized using rheology. The results of the sensory evaluation showed very significant values for color, texture, sweetness, and overall quality (P<0.05). The results of the color, texture, and chemical analyses showed significant values for crumb redness (P<0.01), crumb yellowness (P<0.05), crust redness (P<0.05), crust yellowness (P<0.001), crust lightness (P<0.05), adhesiveness (P<0.01), springiness (P<0.001), gumminess (P<0.01), cohesiveness (P<0.05), moisture content (P<0.05), and sweetness (P<0.05). As a result, optimum formulations obtained by numerical and graphical methods were found to be 8.28 g of Chinese artichoke powder, 66.20 g of brown sugar, 111.72 g of sticky rice powder, 30 g of rice powder, and 59.37 g of egg.
Adhesiveness
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Asian Continental Ancestry Group*
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Cynara scolymus*
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Humans
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Ovum
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Rheology
2.Effects of material interfaces on orientation and function of fibrinogen.
Yong CHEN ; Jianfang REN ; Jianhua WU ; Ying FANG
Journal of Biomedical Engineering 2021;38(6):1087-1096
Fibrinogen (Fg) in human plasma plays an important role in hemostasis, vascular repair and tissue integrity. The surface chemistry of extracellular matrix or biological materials affects the orientation and distribution of Fg, and changes the exposure of integrin binding sites, thereby affecting its adhesion function to platelets. Here, the quantity, morphology and side chain exposure of Fg adsorbed on hydrophilic, hydrophobic and avidin surfaces were measured by atomic force microscopy (AFM) and flow cytometry (FCM), then the rolling behavior of platelets on Fg was observed through a parallel plate flow chamber system. Our results show that the hydrophobic surface leads to a large amount of cross-linking and aggregation of Fg, while the hydrophilic surface reduces the adsorption and accumulation of Fg while causing the exposure and spreading of the α chain on Fg and further mediating the adhesion of platelets. Fg immobilized by avidin / biotin on hydrophilic surface can maintain the monomer state, avoid over exposure and stretching of α chain, and bind to the platelets activated by the A1 domain of von Willebrand factor instead of inactivated platelets. This study would be helpful for improving the blood compatibility of implant biomaterials and reasonable experimental design of coagulation
Adsorption
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Blood Platelets
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Fibrinogen
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Humans
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Platelet Adhesiveness
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von Willebrand Factor
3.Study on adhesion of platelets to surface of copoly(benzyl glutamate-hydroxy ethyl glutamine).
Shirong PAN ; Wu YI ; Qinmei WANG
Journal of Biomedical Engineering 2002;19(4):572-575
Copoly (benzyl glutamate-hydroxy ethyl glutamine) were prepared by partially aminolysis of poly benzyl glutamate with hydroxyl ethylamine at 60 degrees C for predeternined period. As aminolysis was proceeding, the content of hydroxy ethyl glutamine in copolymer increased and the yield of aminolysis decreased. When aminolysis time reached 16.5 hours, a copolymer with 0.357 mole fraction of hydroxy ethyl glutamine was obtained. After 16.5 hours a soluble yellow viscous product of reaction was obtained. The aminolysized specimens displayed more swelling degree in water, that is, more hydrophilits. The meassurement of solid-liquid contact angles showed that an increase in critical surface tention with content of hydroxy ethyl glutamine in copolymer was observed. Likewise a obvious increase in polar component and a slight decrease in dispersive of surface free energy, thus an increase in total surface free energy with content of hydroxy ethyl glutamine was found. The platelet adhesion and deformation test indicated that less platelets were adhered to surfaces of all aminolysized specimens than that of both poly benzyl glutamate and polydimethylsilicone. The least adhered platelets on surface of copolymer with 0.133 mole fraction of content of hydroxy ethyl glutamine were observed. The partiall aminolysis of poly benzyl glutamate films is an effective method to improve its hydrophility and antithrombogenicity.
Animals
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In Vitro Techniques
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Male
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Materials Testing
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Platelet Adhesiveness
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Polyglutamic Acid
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analogs & derivatives
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chemistry
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Rabbits
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Surface Properties
4.Insight into surface structure and hemocompatibility of fluorinated poly(ether urethane)s and poly(ether urethane)s blends.
Hong TAN ; Jiehua LI ; Xingyi XIE ; Min GUO ; Qiang FU ; Yinping ZHONG
Journal of Biomedical Engineering 2004;21(4):566-569
It has been well known that fluorinated polyurethanes exhibit unique low surface energy, biocompatibility, biostability and nonsticking behavior. Consequently, these polymers have attracted considerable interest. In this study, the effect of various concentrations of fluorinated polyurethanes in the polyurethanes on the surface structures of the blends and their hemocompatibility were investigated by XPS, AFM, contact angle and platelet adhesion. It was found that the high concentration fluorine on the outer surfaces of the blends obtained with the low concentration of fluorinated polyurethanes (F: 0.342 wt%) in the blends was the same as that of the fluorinated poly(ether urethane)s, and all of the blends and the fluorinated poly(ether urethane)s had good hemocompatibility, compared with poly(ether urethane)s. The polymer blends and fluorinated poly(ether urethane)s suppressed platelet adhesion due to their high hydrophobicity and low surface tension. The XPS, AMF and contact angle results indicated that the high hydrophobicity of outer surface of the polyurethane blends is independent of the fluorinated polyurethanes content in the polymer blends but related to the concentration of the CF3 groups because the lower critical surface tensions and higher contact angle of many fluorinated surfaces reflect the concentration of CF3 groups.
Coated Materials, Biocompatible
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chemistry
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Ethers
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Fluorine
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Humans
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Platelet Adhesiveness
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Polyurethanes
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chemistry
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pharmacology
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Prostheses and Implants
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Surface Properties
5.Microstructure and adhesion of HAP-glass-alumina composite gradient bioceramics coating.
Zhiqiang WANG ; Xiaoxu CHEN ; Yingji CAI ; Bingling LÜ
Journal of Biomedical Engineering 2005;22(1):70-73
HAP-Glass-alpha-Al2O3 gradient coating on alumina ceramics substrate was prepared by multi-layer slurry-dipping and sintering process, effects of the composition of the coating on the microstructure and adhesion strength of the gradient coating were studied. R2O-Al2O3-B2O3-SiO2 system glass with low softening temperature and thermal expansion was used in the gradient coating. The composition of the coating was varied from interface to surface layer, i.e. the HAP concentration increased and glass concentration decreased gradually from the under layer to the surface layer. A suitable amount superfine alpha-Al2O3 was added in the gradient coating to reinforce the bonding strength between the coating and substrate. The results show that the use of R2O-Al2O3-B2O3-SiO2 system glass is propitious to sintering the coating at low temperature and to combination between the coating and substrate. The addition of superfine alpha-Al2O3 can reinforce the bonding strength between the coating and substrate, the highest bonding strength is about 48.2 MPa.
Adhesiveness
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Aluminum Oxide
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chemistry
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Ceramics
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chemistry
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Coated Materials, Biocompatible
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chemistry
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Durapatite
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chemistry
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Glass
;
chemistry
6.Analysis of Grey correlation between surface energy and adhesive characteristic of platelet for DLC.
Bogang LI ; Jie YIN ; Juanjuan NA ; Guangfu YIN ; Changqiong ZHENG
Journal of Biomedical Engineering 2005;22(1):20-24
In this study, the diamond like carbon (DLC) samples made from different processes and processing conditions, were subjected to the test of platelet adhesion. The surface energy parameters such as surface tension, critical surface tension, interface tension, adhesive power, and polar branch and chromatic dispersion branch of surface tension based on determining balanced contact angle of ethanol, water and different ratios of ethanol/water solution on surfaces of the samples were calculated, respectively. Then the effects of these parameters on the amounts and deformation index of the platelets adhering to the samples were assessed by analyzing the T-type correlation degree in the Grey system. The results showed: (1) all degrees of correlation between surface energy parameters and adhesion amounts of platelet are positive, but for deformation index, the correlation degrees are negative except for critical surface tension; (2) the adhesion amounts of platelet increase with the rising polar branch of surface tension, while the deformation index increases with rising chromatic dispersion branch of surface tension; (3) Both adhesion amounts and deformation index of platelet are positively correlated with critical surface tension to a higher degrees; (4) the effects of polar branch of surface tension on adhesion amounts and deformation index of platelet keep pace with the surface tension, interface tension and adhesive power. Thus two important conclusions have been obtained: (1) the adhesive characteristic of platelets to the surface of DLC is closely related with the surface energy of DLC; the hemocompatibility of DLC is decided by the balance between the polarity of DLC surface and the limited humidifying water on the surface; there is a blood compatible range delimited by critical surface tension; (2) adhesion and deformation of platelets on surface of DLC have different energy mechanism: polar surface is advantageous to the adhesion, while the deformation is achieved with the aid of chromatic dispersion action stem from the surface.
Biocompatible Materials
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chemistry
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Carbon
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chemistry
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Diamond
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chemistry
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Humans
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Materials Testing
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Platelet Adhesiveness
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Surface Properties
7.Studies on the blood compatibility of the polyurethane/nano-sized carbon composite.
Hai-yan XU ; Hua KONG ; Chang-yan LIN ; Bing-yi LI
Acta Academiae Medicinae Sinicae 2002;24(2):114-117
OBJECTIVETo investigate the effects of nano-sized carbon as a dispersed phase on blood compatibility of polyurethanes.
METHODSA novel nanoscale polymeric composite film was prepared by dispersing nano-sized carbon fiber (vapor growth carbon fiber) into the polyurethane solutions. The surface blood compatibilities of the composites were analyzed and evaluated through platelet adhesion measurement using epifluorescent video microscopy and the variation of fibrinogen and free hemoglobin concentration in the blood contacting the composite respectively.
RESULTSIt was showed that the platelet adhesions were highly suppressed on the composite surfaces pre-adsorbed or non-pre-adsorbed with fibrinogen. The changes of the concentration for both free hemoglobin and fibrinogen in the blood contacting the composite surface in the circulations were less than the ones contacting the reference surface.
CONCLUSIONSIntroducing nano-sized carbon into the polyurethane matrix showed an improvement of antithrombogenicity for the polyurethane materials. It might be a new promising way to develop biomaterials with good blood compatibility.
Biocompatible Materials ; Blood ; Blood Coagulation ; Carbon ; Humans ; Materials Testing ; Nanotechnology ; Platelet Adhesiveness ; Polyurethanes
8.Evaluating method of the characteristic physical properties of the wetting mass using texture analyser.
Ya GAO ; Yan-long HONG ; Jie-chen XIAN ; Ning ZHANG ; Yi FENG ; Xiu-juan YANG
Acta Pharmaceutica Sinica 2012;47(8):1049-1054
To build the evaluating method of the characteristic physical properties of the wetting mass, this study reported the preparation of wetting mass by adding water into microcrystalline cellulose, and using texture analyser texture profile analysis to test its physical properties, including hardness, adhesiveness, springness, cohesiveness, chewiness, resilience and so on, then finding out the better method and parameters. The method was evaluated and used to test wetting mass, which was made of microcrystalline cellulose of different types and polyvinylpyrrolidone. When running texture profile analysis whose trigger force was 1500 g, the relative standard deviation was under 10%, and the trend of every characteristic physical property tallied with the theory result by water ratio increase. Testing result of the same excipient with the same water ratio had a higher precision, while characteristic physical properties of wetting mass who was made of the same excipient with different water ratios and different excipients had a great difference. Using texture analyser to test physical properties of wetting mass could get a result which tallied with the theory by water ratio increase, and had a well precision, accuracy and sensitivity, and thus it could also evaluate the characteristic physical properties of wetting mass relatively well.
Adhesiveness
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Cellulose
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chemistry
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Excipients
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chemistry
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Hardness
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Povidone
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chemistry
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Surface Properties
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Technology, Pharmaceutical
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methods
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Water
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chemistry
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Wettability
9.A handy way to handle hemoclips(®) in surgeries.
Shunjie CHUA ; Mark PITTS ; Peter LEMARK ; Min LE ;
Singapore medical journal 2015;56(12):695-695
10.Postmortem Change of Adhesive Forces Between the Retina and the Retinal Pigment Epithelium.
Journal of the Korean Ophthalmological Society 1993;34(2):111-116
Adhesive forces between the retina and the retinal pigment epithelium, which is mainta ined by active mechanisms unique for living animals, deteriorates rapidly after death and leads to spontaneous retinal detachment. Change of retinal adhesiveness in rabbits after death was investigated using a new method. Retinal detachment was induced by applying various levels of aspiration power from 0 to 1OO mmHg to the vitreous cavity using a vitrectomy instrument immediately after the rabbit was killed without enucleation. And the time required for creating the retinal detachment was measured. Retinal adhesiveness deteriorated and spontaneous retinal detachment occurred 28 minutes and 35 seconds after death confirming the active adhesion between the retina and the retinal pigment epithelium before death Increase of aspiration power led to shortening of time required for creating retinal detachment. From aspiration powers of 0 to 100 mmHg, the common logarithm of time required for retinal detachment was inversely proportional to the aspiration power [IogY = 1.45215 - 0.01113X, (R2=0.99041), X: aspiration power (mmHg), Y: time required for creating retinal detachment (minutes)]. Thus, presumed time of retinal detachment could be estimated between the aspiration powers of 0 to 100 mmHg.
Adhesiveness
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Adhesives*
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Animals
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Postmortem Changes*
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Rabbits
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Retina*
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Retinal Detachment
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Retinal Pigment Epithelium*
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Retinaldehyde*
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Vitrectomy