Diagnosis, Differential ; Esophageal Neoplasms ; pathology ; surgery ; Granuloma, Pyogenic ; pathology ; surgery ; Hemangioma, Capillary ; pathology ; Hemangiosarcoma ; pathology ; Humans ; Male ; Middle Aged ; Sarcoma, Kaposi ; pathology

Objective To evaluate the efficiency and safety of rivaroxaban and dabigatran for anticoagulant therapy which is a treatment for atrial fibrillation patients undergoing catheter ablation.Methods CNKI,VIP Database,Wangfang Database,PubMed,Web of science,EmBase and Cochrane library were searched until 2016-12-15.All clinical trials about anticoagulant therapy of rivaroxaban and dabigatran in patients undergoing catheter ablation for atrial fibrillation were selected.And research quality evaluation was done using RevMan5.3 software for Meta analysis.Minimum cost analysis method was used for economic evaluation.Results A total of 6 observational study and 1 randomized controlled trials met the inclusion criteria.Compared with dabigatran,rivaroxaban has no statistically significant differences in thromboembolism (RR =1.03,95％ CI =0.27-4.00,P ＞0.05),major bleeding (RR =1.02,95％CI =0.42-2.48,P ＞0.05),strokes (RR =0.87,95％CI =0.17-4.60,P ＞0.05),but there was statistical significance in costs between two groups(P ＜ 0.05).Conclusion Rivaroxaban and dabigatran have similar effectiveness and safety in anticoagulant therapy for patients undergoing catheter ablation for atrial fibrillation,but dabigatran has economic advantage.

Objective To evaluate the efficacy and safety of recombinant human interleukin-11 (rhIL-11) in patients with thrombocytopernia after chemotherapy.Methods Using the method of evidence-based medicine,all the parallel controls of rhIL-11 combined with standard therapy and standard therapy computer-aided search of China National knowledge infrastructure (CNKI),VIP-Chinese science and technology periodical database,Wanfang data knowledge service platform,Cochrane Library,PubMed and Wed of Science.The Meta-analysis of the data was carried out by using RevMan 5.3 software.Results Totally 15 literatures were included in this series,with a total of 734 patients,including 370 cases in treatment group,other 364 cases in control group.The results of Meta-analysis showed that the platelet count in treatment group shorten the time interval of blood platelet ≤ 50 × 109/L duration (MD=-3.51,95％ CI:-4.66-2.36,Z=5.97,P＜0.01),shorten the duration of platelet recovery ≥ 100 × 109/L (MD =-3.20,95％ CI:-3.86-2.53,Z =9.38,P ＜ 0.01),proportion of platelet infusion(MD =-3.88,95％ CI:-6.15-1.61,Z =3.35,P ＜0.01) were better,and the proportion of adverse drug reaction of treatment group was lower than standard therapy (OR =0.17,95％ CI:0.09-0.32,Z =5.40,P ＜ 0.01).Conclusion RhIL-11 treatment of thrombocytopenia after chemotherapy is effective,significantly improve the patient's platelet count,shorten the duration and recovery time of thrombocytopenia,and better safety.

Objective To investigate the extrinsic stain removal efficacy of two commerciallyavailable dentifrices (LION (R) ZACT(R) ).Methods After informed consent was assigned,148 male smokers,aged 19-60 yeas,were recruited in this study.In this double blind,randomized,parallel study,three groups were balanced according to Lobene stain index ( including area and intensity) at baseline and then randomly assigned into three treatment groups:Toothpaste A containing 2％ alumina or Toothpaste B containing 0.5％ four sodium pyrophosphate,Toothpaste C:control dentifrice.Stain level was assessed by one qualified examiner at baseline,4 weeks and 8 weeks after baseline.Results After 4-week use of the assigned dentifrices,the groups using Toothpaste A and B demonstrated significant stain area reduction of 8.48％ and 7.14％,with stain intensity reduction of 5.29％ and 4.23％ compared with the control group ( P ＜ 0.05 ).After 8-week use of Toothpaste A and B,the two groups demonstrated a significant ( P ＜ 0.01 ) stain area reduction of 15.31％ and 14.83％,with stain intensity reduction of 12.65％ and 13.86％,as compared to the control group.Conclusions The dentifrices containing 2％ alumina or 0.5％ four sodium pyrophosphate are effective for the removal of extrinsic tooth stain after four weeks,and eight weeks of use.

Aorta, Thoracic ; pathology ; Child ; Child, Preschool ; Female ; Heart Defects, Congenital ; diagnosis ; mortality ; Humans ; Infant ; Infant, Newborn ; Male ; Vascular Malformations ; diagnosis ; mortality

OBJECTIVETo investigate the effects of electromagnetic radiation on the physiological indices and immune function of operators.

METHODSThe general conditions and electromagnetic radiation awareness rate of 205 operators under electromagnetic radiation were evaluated using a self-designed questionnaire. Physical examination, electrocardiography, and routine urine test were performed in these operators. Peripheral blood was collected from the operators under electromagnetic radiation for blood cell counting and biochemical testing, and their peripheral blood lymphocytes were cultured for determination of chromosomal aberrant frequency and micronucleus frequency. The data from these operators (exposure group) were compared with those of 95 ordinary individuals (control group).

RESULTSThe chief complaint of giddiness, tiredness, dizziness, and amnesia showed significant differences between the exposure group and control group (P < 0.01), and the difference in headache became larger with an increase in working years. The awareness rate of electromagnetic radiation damage was significantly higher in the exposure group than in the control group. The difference in bradycardia was significant between the two groups (P <0.01), and the incidence was higher with longer working years. Significant differences between the two groups were also found in the numbers of individuals with elevated alanine aminotransferase, total bilirubin, and direct bilirubin (P < 0.01), populations with increased lymphocyte ratio and decreased neutrophil ratio (P < 0.01), populations with positive occult blood, urobilinogen, and bilirubin tests, and the number of individuals with increased micronucleus frequency of cultured peripheral blood lymphocytes (P < 0.01). In addition, the exposure group had significantly increased complement C3 and C4 (P < 0.01), significantly increased IgG (P < 0.05), and significantly decreased IgM (P < 0.01), as compared with the control group.

CONCLUSIONElectromagnetic radiation may lead to the changes in physiological indices, genetic effects, and immune function and affect the health and immune function in operators. The adverse effects are increased as the working years increase. So it is important to strengthen occupational protection of operators under electromagnetic radiation.

Adult ; Chromosome Aberrations ; radiation effects ; Electromagnetic Radiation ; Female ; Humans ; Lymphocytes ; radiation effects ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Young Adult

On the base of element and metablism balancing, the mathematical model of the cultivation process with Streptomyces aureofaciens was developed, and the unknown parameters in the model were estimated with the method of nonlinear optimization. Firstly the energetic coefficient of CTC biosynthesis was gained, which was 1.8 - 2.8 mol-ATP x C-mol(-1). The macroscopic reaction rates were predicted in the process and compared with the experimental values. The results show that the model can preferably describe the relationships between several macroscopic reaction rates in the process and can supervise the optimization of CTC fermentation process theoretically.
Chlortetracycline ; metabolism ; Fermentation ; physiology ; Models, Theoretical ; Streptomyces aureofaciens ; growth & development ; metabolism

OBJECTIVETo study the effects of beta-asarone on expression of immediately early gene c-fos in kindling epilepsy rat brain.

METHODThe rats were randomly divided in to beta-asarone groups (200, 100, 50 mg x kg(-1) x d(-1)), difetoin control group (36 mg x kg(-1)) and model group. The remedy was administered orally. The effects were observed in kindling epilepsy model induced by penicillin, then the expression of c-fos were determined by western blot (hippocampus) and immunohistochemical techniques (cortex).

RESULTBeta-asarone could significantly increase the expression of c-fos in kindling epilepsy rat brain, and show its quantity-effect relation. The expression of c-fos in hippocampus was (1139.45 +/- 155.56), (1109.56 +/- 134.03), (1103.73 +/- 235.82) CNT x mm2 in beta-asarone groups, 920.54 +/- 203.20 in model control group, and 1106.26 +/- 186.24 in difetoin group, respectively. The number of c-fos positive cell was 87.1 +/- 2.2, 76.3 +/- 1.3 and 59.9 +/- 1.3 in beta-asarone groups, 39.3 +/- 2.6 in model control group, and 95.2 +/- 1.1 in difetoin group, respectively.

CONCLUSIONBeta-asarone can obviously increase the expression of c-fos in epilepsy rat brain. It is one of important response to epilepsy.

Animals ; Anisoles ; pharmacology ; Blotting, Western ; Brain ; drug effects ; metabolism ; Epilepsy ; drug therapy ; metabolism ; Female ; Gene Expression ; drug effects ; Immunohistochemistry ; Male ; Proto-Oncogene Proteins c-fos ; metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley

Objective To evaluate the clinical effect of Qianlie Yikang capsules on the levels of prostaglandin E2 (PGE2) and interleukin-8 (IL-8) in serum and prostatic fluid in patients with nonspecific prostatitis.Methods Eighty patients with nonspecific prostatitis were randomly divided into control group and treatment group,40 cases in each group.Control group was orally given Pule'an tablets 2.0 g,3 times a day.Treatment group was treated with Qianlie Yikang capsules 1.5 g,3 times a day,orally.Before and after treatment,the levels of serum and prostatic fluid PGE2,IL-8 and clinical efficiency in two groups were compared.Results The clinical efficiency of treatment group was 92.50％ (37/40 cases),had significant difference with that in control group,which was 75.00％ (30/40 cases,P ＜ 0.05).After treatment,the serum PGE2 of treatment group and control group were (159.76 ± 16.34),(190.65 ± 17.56) ng · L-1,IL-8 were (2.28 ± 0.32),(3.08 ± 0.22) ng· L-1,with significant difference (P ＜ 0.05).After treatment,the prostatic fluid PGE2 of treatment group and control group were (227.46 ±20.84),(309.46 ± 19.39) ng·L-1,IL-8 were (3.12±0.43),(4.77 ± 0.67) ng · L-1,with significant difference (P ＜0.05).There was no significant adverse reactions in two groups.Conclusion The Qianlie Yikang capsules can significantly reduce the serum and prostatic fluid PGE2,IL-8 levels in patients with nonspecific prostatitis,and have good clinical effect.

OBJECTIVETo investigate the clinical effects of Pizhen for the treatment of supraclavicular nerve-entrapment syndrome.

METHODSFrom March 2004 to April 2006, among the 200 patients of supraclavicular nerve-entrapment syndrome, 100 patients (75 patients were male and 25 patients were female, ranging in age from 25 to 65 years, with an average of 45 years)were treated with Pizhen, 100 patients (60 patients were male and 40 patients were female, ranging in age from 16 to 63 years, with an average of 35 years) were treated with Acupuncture. The therapeutic effects of the two groups were compared.

RESULTSAll the patients were followed up and the duration ranged from 6 to 12 months, 9.6 months in average. Among the patients in Pizhen group, 79 patients got an excellent result, 12 good, 8 fair, and 1 poor, and the tension exponent of soft tissues decreased from preoperative 3.56 +/- 0.35 to postoperative 2.11 +/- 0.41. In the control group, 43 patients got an excellent result, 21 good, 17 fair, and 19 poor, the tension exponent of soft tissues decreased from preoperative 3.61 +/- 0.21 to postoperative 3.13 +/- 0.56. The therapeutic effects and tension exponent of soft tissue in the two groups had statistical differences (P < 0.05 and P < 0.01).

CONCLUSIONThe clinical effect of Pizhen is better than the the acupuncture for the treatment of supraclavicular nerve-entrapment syndrome. The therapy of Pizhen is safe, good and easily to practice.

Acupuncture Therapy ; methods ; Adolescent ; Adult ; Aged ; Brachial Plexus ; Female ; Humans ; Male ; Middle Aged ; Nerve Compression Syndromes ; therapy