Group B Streptococcus ( GBS) is a conditional pathogenic bacteria related to late-term abortion, premature delivery, premature rupture of membranes, perinatal infection, neonatal sepsis and other diseases.Prevention and treatment guidelines by the US Centers for Disease Control and Prevention ( CDC) suggest that all the pregnant women at 35-37 gestational weeks should screen for GBS .The detection methods for GBS include microbiology , immunology, molecular biology, etc.The appropriate method should be chosen depending on circumstances .Penicillin is recommended for the preventive treatment of GBS , and the treatment for the insensitive should base on the antibiotic susceptibility results .No vaccine against GBS is currently available for clinical use .

Target-oriented drug delivery systems(TODDS) of Chinese materia medicia(CMM) is ascribed as preparations in which active fractions or single ingredient extracted from CMM or natural medicines are directly delivered with the help of different carriers to target organs,target tissues,and target cells or intracellula.Recent advances of research on TODDSs of CMM classified according to carriers,such as liposomes,microspheres,nanocapsules,and emulsions are reviewed.In addition,due to the specific actions of CMM on intestinal diseases,oral colon targeting drug delivery system is considered substantials for TODDSs of CMM.Domestic researches on TODDS of CMM in its initial stage are limited to formulations using single natural active ingredient as raw material.While the fewer TODDSs using CMM active fractions or formula recipes are underway,which relates to the tremendous difficulties in both establishment of quality standard for CMM active fractions and technology for preparation of CMM.Nevertheless one of the important goals for the development on preparation of CMM is TODDS.

Objective:To further investigate the effects of three kinds of material on the level of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in gingival crevicular fluid (GCF). Methods:The anterior teeth and the premolar teeth of 30 patients were divided into three groups randomly for Co-Cr alloy PFM, Ti PFM and all ceramic crown. Before tooth preparation, 1, 3 and 6 months after cementation, GCF was collected at the same sites. The levels of AST and ALP were detected by automated chemical analyzer, and analyzed the variation between the pre-restoration and post-restoration. Results:Before tooth preparation and 1 month after cementation, all indexes showed no difference among three groups. The level of GCF, AST and ALP of Co-Cr alloy group showed conspicuous difference with Ti PFM and all ceramic crowns after 3 months and 6 months. However, the levels of GCF, AST and ALP of Ti PFM group showed no difference with all ceramic crowns. Conclusion:Co-Cr based PFM crowns which clinically accepted have lead to changes of the levels of GCF, AST and ALP. Co-Cr based PFM crowns have negative influences on periodontal tissue. The Ti PFM and all ceramic crown may affect periodontium less than the Co-Cr PFM in observation period of this study.

Since recombinant human growth hormone (rhGH) was licensed for growth hormone deficiency(GHD) in 1985,it has been available in short stature associated with Turner syndrome (TS),being born small for gestational age,idiopathic short stature,chronic renal insufficiency in the last 20 years.The overall safety profile of rhGH continues to be favorable,but careful monitoring for the presence of certain conditions is important both during and after therapy.Reasonable indication,time of therapy and dosage are important to obtain the ideal result and save the expense.Besides,the efforts to improve rhGH therapy and increase compliance have also led to the investigation of extended-release rhGH and less invasive administration routes.Recent advances in the treatment of rhGH are reviewed in details.

ObjectiveTo discuss the clinical value of mechanical ventilation in treatment the children with critical hand foot and mouth disease (HFMD) complicated with neurogenic pulmonary edema.MethodsThe clinical manifestations,laboratorydata,treatment,and outcome of 35 children with critical HFMD complicated with neurogenic pulmonary edema were retrospectively analyzed.Results35 cases had fever,34 cases had skin rash,33 cases had limb jitter,30 cases were easily frightened,30 cases lack of energy,34 cases had respiratory rhythm changes,18 cases vomited foam,18 cases poured pink in nose and mouth,22 cases had disturbance of consciousness,8 cases had flaccid paralysis.There were 30 cases with bilateral pulmonary exudative lesions in Chest X-ray.35 children were given mechanical ventilation based on the comprehensive treatment,and 3 cases of lower limb mobility impairments,12 cases died of pulmonary hemorrhage within 24 hours of admission,the rest was released.ConclusionEarly mechanical ventilation based on the comprehensive treatment is an important measure of successful treatment in children with critical HFMD complicated with neurogenic pulmonary edema.

The Chinese University students have low enthusiasm in classroom participation,so the classroom atmosphere is inactive.This article elaborates this point from three aspects such as how to cultivate the students' sense of classroom participation and enhance the English teaching quality.

Cooperative learning is a system of teaching pattern known for its contribution to the improvement of the class teaching effect,which has been successfully applied in middle schools and secondary vocational schools. Its application to oral English teaching for international nursing majors in higher vocational colleges can not only promote the students’oral English and communicative ability,but also help to cultivate their consciousness of cooperation and team work.

Several multi-gene assays have been developed to predict the risk of recurrence in patients with early-stage, estrogen receptor (ER) positive breast cancer. Among them, Oncotype DX 21-gene assay is widely applied among node-negative patients because of its unique prediction of therapeutic benefit. Although many retrospective stud-ies have proved its prognostic and predictive value in node-positive population, evidence from large prospective clinical trials remains insufficient. When combined with clinicopathological variables, the assay has been shown to impact adjuvant treatment decision making in a cost-effective manner. This article reviewed the available clinical evidence for the prognostic and predictive value, unique advantages, the effect on treatment decision making, cost-effectiveness and contradictories of 21-gene assay in early-stage luminal breast cancer patients.

The author first argues that the significance of sectionalizing the medical market is that it is conducive to the discovery of market opportunities; it is conducive to the possession of a greater market share; and it provides a basis for the hospital to identify its target market. Then he sets forth the requirements for sectionalizing the medical market, viz. measurability, accessibility, relative stability, and availability of benefit. Finally he expounds the classification methods when sectionalizing the medical market and the principles for a hospitals selection of a target medical market. These include an appropriate scale and market, a certain purchasing power and endurance, a market not yet completely monopolized by competitors, a market the hospital is capable of managing, a relatively steady social environment, and observance of the procedure for selecting a target medical market.