Thyroglobulin antibody (TGA) production in vitro by cultured peripheral blood mononuclear cells (PBMC) from patients with autoimmune thyroid disease (AITD) was measured by ELISA technique. PBMC from patients with AITD could synthesize and secret detectable amount of TGA. The average positive rate of TGA production in vitro was 31.25%. PBMC from the patients with Hashimoto thyroiditis (HT) could produce TGA more easily than that from the patients with Graves'disease (GD). The average positive rate was 44.19% in HT and 16.22% in GD. Pokeweed mitogen could increase TGA production, but soluable thyroglobulin could not stimulate TGA synthesis and secretion. Antithyroid drug methi-mazole had some inhibition effect on TGA production in vitro. A significant positive correlation between the serum TGA and the amount of TGA produced in vitro by PBMC from HT patients (r = 0.4, P

Lithium(Li) salt is. a kind of effective drug commonly used in the treatment and prevention of mental disorders, but its active mechanism is still not well understood. Getting on for twenty years, many research have been reported on relationship between Li salt and second messenger system, especially the effect of Li salt on adenylate cyclase. Identical result is not obtained and there are few reports on brain calmodulin (CaM) activity change by Li salt. The aim of present expcri- ment is to determine the content of CaM in raet brain by phosphodiesterase (PED) method after chronic application of Li salt and discuss preliminary the molecular mechanism of Li salt action. The result showed that marked change has happened in the content of CaM in rat brain after chronic application of Li salt. It is ins-plied that Li salt brings its action into play probably by changing the content of CaM in rat brain

The annual incidence of prostate cancer (PCa) continually increases. New PCa immune therapy has become the fourth line antitumor treatment following surgery, radiotherapy and chemotherapy. As the most promising research direction in cancer immunotherapy,immune checkpoint inhibitors, such as programmed cell death-1 and programmed cell death-ligand 1 (PD-1/PD-L1) inhibitors, block PD-1 and its ligand PD-L1 and then terminate the negative control signal to the T cell, thereby facilitating T cell recovery and reversal of tumor immune-escaping mechanism. These processes restore the capability of T cells for immune response and inhibit and kill tumor cells. This review summarizes the progress on the current application of PD-1/PD-L1 inhibitors in PCa clinical trials.

Medicine, Chinese Traditional ; Teaching ; methods ; Terminology as Topic ; Translations

Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; drug therapy ; Humans ; Phytotherapy ; methods ; trends

Mutual promotion, mutual assistance and mutual inhibition are commonly for the compatibility of Chinese herbs, but they are also existed among the acupoints. In the paper, the relevant literature on acupoint, compatibility was collected and the mutual promotion, mutual assistance and mutual inhibition relationships of acupoints were described. The laws of the above mentioned combinations, the theoretic evidences and modern researches were summarized briefly. The mutual promotion and mutual assistance refer to the coordination of acupoints, presenting the relationship of the primary and the secondary about the mutual assistance. Hereby, the acupoints could be divided into the simple assistant acupoints and the acupoints from the affected meridians. The mutual inhibition is used to describe the antagonism effect in acupoint combination. There are more researches on the mutual promotion of acupoint combination but less ones on the mutual inhibition and its mechanism is just hypothetic. It is very important to have the deep study on those compatibility relationships for the improvement of acupuncture efficacy and to elaborate the effect mechanism.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians

Drug Compounding ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Terminology as Topic ; Translations

Objective To evaluate the therapeutic effect and safety of insulin lispro mix 50/50 combined with mefformin in newly diagnosed overweight/obese type 2 diabetic mellitus patients.Methods Sixty-two patients with newly diagnosed overweight/obsess type 2 diabetic mellitus were randomly divided into observation group (32 cases) and control group (30 cases) by systematic sampling method.The observation group received insulin lispro mix 50/50 combined with metformin,and the control group received recombinant human insulin and insulin glargine.The therapeutic effect and safety were compared between the 2 groups.Results There were no statistical differences in the blood glucose before eating,before retiring and at mane primo 3:00 between the 2 groups (P ＞ 0.05).There were no statistical differences in the time of blood glucose standard and rate of hypoglycaemia between the 2 groups (P ＞ 0.05).Daily insulin dosage and costs in the observation group were lower than those in the control group [(0.6 ± 0.1) U/kg vs.(0.8 ± 0.1) U/kg and (15.8 ±2.1) yuan/d vs.(21.3 ±2.6) yuan/d],and there were statistical differences (P ＜0.05).Conclusion Insulin lispro mix 50/50 combined with mefformin provides a convenient,effective and safe therapy for newly diagnosed overweight/obese type 2 diabetic mellitus patients and high cost performance.

Objective To explore the etiologies, clinic symptoms and the methods of emergency therapy for neonatal convulsion. Methods Eighty-four patients with convulsion in pediatric department in our hospital were reviewed,analysed and summarized their clinic informations,first-aid measures. Results The etiologies were HIE(hypoxia-ischemic encephalopathy)41 cases(48.8%),ICH(intracranial hemorrhage)16 cases(19.0%),and hypocalcemia 9 cases(10.7%),the quantity of these patients added up to 2/3 of all. Conclusion The primary measures to reducing incidence of the diease were as follows:do well health protection during perinatal period,treat betimes aiming at etiologies,prevent fleetly paroxysm of convulsion.

Objective To investigate the clinical characteristics,treatment options and prognosis of duplex kidneys in children.Methods Data were retrospectively collected from all patients who were hospitalized at Shengjing Hospital Affiliated to China Medical University from January 2008 to May 201 5.The surgery to retain moie-ty nephron was performed in 30 cases:1 2 cases underwent non common sheath ureter reimplantation,4 cases of the patients had common sheath ureter reimplantation,1 2 patients underwent transurethral resection of the cyst,1 case of them had pyeloureterostomy,and the other patients underwent lower -pole pyeloplasty.Removal of renal moiety was performed in 52 cases:43 patients underwent upper -pole heminephrectomy,8 patients underwent upper pole hemi-nephrectomy and lower -pole ureter reimplantation,and 1 case of the patients had upper -pole heminephrectomy and lower -pole ureteroplasty.Results A total of 54 cases were followed up,the follow -up rate reached 65.9%,the follow -up time lasting 2 months to 4 years,with an average time of 9.53 months.All clinical symptoms disappeared after remove moiety operation.There were small ureteral cysts but compared with the preoperative condition,the symp-toms reduced significantly in 4 cases.All clinical symptoms disappeared in patients whose nephron was retained after operation,and hydronephrosis was alleviated.De novo 2 degree of vesicoureteral reflux was found in 3 out of 1 2 pa-tients who underwent transurethral puncture of the cyst.Conclusions The clinical manifestations of duplex kidney have some characteristics which include recurrent urinary tract infection,normal intermittent voiding urine dripping, abdominal pain,urethral orifice mass,abdominal mass and aggravation of hydronephrosis.Duplex kidney is often asso-ciated with cardiac malformation and cryptorchidism.The preoperative testicular examination and echocardiography should be performed.The choice of operation depends on the clinical manifestation,auxiliary examination results and comprehensive analysis.The prognosis of duplex kidney is well,but patients need to be further followed up af-ter operation.