Objective:To investigate the role of clinical pharmacists in the therapy for a patient with acute promyelocytic leukemi-a. Methods:Clinical pharmacists participated in the treatment process of a patient with acute promyelocytic leukemia complicated with retinoic acid syndrome after tretinoin therapy. The rational treatment plan was put forward according to the literatures,the characteristics of drugs and the general situation of the patient. Results: Promising therapeutic effect was obtained,and the patient was discharged from the hospital. Conclusion:Clinical pharmacists play an active role in improving rational drug use and providing better individual-ized treatment for patients.

Objective To explore the roles of executive function deficits in adolescent violent behaviors. MethodsAccording to the findings of general state questionnaire,modified overt aggression scale and interview,93 male juvenile delinquents were randomly divided into violent antisocial group(n=47) and nonviolent antisocial group(n=46).Besides,50 male adolescents in vocational schools were served as normal controls.All the participants were subjected to Wechsler adult intelligence scale(WAIS) test,Wisconsin card sorting test(WCST),Stroop color-word test(CWT) and Tower of Hanoi(TOH) test. Results There was no significant difference in IQ between violent antisocial group and nonviolent antisocial group(P0.05).In CWT,violent antisocial group and nonviolent antisocial group had significant difference with normal control group in number of correct responses of Stroop interference effects(SIE)(P0.05).In TOH,the total time spent in violent antisocial group and nonviolent antisocial group was significantly longer than normal control group(P0.05). Conclusion There exists executive function deficits in male adolescents with unlawful acts,and violent behaviors may have a closer relationship with executive function deficits.

Objective To discussing the methods used in creating non linear developable biomechanical models of skeletal muscle.Methods One of the basic tools of the analytical approach in analytical mechanics, the principle of virtual work for deformable systems, was used to create the model. By means of method of Lagrange multipliers, the problems of constraints, such as the incompressibility of skeletal muscle, were effectively tackled. Results and Conclusion The biomechanical models of skeletal muscle has been developed. The program of this model can be used to obtain nodal displacement coordinates of given nodal coordinates and parameters.

The cancer stem cell hypothesis posits that cancer stem cells,which are rare among the tumor cell population and share many common properties with normal stem cells,and have been positively identified and successfully isolated from some cancers,are responsible for tumorigenesis and implicated in multistage cancer progression,particularly with respect to metastasis.A better understanding may provide insights into the development of cancer stem cell-targeting therapeutic strategies.The examines what is known regarding cancer stem cells' concept,comparison with normal stem cell,potential origins,assays for isolation and their roles in metastasis.

Objective: To detect the mRNA levels of AK097082 and BC031001 encoded by psiTPTE22 gene in order to determine whether psiTPTE22 gene is the microarray-detected over-expressed gene in colon cancer and explore the role of psiTPTE22 in carcinogenesis. Methods: RT-PCR and real-time fluorescence quantitative PCR were used to detect the transcription of AK097082 and BC031001 encoded by psiTPTE22 gene in kidney, liver, stomach, lung, and colon cancer tissues and adjacent normal tissues as well as nine cancer cell lines and placenta tissues. Results: RT-PCR showed that only the mRNA of BC031001 encoded by psiTPTE22 was expressed in colon tissues. Real-time quantitative PCR assay and F test confirmed that there was no significant difference between colon cancer and adjacent normal tissues (P > 0.05). So psiTPTE22 was not the specific up-regulated gene in colon cancer detected by microarray. Real-time quantitative PCR assays also confirmed that BC031001 was over-expressed in kidney, liver, stomach, and lung normal tissues but had low expression in corresponding cancer tissues. BC031001 had no expression or weak expression in several cancer cell lines but had relatively high expression in placenta tissues. F tests found that the difference was significant in the expression level of BC031001 between kidney, liver, stomach, and lung adjacent normal tissues and the corresponding cancer tissues (P < 0.05). Conclusions: The mRNA expression of BC031001 encoded by psiTPTE22 gene has negative correlation with several kinds of cancer. Further studies are needed to reveal the mechanism underlying its down-regulation and its role in a carcinogenesis.

Objective: To explore the molecular mechanism of the supplemented Naotaifang (sNTF) in the treatment of vascular dementia (VD), and the mRNA expression profiles of hippocampal tissue of VD model rats before and after the intervention of modified sNTF were investigated by microarray analysis. Methods: VD model was established by bilateral common carotid artery ligation. VD rats were treated with sNTF for 30 days. HE staining and Morris water maze were used to evaluate the therapeutic effect of sNTF. The mRNA expression profiles data of VD model rats before and after intervention of sNTF were obtained by Agilent mRNA expression chip. The significantly differentially expressed genes were screened by microarray analysis, and the protein-protein interaction (PPI) network was constructed. The biological processes and signaling pathways in which differentially expressed genes were mainly involved and analyzed by GO and pathway enrichment. Immunohistochemistry and qRT-PCR were used to verify the chip analysis results. Results: HE staining and Morris water maze experiments showed that VD rats showed cerebral ischemia, hippocampal neuron damage, and decreased spatial learning and memory function, but sNTF can partially reverse this trend. 469 differential expression genes were screened by microarray analysis, including 180 up-regulated genes and 289 down-regulated genes. IL6, FGF2, TNF, and IL1b may be the main pharmacodynamic targets of sNTF in the treatment of VD rats, and the results were verified by immunohistochemistry and qRT-PCR. GO and pathway enrichment analysis showed that these genes were closely related to biological processes such as inflammation and apoptosis, and these genes were mainly involved in the regulation of TNF signaling pathway, toll-like receptor signaling pathway and the apoptosis pathway. Conclusion: The results suggested that the therapeutic effect of DSS on AD involves multiple genes and pathways, and and inhibition of hippocampal neuroinflammation may be one of the important mechanisms of its anti-VD.

Objective: To investigate the willingness to pay integrated medical and elderly care services and identify the influencing factors among the elderly in Hohhot City, Inner Mongolia, so as to provide insights into promoting integrated medical and elderly care services. Methods: The elderly at ages of 60 years and older were sampled using a convenient sampling method from public venues in four districts of Huimin, Saihan, Yuquan and Xincheng in Hohhot City from June to December 2021. Basic characteristics, health and disease burdens, social support and willingness to pay integrated medical and elderly care services were collected, and factors affecting the willingness to pay integrated medical and elderly care services were identified among the elderly using a multiple linear regression model. Results: A total of 1 008 valid questionnaires were recovered, with an effective recovery rate of 96.74%. The respondents included 519 men (51.49%) and 489 women (48.51%), and had a mean age of (69.47±6.42) years. The monthly average fees of willingness to pay integrated medical and elderly care services were (2 076.49±36.79) Yuan, and there were 636 participants with 2 000 Yuan and less monthly average fees of willingness to pay integrated medical and elderly care services (63.10%). Multiple linear regression analysis showed that place of residence (β=180.832), satisfaction with housing (satisfied, β=-140.760), physical self-care ability (completely self-care: β=-238.244; mostly self-care: β=-254.557), burdens of disease diagnosis and treatment (able to afford: β=452.488; partly afford: β=228.626), monthly income (β=347.144), expenses of medications (β=0.019) and total score of social support (β=17.116) were factors affecting the willingness to pay integrated medical and elderly care services among the elderly. Conclusions The willingness to pay integrated medical and elderly care services among the elderly in Hohhot City is associated with place of residence, monthly income, satisfaction with housing, physical self-care ability, burden of disease diagnosis and treatment, expenses of medications and social support.

Objective To observe the clinical, neuropathogical, neurophysiological characteristics of Charcot-Marie-Tooth disease, type 1A (CMT1A) which was similar to chronic inflammatory demyelinating polyradiculoneuropathy(CIDP).Methods The clinical data, neuroelectrophysiological changes and pathological features of sural nerve biopsy were taken from 2 CMT1A patients who were proven to be 17p12 duplication with CIDP features, and analyzed comprehensively. Results Two CMT1A cases with classical chronic course showed both subacute course and clinical manifestations similar to CIDP, however, the changes of neuroelectrophysiology and pathological characteristics of the nerve biopsy in 2 cases were different from CIDP in some way. We confirmed the chronic inflammatory demyelinating type of the CMT1A patients whom the immunotherapy was effective on.Conclusion The classical CMT1A 17p12 duplication patients who obtained immunotherapy effects might resemble CIDP both in clinical course and manifestation.

Objective To assess the application value of MSCTU(multi-slice computed tomography) in upper urinary obstructive disorders. Methods MSCTU was performed in 38 patients with upper urinary obstructive patients, and we reconstituted all abscissa axis images with 3D-reconstitution technology according obstructive level to select suitable delay scan time and got CTU post-processing images. Results Among 38 patients with upper urinary tract disorders, 13 cases were urolithiasis, 5 cases congenital urinary malformations, 8 cases upper urinary tract Obstruction caused by urinary neoplasm, 5 cases were stricture of ureter caused by inflammation or tuberculosis, and 7 cases by non-uretery derived tumor. The most early of delay scan time were 8 minutes and the most late were 2 hours. Conclusion MSCTU gets advantages such as high speed scan, excellent discrimination, and aplenty post-process technique, and is of great value in application of upper urinary obstructive.

Biomechanical Phenomena ; Humans ; Lumbosacral Region ; physiology ; Male ; Occupational Health ; Wood ; Workplace