Asparaginase ; adverse effects ; Child ; Child, Preschool ; Desensitization, Immunologic ; Drug Hypersensitivity ; therapy ; Female ; Humans ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy

Objective:To improve diagnosis and therapy of pseudoaneurysm by retrospectively discussing and analyzing of patients with pseudoaneurysm.Methods:The curative effects in 30 patients with pseudoaneurysm from 2003 to 2006 treated in our department were retrospectively addictive drugs and iatrogenic false.Femoral artery were constantly injuryed position.30 clinical cases were treated by surgical operations.The surgical treatment methods included pseudoaneurysm resection and arterial ligation in 9 cases,arterial suture in 3 cases,pseudoaneurysm resection and arterial suture in 15 cases,pseudoaneurysm resection and artificial vascular or autogenous saphenous vein bypass grafting in 3 cases.Conclusion:Pseudoaneurysm could be successfully cured after accurate diagnosis and proper surgical therapy.

BACKGROUND: Previous research reveals that, the morphous, structure, physicochemical property and mechanical characteristics of matrix in buffalo cornu all contribute to the biomaterials in the field of orthopaedics.OBJECTIVE: To investigate the correlation between the duration of matrix in buffalo cornu soaked in 30% hydrogen peroxide and the antigenicity, the biomechanical intensity of matrix in buffalo cornu treated by deproteinization.DESIGN, TIME AND SETTING: Measurement experiments were performed in the Mechanics Laboratory, Kunming University of Science and Technology (Kunming, Yunnan, China) from February to March in 2000.MATERIALS: Buffalo was provided by Luxi Abattoir of Yunnan Province (China), and then processed into test pieces at a nominal thickness.METHODS: The metric test pieces were rinsed with distilled water and soaked by chloroform-methyl alcohol at a ratio of 1:1 for 48 hours, then in 30% hydrogen peroxide for 24 and 48 hours, which served as the experimental group. While those remaining untreated were taken as controls.MAIN OUTCOME MEASURES: The modulus of elasticity and compressive strength were measured by electric measurement method and direct pressurization method, respectively.RESULTS: The modulus of elasticity between the experimental group and the control group had no significant difference (P>0.05). The compressive strength in the control group was significantly higher than that in the experimental group (P<0.01), and there were no significant differences between the experimental group treated for 24 hours and the experimental group treated for 48 hours (P>0.05).CONCLUSION: Subsequent to soaking in 30% hydrogen peroxide for 48 hours, the matrix in buffalo cornu maintains better biomechanicai intensity.

Mutual promotion, mutual assistance and mutual inhibition are commonly for the compatibility of Chinese herbs, but they are also existed among the acupoints. In the paper, the relevant literature on acupoint, compatibility was collected and the mutual promotion, mutual assistance and mutual inhibition relationships of acupoints were described. The laws of the above mentioned combinations, the theoretic evidences and modern researches were summarized briefly. The mutual promotion and mutual assistance refer to the coordination of acupoints, presenting the relationship of the primary and the secondary about the mutual assistance. Hereby, the acupoints could be divided into the simple assistant acupoints and the acupoints from the affected meridians. The mutual inhibition is used to describe the antagonism effect in acupoint combination. There are more researches on the mutual promotion of acupoint combination but less ones on the mutual inhibition and its mechanism is just hypothetic. It is very important to have the deep study on those compatibility relationships for the improvement of acupuncture efficacy and to elaborate the effect mechanism.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians

Objective To investigate the effects of electro-acupuncture (EA) on remyelination after sciatic nerve was transected in rats, so as to explore the possible mechanism of EA in treatment of peripheral nerve injury. Methods After transection of rat's sciatic nerve, the nerve regeneration chamber was built,then the rats were given EA stimulation at frequencies of 5 Hz and 100 Hz, respectively, and Solochrome Cyanine staining, HE staining of nerve fibers, immunohistochemical staining and semi-quantitative image analysis technique were employed to observe the remyelination of the nerve fibers and S-100 protein expression of Schwann cells. Results EA could significantly promote remyelination of the nerve fibers, elevate S-100 protein expression of Schwann Cells in repairing process of transected sciatic nerve of rats. The therapeutic effect of 5 Hz EA group was better than that of 100 Hz EA group. Conclusion EA is an effective way for the treatment of peripheral nerve injury. It can promote proliferation of Schwann cells and nerve fiber myelination. The therapeutic effects of EA are frequency-depondent.

Objective To explore the expression of drug transporter organic anion transporting polypeptide2(Oatp2) and P-glycoprotein(P-gp) in brains of chronic epileptic rats induced by lithium-pilocarpine.Methods Chronic epilepsy modles were elicited after status epilepticus(SE) induced by lithium-pilocarpine in adult Wistar rats.The expressions of Oatp2 and P-gp were detected by immuno-histochemistry(SABC) method.Results Positive expression of Oatp2 was predominantly in the plexus epithelial cells and(blood-brain) barrier endothelial cells.Weak staining for Oatp2 was also detected in the neurocyte.In contrast,apparent expression of(P-gp) was seen in brain capillary and neurocyte only.Compared with normal control rats,expression of Oatp2 on the plexus epithelial cells and brain capillary in chronic epileptic rats was significantly decreased(P

Selective serotonin reuptake inhibitors (SSRIs),a new generation of anti-depressant agent,are mainly used to treat emotional disorders in clinical practice now.Recent studies have found that SSRIs can increase neurogenesis after cerebral ischemia,promote neurovascular reconstruction,and are conducive to the recovery of neurological function.Furthermore,SSRIs can improve the tolerance of ischemic tissue,exert anti-inflammation and anti-oxidation properties,reduce the blood-brain-barrier injury,and inhibit excitatory amino acid toxicity in order to exert neuroprotective effect.This article reviews the related research progress in SSRIs and ischemic stroke.

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OBJECTIVE:To determine the content of ?9-tetrahydrocannabinol (THC) in hemp by GC-MS. METHODS: HP-5 quartz capillary column was used. The temperature programming was as follows: the initial temperature was kept at 200 ℃ for 1 min, then raised to 270 ℃ at the rate of 3 ℃?min-1 and kept for 10 min; the injector temperature was 280 ℃and the detector temperature was 290 ℃. RESULTS: The good linearity between peak area and concentration was obtained over the range of 5.0 ～45.0 ?g?mL-1 (r=0.998 7). The lowest detectable limit was 1.0 ?g?mL-1(S/N=5).The average recovery rate was 81.1% (RSD=3.8%,n=9). CONCLUSION: The procedure is simple, accurate and reproducible, and suitable for the quality control of hemp preparation.

OBJECTIVE:To study the quantitative structure-activity relationship of quinolones compounds by neural network(NN)method.METHODS:A3-layered BP neural network was constructed with the Matlab software package,the collected data were calculated,result of which was compared with that of the linear regression.RESULTS:Sum of square of errors for the neural network method was0.3042,which was less than that of linear regression;the predicted correlation co-efficient was0.86.CONCLUSION:The neural network method has achieved more precise fitting results than the linear re-gression in the study of the quantitative structure-activity relationship of quinolones compounds.