Reading therapy in hospital libraries, academic libraries and public libraries was described in terms of its theoretical study and practical study,and its significance in hospital library was elaborated by comparative analysis.

Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.

The WeChat service provided at present in 14 hospitals directly under the Yunnan Health and Family Planning Commission was surveyed with suggestions proposed for providing active Wechat service in hospitals in order to alleviate the difficulty to see a doctor and the tense relationship between doctors and patients.

Orthodontic tooth movement (OTM) is a very complicate mechano-biological procedure which is accomplished by the remodeling of periodontal tissues via orthodontic force.As the connective tissue between alveolar bone and cementum,periodontal ligament plays a vital role in the response and conduction of orthodontic force.The susceptible response of periodontal ligament to orthodontic force during OTM is a critical factor on inducing and modulating periodontal tissue restitution.This article reviews the concrete role of periodontal ligament and its mechano-biological behavior during OTM,discusses its mechanical response and biological mechanism respectively on histological,cellular and moleucular levels.

Objective:To investigate the clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema and evaluate the safety .Methods:Totally 96 cases of infantile with external ear eczema were ran-domly divided into the observation group (n=48) and the control group (n=48) according to a random number table .Both groups were given the conventional treatment .The control group was treated with topical compositus mentholi cream , while the observation group was treated with loratadine additionally .Both groups were treated for 10 d.The clinical efficacy , the level changes of interleukin-4 (IL-4), interferon-γ(IFN-γ) and immunoglobulin-E (IgE) before and after the treatment, the incidence of adverse reactions during the treatment and the relapse after 6-month follow-up were compared between the groups .Results:The total effective rate of the obser-vation group (95.83%) was significantly higher than that of the control group (79.17%, P<0.05); the levels of IL-4, IFN-γand IgE in both groups were significantly decreased after the treatment (P<0.05), and those in the observation group were significantly lower than those in the control group (P<0.05);there was no significant difference in the incidence of adverse reactions between the groups (P<0.05); the recurrence rate in the observation group (8.33%) was significantly lower than that in the control group (22.92%, P<0.05).Conclusion:The clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema is reliable with promising safety .

Objective To understand cerebral edema and development procedure of different time windows.Methods To analyze their prognosis through image document and operation findings of 52 cerebral trauma patients which were confirmed cerebral edema by CT and operation.Results he light cerebral oedema patients have a better prognosis,10 patients died and 1 patient became a plant man in 11 malignant brain dilatation patients.Conclusion The infernal circle of high brain pressure-cerebral ischemia,cerebral anoxia-cerebral edema result in cerebral edema-brain dilatation-malignant brain dilatation after cerebral trauma which leads to unremitting aggravated pathogenefic condition.So effective means should be used to interrupt the unremitting heightening ICP.

Objective To investigate the preventive application of octreotide acetate for the prevention of complications and serum pancreatic amylase secrection after pancreatoduodenectomy(PD).Methods Fiftysix cases who underwent PD in our hospital were randomized into the observational group (n =28) and the control group (n =28).The control group received routine preoperative treatment including fasting,gastrointestinal decompression,nutritional support,maintenance of water,electrolyte balance and the use of antibiotics,postoperative routine parenteral nutrition and antibiotic therapy.In addition to the conventional treatment,the observational group received prophylactic application of octreotide acetate by subcutaneous injection of 0.1 mg each time,3 times a day,and 7 days for a cycle of treatment.Blood biochemical index and postoperative complications in the two groups were monitored.Results The serum amylase levels in the observational group and the control group were (304.63 ±62.21) U/L and (445.52 ±64.52) U/L respectively at the tenth day after treatment.The two groups are significantly different in the serum amylase level (t =2.243,P ＜ 0.05).The pancreatic juice,gastric juice and bile drainage of patients in the observational group and the control group were (46.83 ± 31.42) ml,(189.92 ± 59.64) ml,(178.94 ± 45.18) ml,and (69.84 ± 34.30)ml,(237.08 ±71.27) ml,(356.11 ±64.23) ml respectively.The observational group had significantly reduced digestive fluid drainage volume compared with the control group (t =3.219,2.276,4.618 respectively,P ＜0.05).Complications occurred in 3 patients of the observational group (including 1 case of pancreatic fistula,1 case of hemorrhage,and 1 case of gastric emptying delay),with an incidence of 10.71％ (3/28).Complications occurred in 12 cases of the control group (including 3 cases of pancreatic fistula,2 cases of hemorrhage,3 cases of bile leakage,2 cases of delayed gastric emptying,2 cases of peritoneal infection),with an incidence of 42.86％ (12/28).There was significant difference between two groups in the incidence of complications (x2 =4.293,P ＜ 0.05).Conclusion Prophylactic application of somatostatin in PD restrains the secretion of digestive juice,and plays a preventive role for postoperative complications.The routine prophylactic application of octreotide in PD is necessary.

ObjectiveTo explore the effect of different nursing models to improve the quality of sleep for elderly patients in department of cardiology.Methods240 cases of patients in department of cardiology in our hospital were randomly divided into the control group and the observation group with 120 patients in each group.The control group was given conventional medical care and the sleep-related health education.While the observation group was given the targeted intervention measures based on the control group,including the provision of good psychological care measures to ensure a good sleep environment,arrange a reasonable sleep time,increase bedtime benign behavior and scientific education of hypnotic drugs knowledge.The PSQI score and sleep quality of different time points were compared.ResultsThe PSQI score of the observation group 1 week and 2 weeks after admission was significantly decreased compared with that upon admission,and was better than those of the control group.The PSQI score of the control group 2 weeks after admission had a marked decline,but the PSQI score 1 week after admission showed no significant difference.In the aspect of sleep quality,the rate of good sleep quality for the observation group 1 week and 2 weeks after admission increased significantly compared with that upon admission.The rate of the quality of good sleep 2 weeks after admission for the control group improved significantly than admission.The rate of promotion for the observation group was obviously better than that of the control group.ConclusionsThe targeted quality of sleep and psychological care interventions for elderly patients in department of cardiology can significantly improve the sleep quality in patients after admission,and enhance their confidence in overcoming the disease,thus contribute to disease treatment and rehabilitation.

Objective To investigate the clinical effect of integrated care model in improving the quality of life and enthusiasm of treatment in patients with cardiovascular diseases. Methods 60 patients in department of cardiology adopting integrated care from September 2008 to April 2011 were chosen as the observation group.60 patients with ordinary care were set as the control group.The quality of life and the situation for enthusiasm of treatment were taken for statistical analysis. Results Patients with good quality of life in the observation group was 39 cases (65.00％),more than 21 cases (35.00％) in the control group.Patients obtaining effective treatment result in the observation group was 48 cases (80.00％) and 15 cases (25.00％) in the control group,there was significant difference.It was statistical significant.Adherence to medication,reasonable diet,adequate exercise and proper understanding of disease status in the observation group were significantly better than the control group. Conclusions Application of integrated care models in nursing of disease and life of patients with cardiovascular diseases can improve the quality of life and enthusiasm of treatment of patients,which is better than general model of care.

There are multiple genes involved in the progress of evolution in breast cancer.Recent study showed that Twist gene may play key role in promoting tumor growth,invasion and metastasis through the epithelial-mesenchymal transition (EMT).Other studies also demonstrated that Twist gene expression maybe associated with patient outcomes and guiding clinical tailored therapies.