Reading therapy in hospital libraries, academic libraries and public libraries was described in terms of its theoretical study and practical study,and its significance in hospital library was elaborated by comparative analysis.

The WeChat service provided at present in 14 hospitals directly under the Yunnan Health and Family Planning Commission was surveyed with suggestions proposed for providing active Wechat service in hospitals in order to alleviate the difficulty to see a doctor and the tense relationship between doctors and patients.

Objective:To investigate the clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema and evaluate the safety .Methods:Totally 96 cases of infantile with external ear eczema were ran-domly divided into the observation group (n=48) and the control group (n=48) according to a random number table .Both groups were given the conventional treatment .The control group was treated with topical compositus mentholi cream , while the observation group was treated with loratadine additionally .Both groups were treated for 10 d.The clinical efficacy , the level changes of interleukin-4 (IL-4), interferon-γ(IFN-γ) and immunoglobulin-E (IgE) before and after the treatment, the incidence of adverse reactions during the treatment and the relapse after 6-month follow-up were compared between the groups .Results:The total effective rate of the obser-vation group (95.83%) was significantly higher than that of the control group (79.17%, P<0.05); the levels of IL-4, IFN-γand IgE in both groups were significantly decreased after the treatment (P<0.05), and those in the observation group were significantly lower than those in the control group (P<0.05);there was no significant difference in the incidence of adverse reactions between the groups (P<0.05); the recurrence rate in the observation group (8.33%) was significantly lower than that in the control group (22.92%, P<0.05).Conclusion:The clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema is reliable with promising safety .

Orthodontic tooth movement (OTM) is a very complicate mechano-biological procedure which is accomplished by the remodeling of periodontal tissues via orthodontic force.As the connective tissue between alveolar bone and cementum,periodontal ligament plays a vital role in the response and conduction of orthodontic force.The susceptible response of periodontal ligament to orthodontic force during OTM is a critical factor on inducing and modulating periodontal tissue restitution.This article reviews the concrete role of periodontal ligament and its mechano-biological behavior during OTM,discusses its mechanical response and biological mechanism respectively on histological,cellular and moleucular levels.

Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.

Since cancer-related pain is the worldwide problem,intrathecal drug delivery system (IDD)has been an effective pain management option for patients with chronic and cancer pain.Compared with the other ways,such as oral or intravenous infusion,the delivery of drugs into the intrathecal space provides superior analgesia with lower doses of analgesics to minimize side effects while significantly improve quality of life.Recently,besides traditional opioid (especially mainly morphine) for intrathecal,clinical experts have also found some other drugs could be used for IDD to control the cancer-related pain,and have observed their effect and related adverses.This article aims to provide a general overview of the development trend in this field.

Objective To explore the effect of pregnancy outcome with cervical cold knife conization in pa -tients with early stage cervical cancer .Methods 23 patients with cold knife conization and 21 patients with radical trachelectomy were collected .The pregnancy outcome and perinatal infants between the two groups were compared . Results The pregnancy rate was 82.6%in the observation group,71.4%in the control group,there was statistically significant difference(χ2 =8.654,P=0.002);the section rate was 37.5% in the observation group,30.8% in the control group,there was statistically significant difference (χ2 =9.645, P =0.000 );10 cases of term delivery (62.5%)and birth weight was(3.27 ±1.15)in the observation group,term delivery(69.2%)and birth weight was (2.81 ±0.96)in the control group,proportion and birth weight were statistically significant differences (χ2 =11.671, P=0.000)(t =9.683,P=0.000);there were statistical significance in the outcome of pregnancy (Fisher P=0.036)and perinatal infants(Fisher P=0.034)among patients with different cervical conization height;the relapse rate was 4.4% in observation group,9.5% in the control group,the relapse rate of the two groups had significant difference(Fisher P =0.039).Conclusion Compared with radical trachelectomy ,patients treated by cold knife conization has high pregnancy rate and high cesarean section rate ,which can influence the outcome of pregnancy and perinatal infants .

Objective To investigate the preventive application of octreotide acetate for the prevention of complications and serum pancreatic amylase secrection after pancreatoduodenectomy(PD).Methods Fiftysix cases who underwent PD in our hospital were randomized into the observational group (n =28) and the control group (n =28).The control group received routine preoperative treatment including fasting,gastrointestinal decompression,nutritional support,maintenance of water,electrolyte balance and the use of antibiotics,postoperative routine parenteral nutrition and antibiotic therapy.In addition to the conventional treatment,the observational group received prophylactic application of octreotide acetate by subcutaneous injection of 0.1 mg each time,3 times a day,and 7 days for a cycle of treatment.Blood biochemical index and postoperative complications in the two groups were monitored.Results The serum amylase levels in the observational group and the control group were (304.63 ±62.21) U/L and (445.52 ±64.52) U/L respectively at the tenth day after treatment.The two groups are significantly different in the serum amylase level (t =2.243,P ＜ 0.05).The pancreatic juice,gastric juice and bile drainage of patients in the observational group and the control group were (46.83 ± 31.42) ml,(189.92 ± 59.64) ml,(178.94 ± 45.18) ml,and (69.84 ± 34.30)ml,(237.08 ±71.27) ml,(356.11 ±64.23) ml respectively.The observational group had significantly reduced digestive fluid drainage volume compared with the control group (t =3.219,2.276,4.618 respectively,P ＜0.05).Complications occurred in 3 patients of the observational group (including 1 case of pancreatic fistula,1 case of hemorrhage,and 1 case of gastric emptying delay),with an incidence of 10.71％ (3/28).Complications occurred in 12 cases of the control group (including 3 cases of pancreatic fistula,2 cases of hemorrhage,3 cases of bile leakage,2 cases of delayed gastric emptying,2 cases of peritoneal infection),with an incidence of 42.86％ (12/28).There was significant difference between two groups in the incidence of complications (x2 =4.293,P ＜ 0.05).Conclusion Prophylactic application of somatostatin in PD restrains the secretion of digestive juice,and plays a preventive role for postoperative complications.The routine prophylactic application of octreotide in PD is necessary.

Objective To study the correlation of blood uric acid,lipoprotein associated phospholipase A2(Lp-PLA2) and arterial stiffness in young patients with coronary heart disease.Methods 56 young patients with coronary heart disease were selected as the observation group,50 young healthy subjects were selected as control group.The serum uric acid,Lp-PLA2 and arterial stiffness in the two groups were determined.Blood uric acid,Lp-PLA2 and arterial stiffness in patients with coronary heart disease were analyzed.Results There were no significant differences in age,sex,BMI,systolic blood pressure,diastolic blood pressure and triglyceride between the two groups (all P>0.05).The total cholesterol,low density lipoprotein,uric acid and Lp-PLA2 in the observation group were significantly higher than those in the control group (t=3.927 4,4.162 4,5.772 6,9.770 1,P<0.05,P<0.01).High density lipoprotein in the observation group was significantly lower than that in the control group (t=2.6043,P<0.05).Multivariate Logistic regression analysis showed that low density lipoprotein cholesterol,uric acid,Lp-PLA2 were independent risk factors for coronary heart disease (low density lipoprotein uric acid OR=1.053,95% CI:1.031-1.106;uric acid OR=1.082,95% CI:1.043-1.115;Lp-PLA2 OR=1.007,95% CI:1.002-1.011).The arterial stiffness of the observation group was (8.86±1.63)v·cm-1·s-1,and had positive correlation with serum uric acid (r=0.221,P<0.05) and Lp-PLA2 (r=0.361,P<0.05).Conclusion Blood uric acid,Lp-PLA2 can reflect the early arterial stiffness in young patients with coronary heart disease.

This article studies the choice of apology strategy among Chinese and American undergraduates from the perspective of cultural analysis.