1.Glucose fluctuation and intervention in its clinical significance
Journal of Medical Postgraduates 2003;0(07):-
The initiation and development of diabetic chronic complications is associated not only with the level of blood glucose,but also with the glucose fluctuation.The damage in large artery and microvessel may be caused by glucose fluctuation.There are two causes which induce glucose fluctuation in clinical:one is postprandial hyperglyceamia with not well controlled,the other is hypoglycemia causes by unsuitable therapy.A lot of effective new types of substances were applicated in clinical,such as ?-glucosidase inhibitor,glinide-insulin secretagogus,fast-acting and long-acting insulin analogues.With these new powerful tools,there is possibility to treat diabetes more correctly and safely,and control the blood glucose in a stable and good level.
2.Expression and location of IL-2/IFN-? fusion protein in colorectal tumor cell lines
Chinese Journal of Practical Internal Medicine 2006;0(18):-
Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.
3.Advances in protein energy malnutrition in patients with chronic kidney disease
Chinese Journal of Clinical Nutrition 2013;21(1):30-34
The incidence of malnutrition among patients with chronic kidney disease (CKD) constantly increases despite the development of health care and dialysis techniques.New nutritional targets for CKD patients upon maintenance treatment have been developed.Before dialysis,evidences have shown that a long-term nutritional care plan,with a control of protein intake,can effectively correct metabolic disorders including proteinuria and acidosis.During the maintenance dialysis,the optimal protein and energy intakes have been recently challenged.The new classification of nutritional disorders in CKD patients may help the easily identification of protein-energy wasting.
7.A way to strengthen cohesion of an English class Community - Language Learning
Journal of Chongqing Medical University 2000;25(z1):123-124
Community Language Learning was employed to strengthen English class cohesion and improve students performance, and positive results have been achieved with regard to classroom atmosphere, students involvement and CET-4 scores. Initial studies and experiments show that application of foreign linguistic teaching theories in the Chinese setting is feasible and rewarding.
8.Stem cells in cartilage tissue engineering and influential factors
Chinese Journal of Tissue Engineering Research 2013;(46):8116-8121
BACKGROUND:A variety of stem cells as seed cells for cartilage tissue engineering have been extensively studied.
OBJECTIVE:To analyze the biological characteristics of different kinds of stem cells and their application in cartilage tissue engineering.
METHODS:By retrieving recent studies on sources of stem cells and influential factors in cartilage tissue engineering, the authors focused on optimization of harvesting stem cells from different sources in bone tissue engineering, problems, and factors that affect cellgrowth, differentiation, reproduction and metabolism, which provide a theoretical basis for tissue-engineered cartilage repair.
RESULTS AND CONCLUSION:A large number of experimental studies have confirmed that exogenous stem cells can be used as seed cells for cartilage tissue engineering. Influential factors relative to cartilage tissue engineering construction using seed cells include growth factors, cellscaffold, cellseeding density, oxygen concentration, stress and micro-gravity. However, tissue-engineered cartilage is stil in the stage of laboratory research, and stem cells for cartilage tissue engineering involves many issues, such as stem celltransformation, in vitro culture of stem cells, how to prolong the survival of cells, reduce cellantigenicity and enhance the host’s immune tolerance, which are yet to be resolved.
9.Principles of selecting words and making sentences in medical English writing
Chinese Journal of Medical Education Research 2012;11(7):750-753
Medical English writing presents specific principles of selecting words and making sentences.Word selecting requires brevity,necessity,and clarity,while sentence making demands proper length,expressive verb,and impressive subject.Understanding these principles is of great help to Chinese medical writers.
10.Etiology of narcolepsy:a review of the literature
International Journal of Pediatrics 2013;(3):227-230
Narcolepsy is a disabling sleep disorder characterized mainly by irresistible excessive daytime sleepiness.It seriously influences patient's academic,family,and social function.The etiology of narcolepsy is still elusive,but the hereditary and environmental factors have been suggested to contribute the most.It is a multi-gene regulation disease,the researches of Human Leucocyte Antigen(HLA) gene type HLA-DQB1 * 0602 and HLA-DRB1 * 1501 are most popular in recent years.Especially the HLA-DQB1 * 0602 is regard as the major HLA susceptibility allele for narcolepsy almost in all ethnic groups.And the hypocretin excreting neurons and the hypocretin's deficits would directly lead to somnolence.Some environmental factors which are newly found these years are still playing important roles,such as the contact with certain antigens,infection of beta hemolytic streptococcus,passive smoking and so on.