Aim To observe the fluctuation of uric acid in serum after replicating rat hyperuricemia model with hypoxanthine、uricase inhibitor combined,and to discuss the method of continuity hyperuricemia replication on rats. Method Hypoxanthine was administered via stomach or bait vessel,uricase inhibitor was injected subcutaneouslly,then the relative biochemical indicators of rats were inspected respectively at different periods of time after replicating the model. Results When hypoxanthine(50 g HX?kg-1bait vessel or 100 g HX?kg-1bait vessel) was administered via bait vessel,uricase inhibitor(200mg?kg-1) was injected subcutaneouslly,the uric acid in serum of different groups were much higher than control group(P

0.05), but both of them were significantly lower than those of gliomas (t=3.05 and 3.37, P

Alport syndrome is a hereditary glomerular basement membrane disease.Hematuria,sensorineural deafness and progressive renal function impairment is the main clinical symptoms.Alport syndrome can be associated with ocular abnormalities,and a few of patients were complicated with diffuse leiomyoma.The incidence of Alport syndrome with diffuse leiomyoma is low,and it mainly invades esophagus,the trachea and female genital tract,et al.Patients with Alport syndrome and diffuse leiomyoma have difficulty in swallowing and postprandial vomiting,recurrent bronchitis symptoms and dyspnea.Diffuse leiomyoma is commonly seen in the esophagus.Alport syndrome with huge esophageal and gastric leiomyoma is rarely seen in clinical practice.In this article,the imaging manifestations of Alport syndrome combined with huge esophageal and gastric leiomyoma is summarized to improve the understanding and diagnostic accuracy of this disease.

Objective To study the relationship between uterine receptivity and estrogen receptor, progesterone receptor on endometrial epithelial cells of LPD. Methods Integrinβ3 subunit, ER,PR on endometrial epithelial cells of LPD swere datermined by immunmohisto chemical analysis. Results Integ rin β3 subunit was significantly decreased, while estrogen receptor and progesterone receptor were significantly elevated in glandular epithelial cells from tissue samples with LPD. Concluslon Uterine receptivity is decreasedin women with LPD, which is closely assosciated with failure of ER、PR downregulation in middle luteal phase.

Objective To study the clinical effect of parecoxib sodium for injection combined with psychological intervention on postoperative analgesia in the patients with thyroid cancer. Methods 100 patients with thyroid cancer Hangzhou tumor hospitalfrom July 2015 to April 2017 were randomly divided into two groups, the experimental group and the control group. The control group were given parecoxib sodium for injection, and the experimental group were received parecoxib sodium for injection combined with psychological intervention. Three days after treatment, the average amount of parecoxib sodium for injection and SAS, SDS score in the two groups were compared. Results The average dosage of parecoxib sodium for injection in the experimental group was (45.6±9.7) mg, and (67.9±9.5) mg in the control group. In the control group, SAS was (45.88± 7.56)points before treatment and (50.42±7.91) points after treatment, SAS was (45.94±7.32)points before treatment and (40.81 ± 6.61) points after treatment. SDS in the control group before treatment was (45.53±8.62) points and (50.29±7.24) points after treatment. In the experimental group, SDS before treatment was (45.41±7.18) points and (40.36±6.15) after treatment. The differences of all the data were statistically significant in the two gorups(P<0.01). Conclusion Postoperative psychological intervention can effectively enhance the analgesic effect of parecoxib sodium for injection, reduce the dosage and also improve the psychological score. This treatment is worthy of clinical promotion.

This article is to report the result and experience of the clinical application of the extraluminal circumferential-suture ligation to close the bronchial stumps after pulmonary resections. This method was used for 469 times in 400 patients with various diseases including tuberculosis, lung cancer, and chronic suppurative disease with excellent results. After the use of this method, the incidence of the dreadful postoperative complication of broncho-pleural fistula was reduced to only 0.25%, and it never occurred when a main or a large bronchus was involved.It is pointed out that the advantage of this extraluminal circumferential-suture ligation method cannot be overemphasized and its success lies on two crucial steps as follows:1. The traditional open method to divide a bronchus is substituted with the new close method, which can avoid spraying the highly infectious bronchial contents into the pleural cavity to cause contamination. Thus the main source of infection is cut off.2. Every stitch of the circumferential suture is done extraluminally without penetrating the whole thickness of the bronchial wall or entering the infections bronchial lumen, which will further minimize the chance of infection.

It is well known that pulmonary hypertension(PH) is one severe complication of bron-chopulmonary dysplasia( BPD) that is associated with high mortality. Aberrant pulmonary vascular growth, abnormal vasoreactivity and pulmonary vascular remodeling may ultimately lead to PH. Symptoms of PH of-ten overlap those of BPD itself. Furthermore,the emergence of symptoms may indicate that the disease has already progressed to a late, less reversible phase, thereby supporting arguments for screening all infants at risk. Echocardiography is non-invasive and widely available,and is currently the most commonly used screen-ing modality for PH in infants with BPD. Because the incidence of associated cardiovascular anomalies is high,cardiac catheterization and CT scanning of the chest should be considered in all infants who have signifi-cant PH despite optimal management of their lung disease. Early diagnosis and aggressive specific drug thera-py can improve the outcome for these patients.

The data of autism in online question and answer communities of Zhidao.baidu.com and Yahoo!Answers were analyzed, which showed that the understanding of online question and answer communities users in China and USA was quite different.The users in USA mastered the basic knowledge of diseases much better than those in China and more detailed questions were asked by users in USA than by those in China.The clarity, completeness, accuracy and operability are the most important factors for selection of answers.Autism and its countermeasures have been well and widely accepted in American society.