The angiotensin converting enzyme (ACE) gene is one of the main candidate genes of the genetic predisposition study of stroke,however,the correlation between the ACE gene polymorphism and stroke remains controversial.This article reviews the advances in research on the correlation between the ACE gene polymorphism and stroke in recent years.

Humans ; Ischemia ; metabolism ; pathology ; therapy ; Ischemic Postconditioning ; methods ; Myocardial Reperfusion Injury ; metabolism ; pathology ; therapy

Objective To explore the clinical feature,treatment and prognosis of neonatal small intestinal atresia.Methods Retrospective study was carried out of 80 neonatal small intestinal atresias over the last 14 years,including diagnosis,treatment and prognosis.Results Of them,62 cases were healed(77.5%),18 cases were dead(22.5%),24 cases(30%)associated with other anomalities.The living cases were followed up for 6 months to 3 years.These symptoms had not relapse.Conclusions Satisfactry effect can be obtained by early diagnosis and operative treatment.Sonography is an ideal way for early finding intestinal atresias in a fetus.End-to-end single layer anastomosis is an ideal way for monointestinal atresia,and poly-end-to-end single layer anastomosis plus long gastrointestinal silicone tube for supporting is an ideal way for multipal intestinal atresia.

Objective To establish a model of bone cancer pain in rats and to evaluate the role of voltage gated sodium channel Nav1.8 in the course of bone cancer pain by observing the expression of Nav1.8 in dorsal root ganglion in the model with bone cancer pain.Method Female SD rats received intra-tibial injection of syngenetic Walker256 mammary gland carcinoma cells in different concertration(103/?l,104/?l or 105/?l).Pain threshold of mechanical hyperalgesia and thermal hyperalgesia were tested at 1d,3d,5d,7d,10d,and 14d after cell injection.The development of the bone tumor was verified by pathological examination 14d after cell injection.The L5-6 DRG was obtained from normal rats and rats with bone cancer pain.Expression of voltage gated sodium channel Nav1.8 was investigated by RT-PCR.Result Intra-tibial injection of Walker256 cells produced a rapidly expanding tumor within the boundaries of the tibia,causing marked remodeling of the bone.Rats receiving intra-tibial injection of Walker256 cells displayed gradual development of both mechanical and thermal hyperalgesia 7-14 days after the injection.The expression of Nav1.8 in DRG was up-regulated in the model of bone cancer pain in rats(P

ObjectiveTo assess the value of stent-assisted angiopl asty in the treatment of extracranial carotid stenosis.Methods A total o f 164 cases of ex tracranial carotid stenosis from October 2000 to December 2002, including 146 ca ses of carotid bifurcation stenosis, 13 cases of extracranial internal carotid s tenosis, and 5 cases of common carotid stenosis, were treated by self-expandable stent placement and angioplasty.ResultsStent placement and angioplasty was successfully accomplished in all the 164 patients. The degree of stenosis was re duced from (78 8?13 6)% before the treatment to (10 2?7 5)% after the oper atio n. There were 1 case of transient ischemic attack (TIA) (0 6%) and 1 case of mi n or stroke (0 6%) during the peri-operative period, but no death or major stroke took place. Follow-up for 3～30 months (mean, 8 9 months) in 145 cases found no T IA, cerebral apoplexy or death. Forty-five patients were followed by digital sub traction angiography (DSA) 6 months after the treatment, and asymptomatic re-ste nosis occurred in 1 case (2 2%).ConclusionsEndovascular ste nt-assisted angio plasty for extracranial stenosis is safe and effective, with favorable short-ter m outcomes.

Objective To analyze the causes, prevention and treatment of repture druing procedure for intracranial aneurysm embolization with GDC.Methods All the seven patients were embolized. Six patients were ruptured during the procedure and continuously embolized until the bleeding was halted. Another one was identified by post procedure CT. Results Four patients recovered unevent fully with one only suffering from mild deficit. Another 2 patients died of hyper intracranial pressure within one week. Conclusions Rupture during procedure of intracranial aneurysm embolization with GDC may be related to manipulation, properties of the parent artery and arneurysm. Continuous embolization with GDC will provide favorable prognosis for the patients.

Objective To evaluate the endovascular embolization treatment of large and giant ophthalmic aneurysms. Methods Three aneurysms were embolized with coils only and 5 aneurysms were treated with stent placement togather with subsequent coiling. Results In the 3 aneurysms treated only with GDC, total embolization was achieved in 1 and partial embolization in 2. In the stent placement and coiling case, 4 aneurysms were densely packed and another one was partially packed. Conclusions Combined stenting and coiling is effective and safe for the treatment of large and giant ophthalmic artery aneurysm with the preservation of parent artery.

Objective To evaluate the safety and short term outcome of stent assisted angioplasty for extracranial carotid stenosis. Methods From October 2000 to September 2002, 93 cases of extracranial carotid stenosis, including 86 cases of carotid bifurcation stenoses, 4 of extracranial internal carotid stenoses, 2 of common carotid stenoses and 1 of functional external carotid stenosis, were treated by self expandable stent placement and angioplasty. Results Stent placement and angioplasty were successfully administered in all the 93 patients. The average stenosis rate was reduced from (79.5?14.6)% before treatment to (11.2?7.8)% after stent assisted angioplasty. There were only 1 case of TIA (1.1%) and 1 case of minor stroke (1.1%) during the operation, without mortality or major stroke. No cerebral ischemic attach occurred in the 91 patients during clinical follow up for a period of 3 25 months with an average of 7.9 months. Twenty nine patients were angiographically followed up 6 months after treatment with only one asymptomatic restenosis (3.4%). Conclusions Endovascular stent assisted angioplasty for extracranial stenosis is safe and effective with considerable good short term outcome.

Objective To report experience of endovascular stenting combined with coiling for intracranial wide necked aneurysms and to investigate its indication, technical tip, prevention and treatment of complication, safety and efficacy. Methods The coronary stents were implanted across the neck of intracranial wide necked aneurysms in 105 patients (78 located in anterior circulation and 27 in posterior circulation). Microcatheters were introduced into the aneurysm sac through stent mesh. GDCs were used to embolize the aneurysms . Results The stents were deployed in 104 patients and total occlusion was obtained in 80 cases and more than 90% in 24 cases. The patients recovered well with patency of the parent arteries except one with cerebral infarction and another with carotid dissection during the procedure. The stent collapsed in one case after coiling.No re bleeding or symptom related to thrombosis occurred during clinical follow up for 3 28 months. Follow up angiogram in 62 cases showed no recanalization in all patients, but two with further thrombosis and one with mild stenosis in proximal segment of the stent. Conclusions Endovascular therapy combined stent implantation and microcoil placement would be a valid alteration for the treatment of complicated intracranial aneurysms. However, long term outcome need further study.

90%) and partial in 46 (