It is discussed in this paper the origins and pathogenesis of treating senile disease from spleen in TCM,and the relationship between various methods of invigorating the spleen and senile deficiency syndromes.It has been proposed that the therapy principles of invigorating qi and spleen,stimulating the appetite to awake the splee,primering blood to go back to the spleen,dehumidification to activate spleen-energy,warming the kidney and spleen,dispersing the depressed liver-energy to belifit the spleen,going on dieting to belifit the spleen and clearing away heart-fire to support spleen etc.are used to prevent and cure senile diseases.It also listed the corresponding treatment prescriptions for the elderly patients.It provides a theoretical basis for treatment of senile diseases from the governance of spleen.And it provided a realistic basis and the implementation of the method for the prevention and treatment of elderly patient's deficiency aging.

Objective To investigate the relations between radiological findings and pathological classification of superficial depressed(Ⅱc type)early gastric cancer.Methods Radiological features in subtonic double contrast barium examination and the endoscopic pictures of early gastric cancer compared with the global pathological specimens and micro-pathological features were prospectively studied.Combined with the gastric endoscopic pictures,the sharpness of margin of the lesions,the changes of converging mucosal folds and the changes of the depressed surface on the film of double contrast barium examination were analyzed.The correlation between the radiological features and histological classification of gastric cancer including well differentiated tubular adenocarcinoma(tub1),moderately differentiated tubular adenocarcinoma(tub2),poorly differentiated adenocarcinoma(por)and signet-ring cell carcinoma(sig) were studied.Results In 102 cases of Ⅱc type early gastric cancer,there were tubl 27 cases,tub2 11, por 26 and sig 38 cases histologically.The margin of the depressed lesions of tub1(24 cases)and tub2 (9 cases)cancers were mostly unsharply demarcated or with fine spicular border,while the margin of lesions of por(15 cases)and sig(31 cases)were mostly clearly and sharply demarcated,with statistical significance (P

Erythroderma with complicated etiology is one of the severe skin diseases and has high mortality,of which the incidence was 0.5％-1.5％ in skin diseases.Erythrodermic psoriasis (EP) is the commonest type of erythroderma.In addition,there are drug-induced erythroderma,erythroderma secondary to preexisting dermatoses,malignancy-related erythroderma,and idiopathic erythroderma of unknown etiology.Erythroderma of different etiologies has various clinical manifestations,resulting in relevant curative effects and outcomes.In this article,we retrospectively investigated 205 erythroderma patients about clinical symptoms,auxiliary examination and treatments,and evaluated the efficacy and prognosis.There were 84 cases of EP among 205 patients,10 cases of erythroderma caused by specific drugs,77 cases of erythroderma secondary to preexisting dermatoses (excluding psoriasis),7 cases of erythroderma patients suffering from malignancy and 27 cases with unknown causes.We concluded that the etiology of male patients in different age groups had significant difference.The incidence of EP was the highest among all types.The EP was commonly accompanied with hypoproteinemia,and changed into psoriasis vulgaris after treatment.Drug-induced erythroderma was commonly accompanied with fever,and mostly cured by systematic steroid therapy.For erythroderma secondary to preexisting der matoses,the original dermatoses must be actively treated to achieve a satisfying prognosis.Erythroderma with malignancy or unknown causes had long-term duration,poor response to the treatment,and high potential to relapse.Therefore,clarifying the etiology,providing an appropiate and individual regimen,and regular follow-up are crucial for the successful treatment of erythroderma with unknown causes.

Objective To analyze the clinical effect of pedicle screw fixation in the treatment of multi-segmental lumbar fracture and dislocation under the guidance of visualization technique. Methods A total of 21 patients with multi-segmental lumbar fracture and dislocation were selected from November 2012 to November 2013. Before the screw implantation, the structure of bilateral pedicle was observed through Mimics software and the implantation parameters were measured. The position of pedicle screws by postoperative CT scan, operation time, and the satisfaction of the patients were assessed. The percentages of anterior vertebral height and Cobb′s angle were measured before operation, 2 weeks and 8 months after operation. Results All patients were satisfied with informed consent score and the way of pedicle screw and the selection of plant were more reasonable. With better screw position, shorter operative time and less blood loss and adverse reactions, pedicle screw fixation achieved good effect. Conclusion With high security and considerable clinical value, pedicle screw fixation in the treatment of multi-segmental lumbar fracture and dislocation under the guidance of visualization technique has exact and good effecct.

Angioplasty ; Humans ; Male ; Middle Aged ; Popliteal Artery ; pathology ; surgery ; Vascular Diseases ; surgery ; therapy

Objective To summarize the clinical experience and efficacy of interventional therapy for pediatric congenital heart disease(CHD) with the Amplatzer Duct Occluder Ⅱ (ADO-Ⅱ). Methods A total of 24 patients had received intervention of CHD with the ADO-Ⅱ,including 18 patients of patent ductus arteriosus(PDA),2 patients of ventricular septal defect(VSD) of muscular part,and 4 patients of coronary artery fistula.All patients were screened by transthoracic echocardiogram before the operations.preoperative. Transthoracic echocardiography was performed to determine the device position, residual shunt and procedural complications during and after ADO-Ⅱ implantation.Results 16 patients with PAD had suecessful transcatheter closure without residual shunt and other complications during the follow-up.Minimal residual shunt was found in 2 PDA patients immediately after the occlusion which became undetectable on control echocardiography the day after operation.3 coronary artery fistula patients had suecessful transcatheter closure without residual shunts,and minimal residual shunt was found in 1 patient with coronary artery fistula at 1 month follow up.All the 2 of VSD patients had suecessful transcatheter closure without residual shunts. No complication and no atrioventricular conduction block were found in these 2 patients. Conclusions Transcatheter closure using the ADO-Ⅱ is safe and effective for interventional therapy for pediatric congenital heart disease.

OBJECTIVETo explore the lipid peroxidation and the testicular morphological change induced by decabrominated diphenyl ether (BDE-209) in male BALB/c mice.

METHODSTwenty one male BALB/c mice were randomly divided into three groups: the high exposure group (500 mg/kg BDE-209), the low exposure group (200 mg/kg BDE-20) and control group (normal saline). The mice were exposed by gavage one time a day for 6 weeks, then were sacrificed. Body weight, testis weight, malonyldialdehyde (MDA), total superoxide dismutase (T-SOD) and glutathione (GSH) in testis were examined. The morphological alteration of testis was observed. TUNEL assay was used to detect the apoptosis in testicular cells.

RESULTSBody weight and testis weight in high and low exposure groups were (21.6140 +/- 2.3550) g, (20.8000 +/- 1.7630) g and (0.1859 +/- 0.0349) g, (0.1718 +/- 0.0266) g, respectively, which were significantly lower than those (27.7570 +/- 1.2880) g and (0.2302 +/- 0.0335) g in the control group (P < 0.05); the testis coefficient in high exposure group was (0.8640% +/- 0.1706%), which was significantly higher than that (0.8329 +/- 0.1386%) in the control group (P < 0.05). The GSH level and SOD activities of testis in 2 BDE-209 groups were 0.044 +/- 0.006, 0.039 +/- 0.005 nmol/mg prot, and 0.735 +/- 0.179, 0.907 +/- 0.198 U/mg prot, respectively, which were significantly lower than those (0.052 +/- 0.067) mol/mg and (1.161 +/- 0.188) U/mg in the control group (P < 0.05). The levels of MDA in 2 BDE-209 groups were (2.365 +/- 0.339) and (1.752 +/- 0.366) nmol/mg prot, which were significantly higher than that (1.173 +/- 0.232 nmol/mg prot) in control group (P < 0.05). there were significant differences of SOD and MDA levels between high exposure group and low exposure group (P < 0.05). Histological examination showed that the number of spermatogenic cells and layer were decreased significantly in 2 exposure groups as compared with control group. TUNEL assay showed that apoptosis cells appeared in 2 exposure groups.

CONCLUSIONBDE-209 changed lipid peroxidation in male BALB/c mice testis and caused toxic effects on the testis.

Animals ; Apoptosis ; Halogenated Diphenyl Ethers ; toxicity ; Lipid Peroxidation ; drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Mutagenicity Tests ; Testis ; drug effects ; metabolism ; pathology

ObjectiveTo investigate the arsenic level in saliva and its relationship with arsenic in urine and drinking water in endemic arsenism area in Shanyin county of Shanxi province.MethodsSeventy individuals from four villages in endemic arsenicosis area in Shanyin county Shanxi provence were selected as research subjects.“The National Diagnosis Standard for Endemic Arsenism” (WS/T211-2001 ) was used to identify and categorize the cases of arsenicosis during the survey.Urine,saliva samples from all individuals and water samples from their families were collected.Total arsenic in saliva,urine and drinking water samples were detected by inductively coupled plasma mass spectrometry (ICP-MS) and atomic fluorescence spectrometry-230 (AFS-230).ResnltsThe median of arsenic in drinking water samples was 127.22 μg/L,and 66.67％ (28/42) of samples' arsenic levels exceeded the drinking water standard,37 individuals had varying degrees of skin lesions among the 70 residents.There was a significant difference of the arsenic concentration in saliva and urine of the residents exposed to different levels of arsenic in drinking water (F =28.643,10.226,all P＜ 0.05).Arsenic levels were positively correlated significantly (r =0.674,0.686,all P＜ 0.05) between water and saliva,urinary.Saliva and urinary arsenic levels were highly correlated (r =0.794,P ＜ 0.05).In addition,arsenic in saliva and urine,water arsenic,skin symptoms were closely related, and the levels of arsenic were significantly different statistically between symptomatic group and asymptomatic group (t =- 3.194,- 4.167,- 4.938,all P ＜ 0.01).ConclusionsSalivary arsenic is significantly correlated with water arsenic and also with skin symptoms of patients with arsenic poisoning,which suggests that salivary arsenic is a potential useful biomarker for assessing human exposure to arsenic.

Objective To investigate the level of arsenic in environmental media and food stuffs including vegetables in water-born endemic arsenicosis area for provide a scientific basis for endemic arsenicosis of Shanxi province.Methods Samples of drinking water,soil,and glutinous broom corn,foxtail millet,and potato were collected from local families in water-born endemic arsenicosis area of Shanyin county,Shanxi province.According to“Diagnosis Standard for Endemic Arsenicosis” (WS/T 211-2001 ),totally 309 people from 126 families were choosen for the survey.The content of arsenic in drinking water,glutinous broom corn and foxtail millet was quantitatively determined by inductively coupled plasma mass spectrometry(ICP-MS).The level of arsenic in soil and potato was measured by atomic fluorescence spectrometer(AFS).The water arsenic concentrations were divided into five groups,≤10,＞ 10 - 50,＞ 50 - 100,＞ 100 - 200,and ＞ 200 μ g/L,analysis the relationship between water arsenic exposure and skin lesions.ResultIn this study,126 water samples were collected.Arsenic concentrations in drinking water were 4.04 - 720.00 μg/L,the median value was 87.75 μg/L,and the ratio of arsenic level higher than the Chinese standards for drinking water(50 μg/L) was 63.49％(80/126).The levels of arsenic in food were 0.16 - 4.58 mg/kg,the median value of arsenic in food was 0.66 mg/kg,and 98.73％(78/79) of arsenic exceeded 0.2 mg/kg.Arsenic concentrations in soil and vegetable were 5.34 - 13.74 mg/kg and 0 - 0.30 mg/kg,respectively.Predicted inorganic arsenic intake from food and vegetable was modeled with the equivalent intake from drinking water for a typical Chinese diet.Daily consumption of grain with a total arsenic level of 0.17 mg/kg would be equivalent to a drinking water arsenic level of 10 μg/L.Otherwise,adjusted with gender and age,symptoms of skin lesions correlated positively with water arsenic concentrations in all subjects.The OR values were 3.219,9.001,56.127,and 97.734 for each group,respectively.Rank correlation test using Chi-square test and Spearman correlation test showed that the severity of skin lesions was associated with the increasing of arsenic content in water(x2 =128.747,P ＜ 0.05; r =0.501,P ＜ 0.05).ConclusionsArsenic levels in both drinking water and food are high in water-born endemic arsenicosis area of Shanxi province,and in soil and vegetables are not high.Arsenic in drinking water has been considered as a main risk factor of skin lesions,and dietary intake of arsenic through foodstuff can not be ignored.

OBJECTIVETo explore the clinical value of detecting primary lesions of colorectal carcinoma with (18)F-FDG PET-CT.

METHODSClinical data of 23 cases of colorectal carcinoma collected from April 2007 to June 2008, including PET-CT, endoscopy, operation and pathology, were analyzed retrospectively.

RESULTSOf the 23 colorectal cancer patients, including 15 males and 8 females, 11 received abdominal CT contrast examination, 7 abdominal CT general examination and 5 chest CT examination. The lesions located in caecum in 5 cases, ascending colon 4 cases, transverse colon 2 cases, descending colon 2 cases, sigmoid colon 4 cases, rectum 6 cases. CT images showed local mass, incrassation and nodes in colon. PET images revealed intensely hypermetabolic lesions. The maximum of standard uptake value (SUVmax) was 11.7+/-9.5, and the delay SUVmax was 14.8+/-11.0. The bigger was the mass, the higher was the SUV. The highest SUV was 44.8. Metastatic lesions were found in 15 cases. More cases and more metastatic lesions were found by (18)F-FDG PET-CT.

CONCLUSIONThe primary and metastatic lesions of colorectal carcinoma can be detected sensitively and exactly by (18)F-FDG PET-CT, which is helpful in tumor staging and making the treatment plan.

Aged ; Colorectal Neoplasms ; diagnostic imaging ; pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lymphatic Metastasis ; diagnostic imaging ; Male ; Middle Aged ; Neoplasm Staging ; methods ; Positron-Emission Tomography