Objective To explore the related factors of plasma superoxide dismutase (SOD) levels in elderly patients with coro‐naryheartdisease.Methods 232elderlypatientswithcoronaryheartinthehospitalwereenrolledinthestudy,thepatientswhose plasma SOD≥129 U/mL were included as group A ,plasma SOD levels <129U /mL were divided into group B ,the difference ob‐served two groups were compared for each observation indicators .Results The two groups in age ,CRP ,TXB2 ,6‐Keto‐PGF1a were statistically significant different(P<0 .05) ,while in the gender composition ,ALT ,TG ,HDL ,LDL ,TC ,Cr ,Hcy was no significant difference(P>0 .05);the proportion of patients with stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis in the two groups were statistically significant different(P<0 .05);in the proportion of hypertension ,type 2 diabetes ,cancer was no statistical‐ly significant difference(P>0 .05);Non conditional Logistic regression results shown that the main factors that led to the decrease of SOD in elderly patients with coronary heart disease were age increase ,CRP increase ,TXB2 increase ,6‐Keto‐PGF1a decrease , stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis .Conclusion Old age ,elevated CRP ,elevated TXB2 ,decreased 6‐Keto‐PGF1a ,stroke ,bacterial pneumonia/acute exacerbation of chronic bronchitis are the factors leading to the decrease of plasma SOD in aged patients with coronary heart disease .

Objectives To establish the mouse heart transplantation model and observe the effect of anti-rejection of IL-12 antibody.Methods Twenty-five mice undergoing heterotopic heart graft were divided into 4 groups:isograft one(n=5),simple homograft one(n=6),γ-globulin treated one(n=6)and IL-12 antibody treated one(n=8).Results The survival time of cardiac graft in the groups was as follows:＞ 100 days in isograft group,7.3 days in simple homograft group,7.5 days in r-globulin treated group and 15.4 days in IL-12 antibody treated group.Conclusions A stable mouse heart transplantation modd was established.IL-12 antibody could significantly prolong the survival of mouse cardiac graft and antagonize rejection of organ transplantation.

Small cell lung cancer(SCLC),characterized with rapid growth and early metastasis ,accounts for about 15~20 percent of all kinds of lung cancer .Patients with extensive disease of SCLC should be treated with combined chemotherapy .The standard treatment for extensive SCLC is etoposide combined with platinum , shortly for EP,with no breakthrough progress in the last decades .This paper briefly reviews the combination of iri-notecan/platinum that showed effectiveness and safety in the treatment of extensive SCLC .

The shortage of liver organ donor is the barrier to the development of liver transplantation.In the past recent years,the usefulness of the donation after cardiac death donor has increased significantly.So the donor after cardiac death may be the important way to expand the liver organ donor pool.The high incidence of the biliary complication,primary non function and the arterial thrombosis may the most important effectors on the survival outcome of the recipients accepted liver after cardiac death.Reducing warm ischemia time,extracorporeal membrane oxygenation and ex vivo hypothermic machine perfusion may be the ways to improve the life quality of the liver donor after cardiac death and the survival outcome of the recipients.

Osteoporosis has become a global public health problem, and dietary interventions may potentially be helpful in preventing this disorder.Salt ( sodium chloride) is one of the most important dietary nutrients.High sodium chloride intake may play an important role in bone metabolism.In this paper, we reviewed the effects of high sodium chlo-ride intake on bone mineral density, bone mineral content and bone biochemical markers, and analyzed the possible causes through currently available literature.Although there are a few inconsistencies results, we conclude a long-term high salt intake can reduce bone density or bone mineral content, change many biochemical markers of bone resorption, which may be caused mainly by increasing urinary calcium excretion and a low-grade metabolic acidosis.However, there are still many unclear aspects need further exploration.

Objective To study the relationship between CA125 and endometriosis.Methods We tested the level of CA125 in serum and fluid of ovarian cysts of patients with endometriosis and non-endometriosis,respectively.Results The mean CA125 concentration in the fluid of endometrial cysts of the ovary(ECO) was remarkably higher than that of the serum in ECO group(P0.05).Conclusion The level of CA125 has bearing on the occurrence,development and prognosis of endometriosis,CA125 level is positively correlated with the severity of the disease.Therefore,it is valuable to test serum CA125 level for diagnosing endometriosis.

Although the organ transplantation had a rapid development in the last 50 years due to the immunosuppression application,the side effect of the immunosppression is one factor affecting the recipient' s long term survival.Immune tolerance induction can solve this problem.Some studies had found a few operational tolerance organ recipients in clinical practice.The regulatory T cells and some gene's expression in the peripheral blood can be used as the potential immune tolerance biomarkers in the operational tolerance kidney and liver recipient.The dentritic cells,and the γδTCR + T cells' number differences were also found in the operational tolerance liver recipient,and B lymphocyte number difference was also found in the peripheral blood of the operational tolerance kidney recipient.All these markers may be the potential biomarker of immune tolerance.As the important role of MicroRNA in the immune system,it may also be the potential immune tolerance biomarker of the organ transplantation.

Wistar-to-SD rat pancreas transplantation was performed in 35 SD rat recipients with diabetes-induced.Donor antigen was administered through IV or PV and the antigen treatment was performed before or during the transplantation.Graft vein was drained into IV or PV.The results showed that donor antigen pretreatment via PV combined with graft drainage PV synergistically prolongs the pancreas graft survival,and the effect of simultananeous antigen treat-ment during transplantation is not as satisfactory as that of antigen pretreatment,but may be more practical.

OBJECTIVE: To improve recognization of clinical, imaging and pathological characteristics of basal cell adenoma (BCA) of parotid gland. METHOD: We collected and analyzed the data of the clinical manifestation, imaging features, histological and immunohistochemical characteristics of BCA of parotid gland (n = 9). RESULTS: Among 9 patients, 2 male, 7 female, and the average age was 55.2 (from 34 to 66 years). The clinical manifestation showed the painless mass in the parotid region. Seven cases underwent CT and other 2 cases underwent MRI. Imaging showed all tumors were located in the superficial lobe, roughly spherical and non-lobulated in shape, with well-defined boundary. The maximal diameter was less than 30 mm. Seven cases showed slightly high density shadow of soft tissue on plain CT. Compared with the parotid signal intensity, two cases showed hypointensity on T1WI and high signal on T2WI. All lesions showed obvious enhancement on delayed contrast CT or MRI. Cystic changes occurred in two cases. Gross observation: the tumors were solid in section, grey, medium in nature and clear with the surrounding tissues. Cystic changes occurred in the superficial region of superficial lobe of two cases. The capsule of tumor was well circumscribed in 8 cases and focally involved in another case. Microscopy: The parenchyma of BCA was mainly composed of basaloid cells, with myoepithelial cells palisading at the periphery of the epithelial nests. Basal membrane separated the parenchyma from the stromal, the latter lacking the myxochondroid matrix. Immunohistochemistry: basaloid cells were positive for CKpan, CD117 and CKL, while myoepithelial cells were positive for P63, SMA, and calponin. The Ki-67 lablel ing index of tumour cell was 0-4%. All patients performed superficial lobe parotidectomy and tumor dissection, and they recovered well postoperatively without tumor recurrence or malignancy. CONCLUSION The BCA of parotid gland has distinctive imaging and pathological features with favourable postoperative prognosis.
Adenoma ; pathology ; surgery ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Parotid Neoplasms ; pathology ; surgery

Purpose：Effect of ST2325 on cell cycle in erbB2-overexpressing MDA-MB-453m1 cells and its mechanism was investigated.Methods：Cell cycle distribution was examined using flow cytometry. The protein expression was detected with Western blot analysis.Results：Under concentrations of 0,6.25,12.5,25.0,50.0,100 μmol/L，the percentrages of G0/G1 in MDA-MB-453m1 were 48.62%, 48.83%, 49.59%, 52.18%, 61.0%,83.96%; the percentages of S were 33.34%, 33.16%, 32.78%,30.77%,25.62%,7.08%;the percentages of G2M were 18.04%, 18.01%,17.63%,17.05%,13.38%,8.96%.After MDA-MB-453m1 cells were treated with different concentrations of ST2325 for 24 hours, Western blot assay showed up-regulation of p27 protein expression and decrease of hyperphosphorylated Rb and cyclin D1 protein expression .Activation of MAPK and AKT in MDA-MB-453m1 was markedly inhibited by ST2325.Conclusions：ST2325 induces G1 arrest in erbB2-overexpressing MDA-MB-453m1 cancer cells. G1 arrest is associated with p27 upregulation,decrease of cyclinD1 protein and hyperphosphorylated Rb.