Objective To analyse the effect of repaglinide combined with Zhenqi Jiangtang Capsules on βcell function in elderly patients with type 2 diabetes mellitus.Methods 60 elderly patients were collected from harbour branch of Hainan provincial People's hospital, who were diagnosed with type 2 diabetes mellitus .All patients were randomly divided into experimental group and control group, 30 cases in each group, 2 groups of patients were given control diet, moderate exercise, and other conventional adjuvant therapy.Control group was treated with repaglinide orally on the basis of routine adjuvant treatment, 1 mg/times, three times per day,experimental group were given Zhenqi Jiangtang Capsules based on the treatment in control group,4 grains/times,three times per day.Both groups were treated for 4 weeks, after the end of treatment, blood glucose levels,serum insulin levels,βcell function and serum lipids in all patients were detected.ResuIts After treatment, compared with control group, the levels of blood glucose, HbA1c and AUCg in experimental group were significantly lower ( P<0.05 );the insulin levels 30 min,60 min, 120 min after meal were significantly higher (P<0.05);the HOMA-IR of patients was significantly lower(P<0.05);IRG, AUCi and AUCi/AUCg were significantly higher (P<0.05);the serum TC, TG, LDL levels were significantly lower, serum HDL levels were significantly higher(P<0.05).ConcIusion Repaglinide combined with Zhenqi Jiangtang Capsules can significantly reduce the blood glucose and lipid levels in elderly patients with type 2 diabetes, improve the function of pancreatic beta cells, promote postprandial insulin secretion and improve insulin resistance.

This paper focuses on investigating the spectral changes of EEG in overtrained athletes through self-normal controls and thus establishing a digital quantitative approach to recognize the EEGs of overtrained ones. In addition, the VEPs of those with overtraining were analysed.During a period of 11 months, EEGs of each of 20 athletes were recorded separately at their overtrained and normal states. A control group was formed of 19 normal athletes, each of whom two EEG exams were made too. The EEG was taken at rest, during periodic flash stimulation and after hyperventilation (HV). Paired t test was performed on the power spectra of EEGs and VEPs, and Fisher classifier were established by the differences of spectral features (DSF) between the two EEGs in each of almost all of the 30 cases.The relative powers of the EEGs in the overtrained cases showed a significant increase (P

This article introduced Professor WENG Li-li’s experience in treating acne. She held that the following four principles should be obeyed during the treatment course: determination of treatment based on syndrome differentiation, application of drugs based on essence of disease; stopping using clearing heat and detoxicating when it achieved therapeutic effect; resolving method was the main method for syndrome of intermingled phlegm and blood stasis; weighing the main and secondary of excess and deficiency.

Objective To study the effect of temporary closure of venous pressure clamp on blood coagulation during duct rinsing in heparin free dialysis.Methods One hundred and forty cases of heparin free dialysis were divided into the control group and observation group according to the singular times dialysis and dual time dialysis,the control group (74 cases with singular times heparin free dialysis) and observation group (66 cases with dual times heparin free dialysis).The rinsing operation of the control group was consistent with the routine dialysis process.In the observation group,the venous pressure clamp was closed before the start of rinsing,and then the venous pressure clamp was opened at the end of this process.The times of alarm,blood pump suspension period,incidence rate and degree of blood coagulation were compared between the two groups to assess the degree of comfort and compliance of all patients during the process.Results The differences between the two groups in terms of times of alarm and blood pump suspension period were statistically significant ((5.7±1.8) times vs.0 times,(9.1±4.0) s vs.0s,P=0.001),the incidence rate of blood coagulation,the degree of blood coagulation above degree Ⅱ and the rate of operation completion ahead of time in the two groups were detected ((70.3% (52/74) vs.7.6% (5/66),21.6% (16/74) vs.0,8.1% (6/74) vs.0).The difference of blood coagulation degree between the two groups was statistically significant (Z=-9.185,P=0.000).Patients in the observation group had a higher grade of comfort degree((4.8±1.0) points vs.(4.2±0.63) points,P=0.001).Conclusion In the operation of heparin free dialysis,the temporary closure of venous pressure clamp can reduce the incidence rate of interruption,prolong the service life of the filter,ensures the dialysis time and treatment effect,and improve the patients' degree of comfort.

In the view of physiology,sleep can be described as an important modulatory factor for hormone release,glucose regulation,and cardiovascular function.The circadian rhythms of hormones is mainly associated with sleep,which is largely mediated by neuroendocrine system.Sleep deprivation will disrupt this rhythm,leading to a series of metabolic diseases.We published an article in 《J Clin Endocrinol Metab》 titled Association between sleep duration,daytime nap duration,and osteoporosis varies by sex,menopause,and sleep quality,which suggested that sleep durations of 7-8 h/day,9-10 h/day,and ≥ 10 h/day,as well as longer daytime napping times,tend to present higher risks of having osteoporosis,and this tendency is especially obvious in postmenopausal women reporting good quality sleep.

Various collateral circulations were detected by 2D color Doppler flow imaging(2DCDFI)in the part of 70 patients of liver cirrhosis with portal hypertension,including reopened umbilical veins,dilated focal intrahepatic veins,dilating,hepatofugal centrifugal hepatic blood flow in the portalveins,perisplenic and retroperitoneai varices etc.Red and blue blood flows were detected in the collateral circulations by 2D-CDFI and appeared as continuous venous spectrum with low velocity blood volume could be calculated to evaluat the therapeulic effectiveness of portal-systemic shunt operation.

Adult ; Aged ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Recurrence ; Retinal Detachment ; etiology ; surgery ; Silicone Oils ; therapeutic use

Objective To analyze the characters of occlusal contact in patients with severe tooth wear. Methods The characters of occlusal contact in 20 cases with severe tooth wear and 20 persons with normal occlusion were measured with T-Scan Ⅱ occlusal analysis system. Results The offset degree in quantitative analysis showed that the offset in transversal and offset distance of center of force in the group with severe tooth wear[ ( 10. 5 ± 1.5 )mm, ( 12. 0 ± 1.3 ) mm ] were larger than control group [ (4. 5 ± 0. 8 )mm,(6. 5 ±0. 8)mm]. Occlusion time in severe tooth wear group[ (0.45 ±0.07)s]was shorter than control group(o)(0.78 ±0.06)s]. Lateral disclusion time in severe tooth wear group[ ( 1. 50 ±0. 08)s, ( 1.50 ±0.10) s ] was longer than control group [ ( 0. 93 ± 0. 07 ) s, ( 0.90 ± 0.11 ) s ]. Incidence rate of lateral occlusal interference in severe tooth wear group(70%) was higher than control group( 10%) (P ＜0.05). Offset in vertical of center of force [ ( 4.9 ± 1.0 ) mm ], protrusive disclusion time [( 1.02 ± 0. 09 ) s ], incidence rate of premature contact and protrusive occlusal contact interference( 20% ,30% ) showed no significantly statistical difference between two groups [ (4. 7 ± 0. 6 ) mm, (0. 96 ± 0. 06 ) s, 10% , 10% ] ( P ＞0. 05). Conclusion There were some differences in the characters of occlusal contact in patients with severe tooth wear.

Animals ; Disease Models, Animal ; Female ; Fibrosis ; metabolism ; pathology ; Hydroxyproline ; metabolism ; Lung ; drug effects ; metabolism ; pathology ; Mice ; Thrombospondin 1 ; pharmacology

Objective To investigate the influence factor of the recovery time of oculomotor nerve palsy (ONP) after traumatic carotid-cavernous sinus fistula (TCCF) treated by balloon embolization.Methods The clinical data of 76 patients with ONP after TCCF were retrospectively analyzed.All patients accepted intravascular balloon embolization treatment.Nonparametric test was applied to make single factor analysis of the influence factor of ONP recovery time,and linear regression analysis was applied to make multiple factor analysis.Results Seventy-six patients (100.0％) had a perfect occlusion for orificium fistulae after operation immediately,and 73 patients (96.1％) retained the internal carotid artery.Patients were followed up for 6-70 months,with an average of 34.2 months and no death cases.Seventy patients (92.1％) succeeded for embolization at the first time,and 6 patients (7.9％) relapsed after embolization for 6 weeks.The reasons of relapse was balloon leak,and no patients recurred after twice embolization.Seventy-six patients (100.0％) had recovery from ONP,and recovery time was (42.17 ± 32.39) d.The single factor analysis showed that the courses of diseases,fistula location,eye-tubercle location,degree of ONP,balloon quantity,state of internal carotid artery were the factor affecting the ONP recovery time (P ＜ 0.01 or ＜ 0.05).The linear regression analysis showed that the courses of the disease,fistula location,degree of ONP,balloon quantity were independent factor affecting the ONP recovery time (P ＜ 0.01).Conclusions Intravascular balloon embolization in the treatment of ONP after TCCF is safe and reliable.The courses of diseases,fistula location,degree of ONP and balloon quantity are the influencing factor of the oculomotor nerve functional recovery time,and should be given enough attention.