Objective:To investigate serum level of vascular endothelial growth factor(VEGF)in patients with rheumatoid arthritis(RA).Methods:VEGF ELISA Quantikine kit.The serum RF level was also d etermined using Beckman Array 360.Results:The serum concen tration of VEGF was significantly higher in patients with RA than in healthy co ntrol(P＜0.01).Conclusion:It suggests that VEGF is involved in the pathog enesis of RA and that measurment of serum concentration of VEGF is noninvasive, usful method for monitoring the disease activity of RA.

Arthritis, Juvenile ; classification ; diagnosis ; therapy ; Child ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis

Esophagus ; Foreign Bodies ; Humans ; Male ; Middle Aged

Adult ; Computer-Aided Design ; Humans ; Male ; Malocclusion ; diagnostic imaging ; therapy ; Orthodontic Appliance Design ; Orthodontic Brackets ; Orthodontic Wires ; Radiography, Panoramic

0.05),and the expression of HoxB5 in the model group tapered after the 7th day,but the expression of HoxB5 increased and reached the peak on the 7th day and expressed in a stable level in the control group and were significantly higher than those of model group(Pa

Objective To study the effects of glycogen synthase kinase-3?(GSK-3?)and free radical on neuron apoptosis of hypoxic-ischemic brain damage(HIBD)in newborn rats.Methods Eighty 7-day-old neonatal rats were randomly divided into 2 groups:normal group and hypoxic-ischemic(HI)group.Rats in HI group were subjected to left common carotid artery ligation,exposed to 80 mL/L oxygen and 920 mL/L nitrogen gas in 37 ℃ closed container for 2.5 h.Rats in 2 groups were killed at 6 hours,24 hours,48 hours,72 hours,5 days after hypoxia respectively.The neuron apoptosis was detected by flow cytometry.The activity of GOD-PX and the contents of SOD and MDA were detected by spectrophotometry,the level of GSK-3? was mensurated by Enzyme-linked immumosorbent assay(ELISA).Results The rates of neuronal apoptosis in HI group were significantly higher than those in normal group at 6,24,48 and 72 hours after hypoxia,respectively(Pa

Objective To investigate the characteristics and extent of mononuclear ceils DNA damage in peripheral blood of mice fed with low dose T-2 toxin and Deoxynivalenol(DON) alone or in combination and to explore the long-term toxicity of the toxin at sub-clinical dose. Methods Eighty female Balb/c mice weighing (14.0 ± 1.5)g 3 weeks after birth were divided randomly into control group, T-2 toxin group, DON group and T-2 toxin combined with DON group according to their body weight, 20 in each group. The mice were injected intraperitoneally T-2 toxin(5 μg·kg-1·d-1), DON(20 μg·kg-1·d-1), T-2 toxin(5 μg·kg-1·d-1) combined with:DON (20μg·kg-1·d-1)respectively,control group were treated by isotonic NaCl. In 16 weeks and 21 weeks of exposure, the tail blood of the mice was collected. The comet rate, tail DNA content,tail length and tail extent moment of mouse mononuclear ceils in peripheral blood was observed using single cell gel electrophoresis(SCGE). Results ① In T-2 toxin group,tail DNA content,tail length and tail extent moment were (27.71 ± 15.85)%, (13.67 ± 5.56)μm, 4.26 ± 3.83 at 16 weeks and (28.38 ± 15.57)%, (13.83 ± 5.47)μm, 4.37 ± 3.82 at 21 weeks, all levels of the indexes increased. In the control group, the corresponding values were (11.87 ± 4.61)%, (10.59±6.70)μm, 1.34±0.98 at 16 weeks and (11.31 ± 3.94)%, (10.83 ± 7.05)μm, 1.29±1.01 at 21 weeks, the differences in the two groups were significant (all P < 0.05) ;②In DON group, the comet rate of cells, tail DNA content and tail extent moment of comet ceils were 5.62%, (28.13 ±13.31)%, 3.39 ± 2.35 at 16 weeks and 7.71%, (29.17 ± 15.12)%, 5.70 ± 4.17 at 21 weeks. In the control group, the tailing rate was 4.34% at 16 weeks and 4.38% at 21 weeks, the differences in the two groups were significant (all P < 0.05);③In the group of T-2 toxin combined with DON,the comet rate, tail DNA content, tail length and tail extent moment was 6.21%, (30.14 ± 15.48)%, (16.93± 6.58)μm, 5.54 ± 4.22 at 16 weeks and 8.17%, (30.85 ± 15.76)%, (17,21±6.45)μm, 5.70 ± 4.17 at 21 weeks. Moreover, the levels were significantly higher than that in the control group(all P < 0.05). The tail DNA content and length of comet cell tail significantly increased in the combine group compared with T-2 group or DON group(P < 0.05). Conclusions Low dose T-2 toxin or DON can definitely result in DNA damage of mononuclear cells in peripheral blood of mice. The damage induced by T-2 toxin combined with DON is severer than that caused by T-2 toxin or DON alone.

Objective To investigate the correlation between executive function(EF) and characteristic of symptom in children with Tourette′s syndrome(TS).Methods EF were measured with Wisconsin Card Sorting Test(WCST) in 53 patients with TS,and symptom characteristics were evaluated with Achenbach Child Behavior Checklist(CBCL) and Yale Global Tic Severity Scale(YGTSS).Results Compared with healthy control,TS had poor executive performances significantly in WCST(all P

ObjectiveTo study the effects of aqueous extract of Trigonella foenum-graecum(AET) on the blood glucose in normal and alloxan(ALX)-diabetic mice.MethodsFasting blood glucose and glucose tolerance in normal and ALX-diabetic mice were measured respectively 7 days after AET had been given.ResultsAET had not significantly effected the fasting blood glucose of normal mice, but improved their glucose toleranc. Otherwise, AET reduced fasting blood glouse of diabetic mice induced by ALX significantly.ConclusionAET can be used on treatment of diabetes mellitus.

Carcinoma, Squamous Cell ; pathology ; therapy ; Female ; Humans ; Neoplasm Invasiveness ; Uterine Cervical Neoplasms ; pathology ; therapy