Mebendazole was tested for its efficacy in individual treatment and mass control of Trichuris trichiura infection in Korea. The results were as follows: The efficacy of mebendazole in 430 cases 3 weeks after treatment with mebendazole(100-1,200 mg) was not so satisfactory (15.0-64.0 and 24.6-95.2% in cure and egg reduction rates respectively). But it was observed that the higher the total dose of the drug the better the efficacy. The egg positive rate of the inhabitants in mass control programme by 600 mg mebendazole decreased form 40.0 to 5.6 % during one year, May 1982-May 1983, by repeated blanket mass chemotherapy every 3 months (in conventional regimen), while the decrease was less marked or unrecognizable in 3-month (signle or two divided doses), 6-month, 12-month interval and placebo control groups. From the results, it was concluded that, although mebendazole was not highly effective in individual treatment of T. trichiura infection, it was fairly useful in mass cotrol, by repeated mass chemotherapy every 3 months.
parasitology-helmith-nematoda ; trichuriasis ; Trichuris trichiura ; chemotherapy-mebendazole ; mebendazol

Blepharoptosis ; parasitology ; Cysticercosis ; complications ; Echinococcosis ; complications ; Humans ; Trichuriasis ; complications

The present clinical trial was conducted to determine the efficacy and tolerance of oxantel(CP-14, 445), one of pyrimidine derivative, in the treatment of Trichocephalus trichiurus infection. One hundred eighty two cases who harboured T. trichiurus were treated with oxantel in a single dose of 10 to 25 mg/kg of body weight. For the evaluation, the negative conversion rate and egg reduction rate were calculated before and 22 days after the treatment. The results obtained were as follows: The prevalence rate of T. trichiurus infection in present study was 64.2% by examining 1,536 fecal specimens collected. The overall negative conversion rate was 66.5%, while the highest rate(93.3%) was obtained in the group treated with 20 mg/kg of oxantel (Group III). The lowest rate(56.6%) was observed in Group I (10 mg/kg). The overall egg reduction rate on present study was 90.3%. The highest rate, 100% of egg reduction was also obtained in Group III (20 mg/kg). From the observation of 1,244 expelled worms, it was known that 45.0% of collected worms were expelled on the first of post-treatment day, and male and female worms were about the same in number(1.03 : 1). Average worm burden per capita was 11.1 in this observation. The medication was readily accepted and tolerated by all the treated cases. On the hemograms, urinalysis and liver function tests, no significant differences were noted before and after the drug administration. Side reactions were so mild and transient that none required specific treatment.
parasitology-helminth-nematoda ; Trichocephalus trichiurus ; oxantel ; chemotherapy-trichuriasis ; drug ; hematology ; liver ; urinalysis ; side reaction

Trichuris trichiura, commonly referred to as a whipworm, has a worldwide distribution, particularly among countries with warm, humid climates. In Korea, trichuriasis was a highly prevalent soil-transmitted helminthiasis until the 1970s. However, the nationwide prevalence decreased to 0.02% in 2004 as a result of national control activities and improvement in the socioeconomic status of Koreans. Most infected individuals have no distinct symptoms, if lightly infected. The diagnosis is typically confirmed by detection of T. trichiura eggs on examination of a stool sample; few reports have described detection of the parasite during colonoscopy. Recently, we managed 4 patients with trichuriasis who were diagnosed by detection of the parasite on colonoscopy, and we reviewed the literature on the colonoscopic diagnosis of T. trichiura in Korea. We suggest that colonoscopy might be a useful diagnostic tool, especially when infected by only a few male worms with no eggs in the stool.
Adult ; Aged ; Animals ; Colonoscopy ; Female ; Humans ; Korea ; Male ; Middle Aged ; Trichuriasis/*diagnosis/parasitology ; Trichuris/*cytology

A paleoparasitological study was carried out on 2 lead coffins recovered from the Roman site of Jaunay-Clan (near Poitiers, France). For the first time, this particular type of burial gave positive parasitological results, and eggs of the whipworm Trichuris trichiura were identified in 1 individual. In the present case, thanatomorphose associated with funerary practices may explain the scarcity of the recovered eggs. However, human whipworm has now been observed in 9 individuals dated to the Roman period. The very high frequency of Trichuris sp. eggs in Roman archaeological sites (up to 80%) suggests that fecal peril, hygiene, and waste management were problematic during this period. Finally, due to the fact that very few analyses have been conducted on human bodies dated to the Roman period, more analyses must be performed in the future to provide further information about diseases in the Roman world.
Burial ; Eggs ; France* ; Human Body ; Humans* ; Hygiene ; Ovum ; Roman World ; Trichuriasis* ; Trichuris ; Waste Management

Trichuriasis is an intestinal infection of human beings caused by Trichuris trichiura, more commonly known as whipworm because of its whip-like appearance. It is characterized by the invasion of the colonic mucosa by the adult trichuris. It is prevalent throughout the world, especially in tropical areas. Diagnosis is made typically by the identification of characteristic barrel-shaped eggs in the feces, although adult worms may be seen rarely at sigmoidoscopy or colonoscopy. We report five cases of whipworm infection that was diagnosed on colonoscopic examination.
Adult ; Colon ; Colonoscopy ; Diagnosis* ; Eggs ; Feces ; Humans ; Mucous Membrane ; Ovum ; Sigmoidoscopy ; Trichuriasis ; Trichuris

We present a human infection with the canine whipworm, Trichuris vulpis, in a child suffering from rhinitis with a diagnosis of rhinitis. T. vulpis eggs resemble those of T. trichiura but they can be differentiated based on their morphological features and egg size, using micrometry with an ocular micrometer. T. vulpis eggs measured an average of 90 microm by 44 microm (range 86-99 microm by 38-47 microm). Prevalence of hookworms (28.1%), Toxocara canis (11.8%), and Trichuris vulpis (3.5%) was found in 292 fecal samples of dogs collected at the peri-domicile, which showed that the risk of infection was not only fortuitous. The treatment of canine whipworm infections is similar to that of T. trichiura infection. We recommend differentiation of the 2 species for their epidemiological and prevention implications.
Animals ; Child ; Feces/parasitology ; Female ; Humans ; Trichuriasis/diagnosis/*parasitology ; Trichuris/*isolation & purification/physiology

Animals ; Female ; Male ; Porcupines ; parasitology ; Trichuriasis ; veterinary ; Trichuris ; anatomy & histology ; classification

Animals ; Female ; Male ; Porcupines ; parasitology ; Trichuriasis ; veterinary ; Trichuris ; anatomy & histology ; classification

A rare human case of gastroenteritis and eosinophilic ascites associated with gastric trichuriasis is described. The patient was a 32-yr-old woman who was working in a farm near Pohang, Korea. She complained of abdominal pain, diarrhea, and vomiting. Endoscopic examination found focal linear hyperemia on the mucosa of the stomach antrum, and endoscopic biopsy confirmed eosinophilic inflammation of the mucosa and submucosa of the stomach, terminal ileum, and cecum. The biopsy specimen of the stomach included a female Trichuris trichiura which was covered by many inflammatory cells on its surface. Ascites and intestinal wall thickening was found by CT scan, and Douglas pouch centesis aspirated bloody ascites which included many eosinophils. She was medicated with prednisolone and albendazole and cured. She is the first case of eosinophilic inflammation of the gastrointestinal tract and ascites associated with trichuriasis in the stomach.
Adult ; Animals ; Ascites/parasitology ; Eosinophilia/parasitology ; Female ; Gastroenteritis/*parasitology ; Human ; Stomach/parasitology ; Trichuriasis/*complications ; Trichuris/*isolation & purification